ID   BRX1_DICDI              Reviewed;         326 AA.
AC   Q54JN0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Ribosome biogenesis protein BRX1 homolog;
DE   AltName: Full=Brix domain-containing protein 2 homolog;
GN   Name=bxdc2; ORFNames=DDB_G0287937;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRX1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000105; EAL63475.1; -; Genomic_DNA.
DR   RefSeq; XP_636982.1; XM_631890.1.
DR   AlphaFoldDB; Q54JN0; -.
DR   SMR; Q54JN0; -.
DR   STRING; 44689.DDB0238376; -.
DR   PaxDb; Q54JN0; -.
DR   EnsemblProtists; EAL63475; EAL63475; DDB_G0287937.
DR   GeneID; 8626376; -.
DR   KEGG; ddi:DDB_G0287937; -.
DR   dictyBase; DDB_G0287937; bxdc2.
DR   eggNOG; KOG2971; Eukaryota.
DR   HOGENOM; CLU_048373_3_0_1; -.
DR   InParanoid; Q54JN0; -.
DR   OMA; CLWICKN; -.
DR   PhylomeDB; Q54JN0; -.
DR   PRO; PR:Q54JN0; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005730; C:nucleolus; ISS:dictyBase.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0042134; F:rRNA primary transcript binding; ISS:dictyBase.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; ISS:dictyBase.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   InterPro; IPR007109; Brix.
DR   InterPro; IPR026532; BRX1.
DR   PANTHER; PTHR13634; PTHR13634; 1.
DR   Pfam; PF04427; Brix; 1.
DR   SMART; SM00879; Brix; 1.
DR   PROSITE; PS50833; BRIX; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..326
FT                   /note="Ribosome biogenesis protein BRX1 homolog"
FT                   /id="PRO_0000327887"
FT   DOMAIN          75..268
FT                   /note="Brix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..59
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   326 AA;  38054 MW;  E0E9B8B6E0DD4647 CRC64;
     MVKPSKILEK IKKRTEPVAE PVVEEESDEE IIEQEGSEEE EEIVEEESEE EEEEVEEENK
     NIEENKKDQS IYTKKRVLFT STRGIGSKYR HLMADLISLI PHSKKEDKID DRKTLSLINE
     TCEMKSCNYA ILFDVRKGTD CFLWMAKTPL GPTVKFHITN VHTLDELQMT GNCLKGSRPF
     LHFDKSFDSE VHLQLIKELI TQIYSTPKGH VKSKPFFDHV FSFFYQDGRI WFRNYQISDQ
     EFKKDSLLTE IGPRMIMHID KIFSDGFGGS VLYSNPNYVS PNNTRSDHKL SKANKYIKRK
     YQKGKAEERQ KISFIEPSEV DTVFDN