ID   BRX1_RAT                Reviewed;         352 AA.
AC   Q4QQT6;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Ribosome biogenesis protein BRX1 homolog;
DE   AltName: Full=Brix domain-containing protein 2;
GN   Name=Brix1; Synonyms=Brix, Bxdc2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRX1 family. {ECO:0000305}.
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DR   EMBL; BC098005; AAH98005.1; -; mRNA.
DR   RefSeq; NP_001025086.1; NM_001029915.1.
DR   AlphaFoldDB; Q4QQT6; -.
DR   SMR; Q4QQT6; -.
DR   STRING; 10116.ENSRNOP00000024285; -.
DR   jPOST; Q4QQT6; -.
DR   PaxDb; Q4QQT6; -.
DR   PRIDE; Q4QQT6; -.
DR   GeneID; 294799; -.
DR   KEGG; rno:294799; -.
DR   CTD; 55299; -.
DR   RGD; 1308508; Brix1.
DR   eggNOG; KOG2971; Eukaryota.
DR   InParanoid; Q4QQT6; -.
DR   OrthoDB; 973436at2759; -.
DR   PhylomeDB; Q4QQT6; -.
DR   PRO; PR:Q4QQT6; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:InterPro.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   InterPro; IPR007109; Brix.
DR   InterPro; IPR026532; BRX1.
DR   PANTHER; PTHR13634; PTHR13634; 1.
DR   Pfam; PF04427; Brix; 1.
DR   SMART; SM00879; Brix; 1.
DR   PROSITE; PS50833; BRIX; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW   Ribosome biogenesis; Ubl conjugation.
FT   CHAIN           1..352
FT                   /note="Ribosome biogenesis protein BRX1 homolog"
FT                   /id="PRO_0000269726"
FT   DOMAIN          59..248
FT                   /note="Brix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..298
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         260
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDN6"
FT   MOD_RES         275
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDN6"
FT   CROSSLNK        159
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDN6"
FT   CROSSLNK        313
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDN6"
FT   CROSSLNK        321
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TDN6"
SQ   SEQUENCE   352 AA;  41115 MW;  F5942D395FC7CCA0 CRC64;
     MAATKRKRRG DLEVQAKKPK KNRKDAGQPA KQADVAKEAE EEKDRIPGPV CKGKWKNKER
     ILIFSSRGIN FRTRHLMQDL RMLMPHSKAD TKMDRKDKLF VINEVCEMKN CNKCIYFEAK
     KKQDLYMWLS NSPHGPSAKF LVQNIHTLAE LKMTGNCLKG SRPLLSFDPA FDDLPHYALL
     KEFLIQIFST PRYHPKSQPF VDHVFTFTIL DNRIWFRNFQ IIEEDAALVE IGPRFVLNLI
     KIFQGSFGGP TLYENPHYQS PNMHRRVVRS ITAAKYREKQ QVKDVQKSRK KEPKTILPHD
     PTADVFVTPA EEKPIEVQWV KPEPKVDLKA RKRRIYKRHR KLQQKMSRGG AK