ID   THSA_ARCFU              Reviewed;         545 AA.
AC   O28045;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Thermosome subunit alpha;
DE   AltName: Full=Chaperonin subunit alpha;
DE   AltName: Full=Thermosome subunit 1;
GN   Name=thsA; OrderedLocusNames=AF_2238;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- FUNCTION: Molecular chaperone; binds unfolded polypeptides in vitro,
CC       and has a weak ATPase activity. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a Heterooligomeric complex of two stacked eight-membered
CC       rings. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TCP-1 chaperonin family. {ECO:0000305}.
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DR   EMBL; AE000782; AAB89014.1; -; Genomic_DNA.
DR   EMBL; AF035826; AAB88860.1; -; Genomic_DNA.
DR   PIR; F69529; F69529.
DR   RefSeq; WP_010878948.1; NC_000917.1.
DR   RefSeq; WP_010879727.1; NC_000917.1.
DR   AlphaFoldDB; O28045; -.
DR   SMR; O28045; -.
DR   STRING; 224325.AF_2238; -.
DR   EnsemblBacteria; AAB89014; AAB89014; AF_2238.
DR   GeneID; 24795063; -.
DR   GeneID; 24796000; -.
DR   KEGG; afu:AF_2238; -.
DR   eggNOG; arCOG01257; Archaea.
DR   HOGENOM; CLU_008891_7_3_2; -.
DR   OMA; HRKGNTW; -.
DR   OrthoDB; 11742at2157; -.
DR   PhylomeDB; O28045; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   CDD; cd03343; cpn60; 1.
DR   Gene3D; 1.10.560.10; -; 1.
DR   Gene3D; 3.30.260.10; -; 1.
DR   Gene3D; 3.50.7.10; -; 1.
DR   InterPro; IPR017998; Chaperone_TCP-1.
DR   InterPro; IPR002194; Chaperonin_TCP-1_CS.
DR   InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR   InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR   InterPro; IPR027413; GROEL-like_equatorial_sf.
DR   InterPro; IPR027410; TCP-1-like_intermed_sf.
DR   InterPro; IPR012714; Thermosome_arc.
DR   PANTHER; PTHR11353; PTHR11353; 1.
DR   Pfam; PF00118; Cpn60_TCP1; 1.
DR   PRINTS; PR00304; TCOMPLEXTCP1.
DR   SUPFAM; SSF48592; SSF48592; 1.
DR   SUPFAM; SSF52029; SSF52029; 1.
DR   SUPFAM; SSF54849; SSF54849; 1.
DR   TIGRFAMs; TIGR02339; thermosome_arch; 1.
DR   PROSITE; PS00750; TCP1_1; 1.
DR   PROSITE; PS00751; TCP1_2; 1.
DR   PROSITE; PS00995; TCP1_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..545
FT                   /note="Thermosome subunit alpha"
FT                   /id="PRO_0000128381"
SQ   SEQUENCE   545 AA;  58978 MW;  C774722EE6AA4EE2 CRC64;
     MATLQGTPVL ILKEGTQRTV GRDAQRMNIM AARVIAEAVK STLGPKGMDK MLVDSLGDVV
     ITNDGVTILK EMDVEHPAAK MIIEVAKTQD NEVGDGTTTA VVLAGELLKK AEELLDQDIH
     PTVIARGYRM AANKAVEILE SIAMDIDVED EETLKKIAAT AITGKHSEYA LDHLSSLVVE
     AVKRVAEKVD DRYKVDEDNI KLEKRQGGSV ADTKLVNGIV IDKEVVHPGM PKRVKNAKIA
     VLKAALEVKE TETDAEIRIT DPDQLMKFIE QEEKMLKEMV DRLAEAGANV VFCQKGIDDL
     AQYYLAKAGI LAVRRVKQSD IEKIAKACGA KIITDLREIT SADLGEAELV EERKVGDEKM
     VFIEGCKNPK AVTILIRGGS EHVVDEVERS LQDAIKVVKT ALESGKVVAG GGAPEIEVAL
     KIRDWAPTLG GREQLAAEAF ASALEVIPRA LAENSGLDPI DILVELRKAH EEGKTTYGVD
     VFSGEVACMK ERGVLEPLKV KTQAITSATE VAIMILRIDD VIAAKGLEKE KGPEGESGGE
     EDSEE