ID   BRX1_BOVIN              Reviewed;         353 AA.
AC   Q3SZZ0;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Ribosome biogenesis protein BRX1 homolog;
DE   AltName: Full=Brix domain-containing protein 2;
GN   Name=BRIX1; Synonyms=BRIX, BXDC2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRX1 family. {ECO:0000305}.
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DR   EMBL; BC102643; AAI02644.1; -; mRNA.
DR   RefSeq; NP_001029701.1; NM_001034529.2.
DR   AlphaFoldDB; Q3SZZ0; -.
DR   SMR; Q3SZZ0; -.
DR   STRING; 9913.ENSBTAP00000025572; -.
DR   PaxDb; Q3SZZ0; -.
DR   PRIDE; Q3SZZ0; -.
DR   Ensembl; ENSBTAT00000086085; ENSBTAP00000056776; ENSBTAG00000019211.
DR   GeneID; 518501; -.
DR   KEGG; bta:518501; -.
DR   CTD; 55299; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019211; -.
DR   VGNC; VGNC:26569; BRIX1.
DR   eggNOG; KOG2971; Eukaryota.
DR   GeneTree; ENSGT00390000014467; -.
DR   HOGENOM; CLU_048373_2_0_1; -.
DR   InParanoid; Q3SZZ0; -.
DR   OMA; GPTVKMH; -.
DR   OrthoDB; 973436at2759; -.
DR   TreeFam; TF105766; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000019211; Expressed in oocyte and 107 other tissues.
DR   ExpressionAtlas; Q3SZZ0; baseline and differential.
DR   GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:InterPro.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   InterPro; IPR007109; Brix.
DR   InterPro; IPR026532; BRX1.
DR   PANTHER; PTHR13634; PTHR13634; 1.
DR   Pfam; PF04427; Brix; 1.
DR   SMART; SM00879; Brix; 1.
DR   PROSITE; PS50833; BRIX; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW   Ribosome biogenesis; Ubl conjugation.
FT   CHAIN           1..353
FT                   /note="Ribosome biogenesis protein BRX1 homolog"
FT                   /id="PRO_0000269723"
FT   DOMAIN          60..249
FT                   /note="Brix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         261
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDN6"
FT   MOD_RES         276
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDN6"
FT   CROSSLNK        160
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDN6"
FT   CROSSLNK        314
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDN6"
FT   CROSSLNK        322
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDN6"
SQ   SEQUENCE   353 AA;  41064 MW;  4FC4B886B9A0756D CRC64;
     MAATKRKRRG GLAVQAKKLK RDAKDGKLPA KANDVSEEAA EEEKDRIPGP VCKGKWKNKE
     RILIFSSRGI NFRTRHLMQD LRMLMPHSKA DTKMDRKDKL FVINEVCEMK NCNKCIYFEA
     KKKQDLYMWL SNSPHGPSAK FLVQNIHTLA ELKMTGNCLK GSRPLLSFDP AFDELPHYAL
     LKELLIQIFS TPRYHPKSQP FVDHVFTFTI LDNRIWFRNF QIIEEDAALV EIGPRFVLNL
     IKIFQGSFGG PTLYENPHYQ SPNMHRRVIR SITAAKYREK QQVKDVQKLR KKEPKTILPH
     DPTADVFVTP AEEKPVEIQW VKPEPKVDLK ARKKRIYKRQ RKMKQKMSSG NAK