ID   THSA_HALSA              Reviewed;         562 AA.
AC   Q9HN70;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Thermosome subunit alpha;
DE   AltName: Full=Chaperonin subunit alpha;
DE   AltName: Full=Thermosome subunit 1;
GN   Name=thsA; Synonyms=cctA; OrderedLocusNames=VNG_2226G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: Molecular chaperone; binds unfolded polypeptides in vitro,
CC       and has a weak ATPase activity. {ECO:0000250}.
CC   -!- SUBUNIT: Forms an oligomeric complex of eight-membered rings.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TCP-1 chaperonin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG20351.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE004437; AAG20351.1; ALT_INIT; Genomic_DNA.
DR   PIR; C84373; C84373.
DR   AlphaFoldDB; Q9HN70; -.
DR   SMR; Q9HN70; -.
DR   STRING; 64091.VNG_2226G; -.
DR   PaxDb; Q9HN70; -.
DR   EnsemblBacteria; AAG20351; AAG20351; VNG_2226G.
DR   KEGG; hal:VNG_2226G; -.
DR   PATRIC; fig|64091.14.peg.1711; -.
DR   HOGENOM; CLU_008891_7_3_2; -.
DR   InParanoid; Q9HN70; -.
DR   PhylomeDB; Q9HN70; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   CDD; cd03343; cpn60; 1.
DR   Gene3D; 1.10.560.10; -; 1.
DR   Gene3D; 3.30.260.10; -; 1.
DR   Gene3D; 3.50.7.10; -; 1.
DR   InterPro; IPR017998; Chaperone_TCP-1.
DR   InterPro; IPR002194; Chaperonin_TCP-1_CS.
DR   InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR   InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR   InterPro; IPR027413; GROEL-like_equatorial_sf.
DR   InterPro; IPR027410; TCP-1-like_intermed_sf.
DR   InterPro; IPR012714; Thermosome_arc.
DR   PANTHER; PTHR11353; PTHR11353; 1.
DR   Pfam; PF00118; Cpn60_TCP1; 1.
DR   PRINTS; PR00304; TCOMPLEXTCP1.
DR   SUPFAM; SSF48592; SSF48592; 1.
DR   SUPFAM; SSF52029; SSF52029; 1.
DR   SUPFAM; SSF54849; SSF54849; 1.
DR   TIGRFAMs; TIGR02339; thermosome_arch; 1.
DR   PROSITE; PS00750; TCP1_1; 1.
DR   PROSITE; PS00751; TCP1_2; 1.
DR   PROSITE; PS00995; TCP1_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..562
FT                   /note="Thermosome subunit alpha"
FT                   /id="PRO_0000128385"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          526..551
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   562 AA;  58669 MW;  90C550EE408FC8A1 CRC64;
     MAQQMGNQPL IVLSEDSQRT SGEDAQSMNI TAGKAVAESV RTTLGPKGMD KMLVDSSGEV
     VVTNDGVTIL KEMDIEHPAA NMIVEVAETQ ETEVGDGTTT SVVVSGELLS EAETLLEQDI
     HATTLAQGYR QAAEKAKELL DDAAIDVSAD DTETLEKIAA TAMTGKGAEN AKGVLSDLVV
     RAVQSVADDN DVDTDNVKVE KVTGGAIENS ELIEGVIVDK ERVSENMPYA VEDANIALVD
     DGLEVQETEI DTEVNVTDPD QLQNFLDQEE EQLKEMVDAL KDAGANVVFA DSGIDDMAQH
     YLAKEGILAV RRAKSDDFTR LSRATGATPV SNVNDIEAAD LGAAGSVAQK DIGGDERIFV
     EDVEEAKSVT LILRGGTEHV VDEVERAIED SLGVVRVTLE DGQVMPGGGA PETELAMQLR
     DFADSVGGRE QLAVEAFADA LEVIPRTLAE NAGHDPIDSL VDLRSQHDGG DTEAGLDAYN
     GDVIDMESEG IVEPLRVKTQ AIESATEAAT MILRIDDVIA AGDLAGGQVG DDDGDDGPAG
     GPGGMGGGMG GMGGMGGMGG AM