BRX11_ARATH
ID BRX11_ARATH Reviewed; 315 AA.
AC Q9LE16; Q93Z54;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Ribosome biogenesis protein BRX1 homolog 1 {ECO:0000305};
DE Short=AtBRX1-1 {ECO:0000303|PubMed:25605960};
DE AltName: Full=Brix domain-containing protein 2;
GN Name=BRIX1-1 {ECO:0000303|PubMed:25605960};
GN OrderedLocusNames=At3g15460 {ECO:0000312|Araport:AT3G15460};
GN ORFNames=MJK13.12 {ECO:0000312|EMBL:AAF35412.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INDUCTION BY GLUCOSE.
RX PubMed=17098848; DOI=10.1104/pp.106.091355;
RA Masclaux-Daubresse C., Purdy S., Lemaitre T., Pourtau N., Taconnat L.,
RA Renou J.P., Wingler A.;
RT "Genetic variation suggests interaction between cold acclimation and
RT metabolic regulation of leaf senescence.";
RL Plant Physiol. 143:434-446(2007).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=25605960; DOI=10.1261/rna.047563.114;
RA Weis B.L., Palm D., Missbach S., Bohnsack M.T., Schleiff E.;
RT "atBRX1-1 and atBRX1-2 are involved in an alternative rRNA processing
RT pathway in Arabidopsis thaliana.";
RL RNA 21:415-425(2015).
CC -!- FUNCTION: Involved in pre-rRNA processing and required for biogenesis
CC of the large (60S) ribosomal subunit. Required for proper development.
CC {ECO:0000269|PubMed:25605960}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:25605960}.
CC Note=Associates with 60S pre-ribosomes. {ECO:0000269|PubMed:25605960}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, rosette leaves, stems, flowers,
CC siliques and seeds. {ECO:0000269|PubMed:25605960}.
CC -!- INDUCTION: Induced by glucose. {ECO:0000269|PubMed:17098848}.
CC -!- DISRUPTION PHENOTYPE: Delayed growth rate.
CC {ECO:0000269|PubMed:25605960}.
CC -!- SIMILARITY: Belongs to the BRX1 family. {ECO:0000305}.
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DR EMBL; AB022218; BAB02375.1; -; Genomic_DNA.
DR EMBL; AC024081; AAF35412.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75679.1; -; Genomic_DNA.
DR EMBL; AY058120; AAL25537.1; -; mRNA.
DR EMBL; AY143861; AAN28800.1; -; mRNA.
DR EMBL; AY086298; AAM64370.1; -; mRNA.
DR RefSeq; NP_566514.1; NM_112414.3.
DR AlphaFoldDB; Q9LE16; -.
DR SMR; Q9LE16; -.
DR STRING; 3702.AT3G15460.1; -.
DR PaxDb; Q9LE16; -.
DR PRIDE; Q9LE16; -.
DR ProteomicsDB; 240362; -.
DR EnsemblPlants; AT3G15460.1; AT3G15460.1; AT3G15460.
DR GeneID; 820785; -.
DR Gramene; AT3G15460.1; AT3G15460.1; AT3G15460.
DR KEGG; ath:AT3G15460; -.
DR Araport; AT3G15460; -.
DR TAIR; locus:2090131; AT3G15460.
DR eggNOG; KOG2971; Eukaryota.
DR HOGENOM; CLU_048373_2_0_1; -.
DR InParanoid; Q9LE16; -.
DR OMA; GPTVKMH; -.
DR OrthoDB; 973436at2759; -.
DR PhylomeDB; Q9LE16; -.
DR PRO; PR:Q9LE16; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LE16; baseline and differential.
DR GO; GO:0005730; C:nucleolus; IDA:TAIR.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:InterPro.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IMP:TAIR.
DR GO; GO:0006364; P:rRNA processing; IMP:TAIR.
DR InterPro; IPR007109; Brix.
DR InterPro; IPR026532; BRX1.
DR PANTHER; PTHR13634; PTHR13634; 1.
DR Pfam; PF04427; Brix; 1.
DR SMART; SM00879; Brix; 1.
DR PROSITE; PS50833; BRIX; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..315
FT /note="Ribosome biogenesis protein BRX1 homolog 1"
FT /id="PRO_0000438373"
FT DOMAIN 53..256
FT /note="Brix"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 148
FT /note="L -> V (in Ref. 4; AAL25537/AAN28800)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 315 AA; 36350 MW; 2D4327073B9883F2 CRC64;
MGRKRKHSET VTAAPVKDSA PERPQRTLLG WKDKKEDAEN SKPAYASVFR NKEKVLVTCS
RRINFRYRHL MLNMVSLLPH CKKDSKVEAK SSRGATLNEL IELKGSSSCL FFECRKHKDL
YMWMVKSPGG PSVKFLVNAV HTMEELKLTG NHLKGSRPLL TFSSNFENDA HWKLLKEMLT
QIFGIPEGHR KSKPYHDHVF VFSIVDDHIW FRNYQISVPH NESDKIARGD LDKMTLIEVG
PRFCLNPIKI FGGSFGGTTL YENPFYVSPN QIRALEKRNK AGKFAKKIKA KTRRKMHELS
NPLEPDEFTD MWNDE
