ID   BRX1_DROME              Reviewed;         359 AA.
AC   Q9VZE6; Q8MSC3;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Ribosome biogenesis protein BRX1 homolog;
DE   AltName: Full=Brix domain-containing protein 2 homolog;
GN   ORFNames=CG11583;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- FUNCTION: Required for biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRX1 family. {ECO:0000305}.
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DR   EMBL; AE014296; AAF47877.3; -; Genomic_DNA.
DR   EMBL; AY118916; AAM50776.1; -; mRNA.
DR   RefSeq; NP_001033989.1; NM_001038900.2.
DR   AlphaFoldDB; Q9VZE6; -.
DR   SMR; Q9VZE6; -.
DR   BioGRID; 77459; 6.
DR   IntAct; Q9VZE6; 3.
DR   STRING; 7227.FBpp0073098; -.
DR   PaxDb; Q9VZE6; -.
DR   PRIDE; Q9VZE6; -.
DR   DNASU; 326206; -.
DR   EnsemblMetazoa; FBtr0073242; FBpp0073098; FBgn0035524.
DR   GeneID; 326206; -.
DR   KEGG; dme:Dmel_CG11583; -.
DR   UCSC; CG11583-RA; d. melanogaster.
DR   FlyBase; FBgn0035524; CG11583.
DR   VEuPathDB; VectorBase:FBgn0035524; -.
DR   eggNOG; KOG2971; Eukaryota.
DR   GeneTree; ENSGT00390000014467; -.
DR   HOGENOM; CLU_048373_0_0_1; -.
DR   InParanoid; Q9VZE6; -.
DR   PhylomeDB; Q9VZE6; -.
DR   BioGRID-ORCS; 326206; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 326206; -.
DR   PRO; PR:Q9VZE6; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0035524; Expressed in egg cell and 50 other tissues.
DR   Genevisible; Q9VZE6; DM.
DR   GO; GO:0005730; C:nucleolus; ISS:FlyBase.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; ISS:FlyBase.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; ISS:FlyBase.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   InterPro; IPR007109; Brix.
DR   InterPro; IPR026532; BRX1.
DR   PANTHER; PTHR13634; PTHR13634; 1.
DR   Pfam; PF04427; Brix; 1.
DR   SMART; SM00879; Brix; 1.
DR   PROSITE; PS50833; BRIX; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..359
FT                   /note="Ribosome biogenesis protein BRX1 homolog"
FT                   /id="PRO_0000120233"
FT   DOMAIN          50..241
FT                   /note="Brix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   359 AA;  41618 MW;  7AB53FB6640A98FC CRC64;
     MGRKFQNKKK KAAPQLEIVP LDENPPLPPQ RSSDDVVPKK ARKEKWVNKQ RVLVFSARGI
     SHRDRHLMKD IKTLMPHHRP ESKMERSKTL SVVNEMCEMK HCNKAMLFEG RRKRDLYMWI
     SNTSGSTGPS AKFLIENIHT MAELKMTGNC LRGSRPLLSF DSKFDELPHL KLLKELFVQT
     YSVPNHHPKS QPFVDHVFTF TYLDKRIWFR NFQILSEDGG LSEVGPRYVM NPVKIFDGSF
     TGKTIWENPD YVSPSKQRQV LKKAAKDKYV NRVEQKVKHE ATRPIRAYDG MDNDELFEDD
     DPVETAKILA AIAKKKKEEA AKQTPKSALT KKIKEKQLQA VKDVIERKKA RTIKRVKKV