BRX12_ARATH
ID BRX12_ARATH Reviewed; 320 AA.
AC Q9C928;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Ribosome biogenesis protein BRX1 homolog 2 {ECO:0000305};
DE Short=AtBRX1-2 {ECO:0000303|PubMed:25605960};
GN Name=BRIX1-2 {ECO:0000303|PubMed:25605960};
GN OrderedLocusNames=At1g52930 {ECO:0000312|Araport:AT1G52930};
GN ORFNames=F14G24.20 {ECO:0000312|EMBL:AAG52272.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=25605960; DOI=10.1261/rna.047563.114;
RA Weis B.L., Palm D., Missbach S., Bohnsack M.T., Schleiff E.;
RT "atBRX1-1 and atBRX1-2 are involved in an alternative rRNA processing
RT pathway in Arabidopsis thaliana.";
RL RNA 21:415-425(2015).
CC -!- FUNCTION: Involved in pre-rRNA processing and required for biogenesis
CC of the large (60S) ribosomal subunit. Required for proper development.
CC {ECO:0000269|PubMed:25605960}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:25605960}.
CC Note=Associates with 60S pre-ribosomes. {ECO:0000269|PubMed:25605960}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, rosette leaves, stems, flowers,
CC siliques and seeds. {ECO:0000269|PubMed:25605960}.
CC -!- DISRUPTION PHENOTYPE: Delayed growth rate.
CC {ECO:0000269|PubMed:25605960}.
CC -!- SIMILARITY: Belongs to the BRX1 family. {ECO:0000305}.
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DR EMBL; AC019018; AAG52272.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32869.1; -; Genomic_DNA.
DR EMBL; AF370290; AAK44105.1; -; mRNA.
DR EMBL; AY063038; AAL34212.1; -; mRNA.
DR PIR; F96570; F96570.
DR RefSeq; NP_564618.1; NM_104171.3.
DR AlphaFoldDB; Q9C928; -.
DR SMR; Q9C928; -.
DR STRING; 3702.AT1G52930.1; -.
DR PaxDb; Q9C928; -.
DR PRIDE; Q9C928; -.
DR ProteomicsDB; 240676; -.
DR EnsemblPlants; AT1G52930.1; AT1G52930.1; AT1G52930.
DR GeneID; 841726; -.
DR Gramene; AT1G52930.1; AT1G52930.1; AT1G52930.
DR KEGG; ath:AT1G52930; -.
DR Araport; AT1G52930; -.
DR TAIR; locus:2011486; AT1G52930.
DR eggNOG; KOG2971; Eukaryota.
DR HOGENOM; CLU_048373_2_0_1; -.
DR InParanoid; Q9C928; -.
DR OMA; NGPPQTT; -.
DR OrthoDB; 973436at2759; -.
DR PhylomeDB; Q9C928; -.
DR PRO; PR:Q9C928; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C928; baseline and differential.
DR GO; GO:0005730; C:nucleolus; IDA:TAIR.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:InterPro.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IMP:TAIR.
DR GO; GO:0006364; P:rRNA processing; IMP:TAIR.
DR InterPro; IPR007109; Brix.
DR InterPro; IPR026532; BRX1.
DR PANTHER; PTHR13634; PTHR13634; 1.
DR Pfam; PF04427; Brix; 1.
DR SMART; SM00879; Brix; 1.
DR PROSITE; PS50833; BRIX; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..320
FT /note="Ribosome biogenesis protein BRX1 homolog 2"
FT /id="PRO_0000438374"
FT DOMAIN 57..260
FT /note="Brix"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 320 AA; 36697 MW; A686F44FCC592B3C CRC64;
MGRKRKHSET EAPAPVKKSD EPAPDRPKRT LLGWKDKSEG EAEKAKALTS SGFKNKEKVL
VTCSRRISFR YRSLMLNIVS LLPHCKKDSK VEAKSSKGAT LNELIELKNS NSCLFFECRK
HKDLYMWMVK SPNGPSVKFL VKAVHAMEEM KLTGNHLKGS RPLLTFSSNF DKDAHWKLLK
EMLTQVFGIP KEHRKSKPYH DHVFVFSIVD EHIWFRNYQI SVPHNESDKI AKGGLDKMTL
IEVGPRFCLN PIKIFAGSFG GPTLYENPLY VSPNQIRALE KRNKAGKFAK KIKAKTRKKM
HELSNPLEPD EFADMWKDDE
