ID   BRX1_CAEEL              Reviewed;         352 AA.
AC   P34524;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Ribosome biogenesis protein BRX1 homolog;
DE   AltName: Full=Brix domain-containing protein 2 homolog;
GN   ORFNames=K12H4.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRX1 family. {ECO:0000305}.
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DR   EMBL; FO081380; CCD71195.1; -; Genomic_DNA.
DR   PIR; S44853; S44853.
DR   RefSeq; NP_498756.1; NM_066355.5.
DR   AlphaFoldDB; P34524; -.
DR   SMR; P34524; -.
DR   BioGRID; 41340; 5.
DR   DIP; DIP-27441N; -.
DR   STRING; 6239.K12H4.3; -.
DR   EPD; P34524; -.
DR   PaxDb; P34524; -.
DR   PeptideAtlas; P34524; -.
DR   EnsemblMetazoa; K12H4.3.1; K12H4.3.1; WBGene00019678.
DR   GeneID; 176134; -.
DR   KEGG; cel:CELE_K12H4.3; -.
DR   UCSC; K12H4.3; c. elegans.
DR   CTD; 176134; -.
DR   WormBase; K12H4.3; CE00268; WBGene00019678; -.
DR   eggNOG; KOG2971; Eukaryota.
DR   GeneTree; ENSGT00390000014467; -.
DR   HOGENOM; CLU_048373_3_0_1; -.
DR   InParanoid; P34524; -.
DR   OMA; GPTVKMH; -.
DR   OrthoDB; 919618at2759; -.
DR   PhylomeDB; P34524; -.
DR   PRO; PR:P34524; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00019678; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:InterPro.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   InterPro; IPR007109; Brix.
DR   InterPro; IPR026532; BRX1.
DR   PANTHER; PTHR13634; PTHR13634; 1.
DR   Pfam; PF04427; Brix; 1.
DR   SMART; SM00879; Brix; 1.
DR   PROSITE; PS50833; BRIX; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..352
FT                   /note="Ribosome biogenesis protein BRX1 homolog"
FT                   /id="PRO_0000120264"
FT   DOMAIN          63..253
FT                   /note="Brix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   352 AA;  40234 MW;  0A1E6A5ED6C5628C CRC64;
     MGKFSKIKKV QEEESAHQKM EWEAAGAKDS SSDDSSDESD NDDQPKQATE ETRKRAELWT
     NRERVLVLCS RGADVRTRYL MKDIKDLLPH AKGDSKLDQQ KSLNVLNEIA EMKNCTKVMY
     FESRKRKDTY LWMSNVEKGP SIKFLVHNVH TMKELKMSGN CLRASRPVLS FDDAFDKKPQ
     LKLIKAVLMQ TLGTPHHHPR SQPFVDHVFN FSVGEGDKIW FRNFQIVDES LQLQEVGPRF
     VLEMVRLFAG SFEGAVLYDN PNYVSPNVIR REHRKGQHSY IEKQLAVKAS NIKQAKVTEI
     LAEKTVDLVG KEFDTQNNAA ADSEAAAQIT AQIEKRRVRK KKSQASKYTG SD