ID   BRX1_XENLA              Reviewed;         339 AA.
AC   Q8UVY2; Q8AVP3;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Ribosome biogenesis protein BRX1 homolog;
DE   AltName: Full=Brix domain-containing protein 2;
DE   AltName: Full=Bx24;
GN   Name=brix1; Synonyms=brix, bxdc2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11843177; DOI=10.1515/bc.2001.199;
RA   Kaser A., Bogengruber E., Hallegger M., Doppler E., Lepperdinger G.,
RA   Jantsch M., Breitenbach M., Kreil G.;
RT   "Brix from Xenopus laevis and brx1p from yeast define a new family of
RT   proteins involved in the biogenesis of large ribosomal subunits.";
RL   Biol. Chem. 382:1637-1647(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-339.
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for biogenesis of the 60S ribosomal subunit.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the BRX1 family. {ECO:0000305}.
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DR   EMBL; AF319877; AAL37175.1; -; mRNA.
DR   EMBL; BC041554; AAH41554.1; -; mRNA.
DR   AlphaFoldDB; Q8UVY2; -.
DR   SMR; Q8UVY2; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019843; F:rRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   InterPro; IPR007109; Brix.
DR   InterPro; IPR026532; BRX1.
DR   PANTHER; PTHR13634; PTHR13634; 1.
DR   Pfam; PF04427; Brix; 1.
DR   SMART; SM00879; Brix; 1.
DR   PROSITE; PS50833; BRIX; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..339
FT                   /note="Ribosome biogenesis protein BRX1 homolog"
FT                   /id="PRO_0000120232"
FT   DOMAIN          53..242
FT                   /note="Brix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          304..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..339
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        310
FT                   /note="V -> I (in Ref. 2; AAH41554)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        313
FT                   /note="T -> N (in Ref. 2; AAH41554)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   339 AA;  39383 MW;  8BB1782BAE4935A8 CRC64;
     MSAYKRKRGS LPEVATNTKK AKKQLAGSEQ EATAGEEFIV PPPVSEGKWK NKERVLIFSS
     RGINFRTRHL MQDLRSLMPH SRAETKMDRK DKLFVVNEVC EMKNCNKCIY FEAKKKQDLY
     MWLSNSPEGP SAKFLVQNIH TLAELKMSGN CLKGSRPILS FDPAFDREPQ YALLKELLTQ
     IFGTPRYHPR SQPFVDHIFT FSIADNRIWF RNYQIIEEDA ALVEIGPRFV LNLIKIFKGS
     FGGPTLYENP HYQSPNMHRR MIRLATAAKV KEKQQVKEVQ KLKKEEDRPV IPVDPTEAVF
     YTPAEEKPQV IETEPPAPKP KMKRKDKQFK RQRMAKKRM