ID   THR_DROVI               Reviewed;        1411 AA.
AC   Q6V3V8;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Protein three rows;
GN   Name=thr;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1] {ECO:0000312|EMBL:AAQ72555.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14712087;
RA   Jaeger H., Herzig B., Herzig A., Sticht H., Lehner C.F., Heidmann S.;
RT   "Structure predictions and interaction studies indicate homology of
RT   separase N-terminal regulatory domains and Drosophila THR.";
RL   Cell Cycle 3:182-188(2004).
CC   -!- FUNCTION: Required specifically for chromosome disjunction during all
CC       mitoses; maternally provided protein is sufficient until mitosis 14
CC       then zygotic protein is required. Involved in formation and/or
CC       maintenance of epithelial structures: bud extension during Malpighian
CC       tubule development, and foregut and hindgut morphogenesis (By
CC       similarity). {ECO:0000250|UniProtKB:P42286}.
CC   -!- SUBUNIT: Interacts with pim and Sse. Cleavage of thr contributes to
CC       inactivation of Sse (By similarity). {ECO:0000250|UniProtKB:P42286}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AY352651; AAQ72555.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6V3V8; -.
DR   STRING; 7244.FBpp0234523; -.
DR   eggNOG; ENOG502T8T7; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007443; P:Malpighian tubule morphogenesis; ISS:UniProtKB.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; ISS:UniProtKB.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Developmental protein; Mitosis.
FT   CHAIN           1..1411
FT                   /note="Protein three rows"
FT                   /id="PRO_0000072528"
FT   REGION          1065..1071
FT                   /note="Separase cleavage-site"
FT                   /evidence="ECO:0000250|UniProtKB:P42286"
FT   REGION          1221..1240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1268..1301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1330..1411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1268..1290
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1330..1348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1378..1401
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1411 AA;  160080 MW;  1F0F7CCCC7E81F48 CRC64;
     MSLGDVKEQL RGSRTEAKNA AKLIQVQFER VRNGGTTSVA LRALKYELNI LRQLCCALQE
     NFHQHADIYC DIAADMLPHV APHLPQPDYW VNHLMSLQYI HHALCREQTI KQCQRFYELI
     NAQSCQMQNK SEYKYYIDIH IRHVYFFGHQ LGKQSAASEA KAQLCQALQA LGKLLENMLQ
     LKAEQNEGYS ELMGELNQLL GKRSIGYLKN LASLPLTAMN RLWKPLFKLI ACNGGTTDQL
     NAQFSEYLSA LLALLQLDDN VWQLQQSEAQ AQTPLSLQLL HSCRELYKNQ TAQNNVLQLL
     YNYLKLLNTQ SADLKRSYID LAKKFVHFFE HKAVSHVQEQ WYLDFLFVLV RVQKHLHQID
     NKVPSLERFW QCLGGQDSAT AYAAHFELLQ CLTSRVMKIG RGSPLAASCS GNDASCPSVL
     KHCVFTLGCC ATVAYSSWQP EAQATLPKAS QLCLASIIHY AIDVAKVTKC LTPNSSELVT
     FAWYLINMAE KVTTATQMYL LEHLLKPLQE LRPLLSPPYA QQLVRRLFKA SAHSSNPELS
     ALLHGAYIVS MSCPARQFQQ LCVFYHTPKN DTEQCLLELC EKSPLCSPLN ATEKRKLYEL
     DMLAVLANKK TPKLLQSLLR HCQTDYQMVL LGRQMRTDKR SAGQQIEELR VRLQRLGRKQ
     QLTRLQQLIL GHATVTKLLE AAETQKIKIH IKEMTEKTLE VLLVKYKLFD LTISSEMPLL
     ELATTAIGAF ESFYEQADAE PLSSDEALID WEALIDDGIA AAMALSTMGY IPQADNAWLL
     LLRICRLLGD RFNYLRALSH FLPRYTQHAL FDLPAEVSHA EQLLDELWPQ LHAAHLLKRH
     HTTVLLCLCN LALYYARLDC VRHAQLLLLH AQRLRLEFEE RAGKCDIIQL TIQTVRFRMC
     YQQRHCRSLA RLPTALQQLD TLTESVRSFT CISSMDNGAL ILLLGDMVRD TTECTANRLS
     ELPNFSNSLL QLLLQSGLVL RAVELLISWL WTNLRMECLD KAHSKLRLIE HFLGMQPLLE
     SRAALEQTSN KGSLTLAPMD AQSKHMTELV GKMLVMQLEQ SGACVEPIRK QQQLTMSSPR
     RELPLPSARP KLQRYVSLDM QQSHPMLRSS VQLQCIYFMA GCLHARLYFL NREHEQLDDF
     YALANAWLQQ NAARGNALGH MLLVLHIYQA NYLRARRRQQ QAIELTETAL KLAGSEQLQQ
     RIDVNYRYNL LLQLRTAQLE LEPPSKPQNP RRALTFNISP EEKLPRPVRK VATASKKPAK
     FAIYTEDVRP ASSTTSSSSS SSSSENASSP ERKSTKSKSP KRLDLNACQL IDIIDLSDDE
     TEAVVQLQPA KSTSALSTRS TRTRAQRQPD TLVAPLRRTA TAPNPLSAEA TPKTIGTRAR
     ARRQNTAEQP TTTTTATPKV DSVSSRRRHR N