THR_DROPS
ID THR_DROPS Reviewed; 1409 AA.
AC Q6V3W0; Q28XE3;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 3.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Protein three rows;
GN Name=thr; ORFNames=GA19126;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:AAQ72553.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14712087;
RA Jaeger H., Herzig B., Herzig A., Sticht H., Lehner C.F., Heidmann S.;
RT "Structure predictions and interaction studies indicate homology of
RT separase N-terminal regulatory domains and Drosophila THR.";
RL Cell Cycle 3:182-188(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Required specifically for chromosome disjunction during all
CC mitoses; maternally provided protein is sufficient until mitosis 14
CC then zygotic protein is required. Involved in formation and/or
CC maintenance of epithelial structures: bud extension during Malpighian
CC tubule development, and foregut and hindgut morphogenesis (By
CC similarity). {ECO:0000250|UniProtKB:P42286}.
CC -!- SUBUNIT: Interacts with pim and Sse. Cleavage of thr contributes to
CC inactivation of Sse (By similarity). {ECO:0000250|UniProtKB:P42286}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AY352649; AAQ72553.1; -; Genomic_DNA.
DR EMBL; CM000071; EAL26373.2; -; Genomic_DNA.
DR AlphaFoldDB; Q6V3W0; -.
DR STRING; 7237.FBpp0307097; -.
DR eggNOG; ENOG502T8T7; Eukaryota.
DR InParanoid; Q6V3W0; -.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007443; P:Malpighian tubule morphogenesis; ISS:UniProtKB.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; ISS:UniProtKB.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; Developmental protein; Mitosis;
KW Reference proteome.
FT CHAIN 1..1409
FT /note="Protein three rows"
FT /id="PRO_0000072527"
FT REGION 1052..1058
FT /note="Separase cleavage-site"
FT /evidence="ECO:0000250|UniProtKB:P42286"
FT REGION 1260..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1297..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1346..1364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1365..1393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 107
FT /note="K -> R (in Ref. 1; AAQ72553)"
FT /evidence="ECO:0000305"
FT CONFLICT 115
FT /note="M -> I (in Ref. 1; AAQ72553)"
FT /evidence="ECO:0000305"
FT CONFLICT 162
FT /note="E -> Q (in Ref. 1; AAQ72553)"
FT /evidence="ECO:0000305"
FT CONFLICT 465
FT /note="S -> C (in Ref. 1; AAQ72553)"
FT /evidence="ECO:0000305"
FT CONFLICT 730
FT /note="T -> Q (in Ref. 1; AAQ72553)"
FT /evidence="ECO:0000305"
FT CONFLICT 762
FT /note="M -> T (in Ref. 1; AAQ72553)"
FT /evidence="ECO:0000305"
FT CONFLICT 878
FT /note="S -> C (in Ref. 1; AAQ72553)"
FT /evidence="ECO:0000305"
FT CONFLICT 1085
FT /note="V -> M (in Ref. 1; AAQ72553)"
FT /evidence="ECO:0000305"
FT CONFLICT 1237
FT /note="I -> T (in Ref. 1; AAQ72553)"
FT /evidence="ECO:0000305"
FT CONFLICT 1328
FT /note="A -> T (in Ref. 1; AAQ72553)"
FT /evidence="ECO:0000305"
FT CONFLICT 1369
FT /note="S -> T (in Ref. 1; AAQ72553)"
FT /evidence="ECO:0000305"
FT CONFLICT 1405
FT /note="P -> R (in Ref. 1; AAQ72553)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1409 AA; 160196 MW; 1ADED9FC129F16B8 CRC64;
MSADIVKQLK GTRSDVKAAA TTIELKFKEF SKGIGINDAS FPLRYELSVL RQLCLALKDN
LHQHADLYCG IAATMLPHVE PYEEKPSLWE AHLTSLRYIH HGLCQEKSLT ECQKMYGLIR
SQPCRLQEEA DYKFYLDIHL THFNGIYLQM QKETLPLAAT DELYYALEAM GVLFDTMHQR
KVAKNAALLV QLNDSLFSKR SKAFLKYLSA LPPESTTKMY DPLLKLLSCS WATPSSELTN
QFTEYLGLVL ALVQIDMFSI EAPLEQQLAL KLLRICRDLY KDVSPQNYSI QLLYYYVKLM
YVREATADFK QTYIDLCKKF VYFFEHKGAT HAKEQWFMDL LVFFQRLQTL LHQSSNKPPL
DIFWQQLEGD DSSEVYTAHF QLLHGCLGLA VNVVRSPLGT SCSNEACKSI RRHCLLYFGM
CALEAYINWQ PTTEQKADKA PYKPLLGILG YTLDVAKSMK CLGPSAMELV KLVRLLALVA
EKVSCPEQMS LVLAFLEPLQ HLRPLIASQD MLSVLRRIYK ASVHCKSSDM ANRLQSTYLA
ALTNPSRLRS QLFAHYHNAN NTEKCVYEWH ESSPMPNPLT PAQTKQLYDV DLLAVLHFLS
APPVPLLQSL LRCRHNDYHL ALLARKMRTD SEVVRQCEEL RSQLHSTALK QPLSRMQQLA
IGHTSISVLL EALEAQKTKF SIKETAENCL EELIVKNNLL ELNIKREHRL VELATSAIAG
FAAFFERADT EPLGCDDTPI DWEALIDDAV AAAMALSTMG YMAQADEAWL LILRIGQMLD
ERFTYLRALT HFLGQDHLNS NQQLQLSEEV DRAQELLDDL WPQLQNGWFF KRQHTIVMLC
LCHMASYYAR QDCLCHAQLL LLQAEELRAQ FDERVGKSDI VQITIQTVRF RLEYLRNKRC
SSLPRRPTPL RQLDTLVDSV RNYCTVSSVD LGALQLLLAD LVRESTECAA NRLTERFAFY
GTMLNLVLQS GMALRTIEVL ISWLWMNLQM EYLDQAQSKL RLLDHLLAIK PLSRTLVEQT
SATYVPAIAA KEDLKANAMS ELTSNMLLMQ LVEPIRKQNQ MDVATIKSLP MHEPIPTSHQ
LQRYVSKQGT PPHLRDSMQL QCIYFIVGCL HARFSFLKRE NDQLDDFYVG AGNWLQEDPV
RTATLGSMLL VHELYHLNYL RFRKKHKEAL SYAEAGLKSV YQTADINYSF NFMVQLKTAR
LELHPVGKAR AKTIRRALAF NTSPEDKRRK GVVEGSIKAK SSARKTPRFK IYTELELRPP
IGCSNSSSSS SKSGNENTPP SDHVDLNACQ AIEISDDDAA SVSASTPAPS QLKRSQSVPA
KATKTRSARV GSQLKVPEII ELDDTMEETP STSTAATVKR YPTTDARSSR ARNRQLEETP
ATTRGRPRRK VPEPAPQQET VSLRPRQRN
