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THSB_SACS2
ID   THSB_SACS2              Reviewed;         554 AA.
AC   Q9V2T8;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Thermosome subunit beta;
DE   AltName: Full=Chaperonin subunit beta;
DE   AltName: Full=Thermophilic factor 55 beta;
DE            Short=TF55-beta;
DE   AltName: Full=Thermosome subunit 2;
GN   Name=thsB; OrderedLocusNames=SSO0282;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 103-524.
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=10508614; DOI=10.1016/s0960-9822(99)80457-6;
RA   Archibald J.M., Logsdon J.M. Jr., Doolittle W.F.;
RT   "Recurrent paralogy in the evolution of archaeal chaperonins.";
RL   Curr. Biol. 9:1053-1056(1999).
CC   -!- FUNCTION: Molecular chaperone; binds unfolded polypeptides in vitro,
CC       and has a weak ATPase activity. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a Heterooligomeric complex of two stacked eight-membered
CC       rings. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9V2T8; Q9V2S9: thsA; NbExp=7; IntAct=EBI-16195251, EBI-16195227;
CC       Q9V2T8; Q9V2T8: thsB; NbExp=4; IntAct=EBI-16195251, EBI-16195251;
CC   -!- SIMILARITY: Belongs to the TCP-1 chaperonin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK40620.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE006641; AAK40620.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AF149920; AAF03361.1; -; Genomic_DNA.
DR   PIR; E90170; E90170.
DR   RefSeq; WP_009990564.1; NC_002754.1.
DR   PDB; 4XCD; X-ray; 3.79 A; A/B/C/D/E/F=1-554.
DR   PDB; 4XCG; X-ray; 3.74 A; B=1-554.
DR   PDB; 4XCI; X-ray; 3.00 A; B=1-554.
DR   PDB; 6XHI; EM; 4.19 A; A=1-554.
DR   PDB; 6XHJ; EM; 3.62 A; A=1-554.
DR   PDBsum; 4XCD; -.
DR   PDBsum; 4XCG; -.
DR   PDBsum; 4XCI; -.
DR   PDBsum; 6XHI; -.
DR   PDBsum; 6XHJ; -.
DR   AlphaFoldDB; Q9V2T8; -.
DR   SMR; Q9V2T8; -.
DR   DIP; DIP-61907N; -.
DR   IntAct; Q9V2T8; 1.
DR   STRING; 273057.SSO0282; -.
DR   EnsemblBacteria; AAK40620; AAK40620; SSO0282.
DR   GeneID; 44129253; -.
DR   KEGG; sso:SSO0282; -.
DR   PATRIC; fig|273057.12.peg.276; -.
DR   eggNOG; arCOG01257; Archaea.
DR   HOGENOM; CLU_008891_7_3_2; -.
DR   InParanoid; Q9V2T8; -.
DR   OMA; HPAANMI; -.
DR   PhylomeDB; Q9V2T8; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   CDD; cd03343; cpn60; 1.
DR   Gene3D; 1.10.560.10; -; 1.
DR   Gene3D; 3.30.260.10; -; 1.
DR   Gene3D; 3.50.7.10; -; 1.
DR   InterPro; IPR017998; Chaperone_TCP-1.
DR   InterPro; IPR002194; Chaperonin_TCP-1_CS.
DR   InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR   InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR   InterPro; IPR027413; GROEL-like_equatorial_sf.
DR   InterPro; IPR027410; TCP-1-like_intermed_sf.
DR   InterPro; IPR012714; Thermosome_arc.
DR   PANTHER; PTHR11353; PTHR11353; 1.
DR   Pfam; PF00118; Cpn60_TCP1; 1.
DR   PRINTS; PR00304; TCOMPLEXTCP1.
DR   SUPFAM; SSF48592; SSF48592; 1.
DR   SUPFAM; SSF52029; SSF52029; 1.
DR   SUPFAM; SSF54849; SSF54849; 1.
DR   TIGRFAMs; TIGR02339; thermosome_arch; 1.
DR   PROSITE; PS00750; TCP1_1; 1.
DR   PROSITE; PS00751; TCP1_2; 1.
DR   PROSITE; PS00995; TCP1_3; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Chaperone; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..554
FT                   /note="Thermosome subunit beta"
FT                   /id="PRO_0000128402"
FT   REGION          532..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        537..554
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        298
FT                   /note="I -> M (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   HELIX           29..46
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          55..60
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   TURN            61..63
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          64..68
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           71..77
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   TURN            83..85
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           86..92
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          95..97
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           102..121
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   TURN            122..124
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           127..148
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           157..167
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   TURN            168..170
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           177..191
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          193..195
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          198..200
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           203..205
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          206..211
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          219..227
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          234..236
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           281..289
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           305..313
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          318..320
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           324..334
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          355..361
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          364..370
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          378..383
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           387..410
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          412..415
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   TURN            416..418
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           419..431
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           432..434
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           437..460
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           465..475
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           479..481
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          484..486
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   TURN            488..490
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          492..495
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   TURN            496..500
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   STRAND          502..504
FT                   /evidence="ECO:0007829|PDB:4XCI"
FT   HELIX           505..524
FT                   /evidence="ECO:0007829|PDB:4XCI"
SQ   SEQUENCE   554 AA;  59952 MW;  927BF96B78A59547 CRC64;
     MATATVATTP EGIPVIILKE GSSRTYGKEA LRANIAAVKA IEEALKSTYG PRGMDKMLVD
     SLGDITITND GATILDKMDL QHPTGKLLVQ IAKGQDEETA DGTKTAVILA GELAKKAEDL
     LYKEIHPTII VSGYKKAEEI ALKTIQEIAQ PVTINDTDVL RKVALTSLGS KAVAGAREYL
     ADLVVKAVAQ VAELRGDKWY VDLDNVQIVK KHGGSVNDTQ LVYGIVVDKE VVHPGMPKRI
     ENAKIALLDA SLEVEKPELD AEIRINDPTQ MHKFLEEEEN ILKEKVDKIA ATGANVVICQ
     KGIDEVAQHY LAKKGILAVR RAKKSDLEKL ARATGGRVIS NIDELTSQDL GYAALVEERK
     VGEDKMVFVE GAKNPKSVSI LIRGGLERVV DETERALRDA LGTVADVIRD GRAVAGGGAV
     EIEIAKRLRK YAPQVGGKEQ LAIEAYANAI EGLIMILAEN AGLDPIDKLM QLRSLHENET
     NKWYGLNLFT GNPEDMWKLG VIEPALVKMN AVKAATEAVT LVLRIDDIVA AGKKSGSEPS
     GKKEKDKEEK SSED
 
 
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