ID   THSA_METTH              Reviewed;         542 AA.
AC   O26320;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Thermosome subunit alpha;
DE   AltName: Full=Chaperonin subunit alpha;
DE   AltName: Full=Thermosome subunit 1;
GN   Name=thsA; OrderedLocusNames=MTH_218;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Molecular chaperone; binds unfolded polypeptides in vitro,
CC       and has a weak ATPase activity. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a Heterooligomeric complex of two stacked eight-membered
CC       rings. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TCP-1 chaperonin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB84724.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000666; AAB84724.1; ALT_INIT; Genomic_DNA.
DR   PIR; H69126; H69126.
DR   RefSeq; WP_048060772.1; NC_000916.1.
DR   AlphaFoldDB; O26320; -.
DR   SMR; O26320; -.
DR   STRING; 187420.MTH_218; -.
DR   EnsemblBacteria; AAB84724; AAB84724; MTH_218.
DR   GeneID; 1470179; -.
DR   KEGG; mth:MTH_218; -.
DR   PATRIC; fig|187420.15.peg.187; -.
DR   HOGENOM; CLU_008891_7_3_2; -.
DR   OMA; HRKGNTW; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   CDD; cd03343; cpn60; 1.
DR   Gene3D; 1.10.560.10; -; 1.
DR   Gene3D; 3.30.260.10; -; 1.
DR   Gene3D; 3.50.7.10; -; 1.
DR   InterPro; IPR017998; Chaperone_TCP-1.
DR   InterPro; IPR002194; Chaperonin_TCP-1_CS.
DR   InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR   InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR   InterPro; IPR027413; GROEL-like_equatorial_sf.
DR   InterPro; IPR027410; TCP-1-like_intermed_sf.
DR   InterPro; IPR012714; Thermosome_arc.
DR   PANTHER; PTHR11353; PTHR11353; 1.
DR   Pfam; PF00118; Cpn60_TCP1; 1.
DR   PRINTS; PR00304; TCOMPLEXTCP1.
DR   SUPFAM; SSF48592; SSF48592; 1.
DR   SUPFAM; SSF52029; SSF52029; 1.
DR   SUPFAM; SSF54849; SSF54849; 1.
DR   TIGRFAMs; TIGR02339; thermosome_arch; 1.
DR   PROSITE; PS00750; TCP1_1; 1.
DR   PROSITE; PS00751; TCP1_2; 1.
DR   PROSITE; PS00995; TCP1_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..542
FT                   /note="Thermosome subunit alpha"
FT                   /id="PRO_0000128393"
SQ   SEQUENCE   542 AA;  59263 MW;  F0F9876585DFA9AE CRC64;
     MAQGQQPIFI LPQDTSRYVG REAQRINILA GKVLAETVRT TLGPKGMDKM LVDSLGDIVI
     TNDGVTILRE MDISHPAAKM LVEVAKTQED EVGDGTTTAV IIAGELLKEA EKLIEMGVHP
     TIIALGYRNA ALKAQEILEE ISMEASDRDT LMKVAITAMT GKGSERAKEK LAELVVDAVM
     QVEEDGEIDK DNINIQRIQG ASVNESRIVN GIVIDKSRAD TSMPKRIEKA RIALLKYPIE
     VKDLETDAKI RLTDPSQMQA FIEQEEQMIR DMVEKIKSSG ANVVFCQKGI DDLALHYLSR
     EGIMALKRVK KSDIKRIEKA TGARLVTNID DLTAEDLGEA GVIYEKKIFD EVLTFIEECR
     DPKAISIILR GSTKHVAEEM ERALEDAIGV VASTLEDREV VAGGGAPEVE IARKLREYAD
     TISGREQLAV SAFADALEIV PKTLAENAGL DSIDVLVDLR AAHEESPYMG IDVFDGNIVD
     MKEAGVIEPQ RVKKQAIQSA AEAAEMILRI DDMIAARGFD VSSKDEEDME GMGGMGGMPP
     MM