ID   BRXA_BACCH              Reviewed;         200 AA.
AC   P0DUF0;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   07-APR-2021, sequence version 1.
DT   25-MAY-2022, entry version 5.
DE   RecName: Full=BREX protein BrxA {ECO:0000303|PubMed:25452498};
DE   AltName: Full=NusB-like RNA-binding protein {ECO:0000303|PubMed:25452498};
GN   Name=brxA {ECO:0000303|PubMed:25452498}; ORFNames=BCH308197_0963;
OS   Bacillus cereus (strain H3081.97).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=451708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H3081.97;
RA   Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A.,
RA   Ravel J., Sutton G.;
RT   "Genome sequence of Bacillus cereus H3081.97.";
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION IN ANTIVIRAL DEFENSE, INDUCTION, AND CLASSIFICATION AND
RP   NOMENCLATURE.
RC   STRAIN=H3081.97;
RX   PubMed=25452498; DOI=10.15252/embj.201489455;
RA   Goldfarb T., Sberro H., Weinstock E., Cohen O., Doron S.,
RA   Charpak-Amikam Y., Afik S., Ofir G., Sorek R.;
RT   "BREX is a novel phage resistance system widespread in microbial genomes.";
RL   EMBO J. 34:169-183(2015).
CC   -!- FUNCTION: BREX systems (bacteriophage exclusion) provide immunity
CC       against bacteriophage. Part of a type 1 BREX system. This system allows
CC       phage adsorption but prevents phage DNA replication, without
CC       degradation of the phage DNA. Methylation of bacterial DNA by PglX
CC       probably guides self/non-self discrimination. When the brxA-brxB-brxC-
CC       pglX and pglZ-brxL operons are transformed into a susceptible
CC       B.subtilis strain (BEST7003) they confer resistance to bacteriophages
CC       SPbeta, SP16, Zeta, phi3T and SP02 and partial protection to phages
CC       SP01 and SP82G (these include lytic and temperate phage). They do not
CC       protect against phages phi105, rho10 or rho14. Additionally confers a
CC       very slight reduction in efficiency of plasmid transformation.
CC       {ECO:0000269|PubMed:25452498}.
CC   -!- INDUCTION: Part of the brxA-brxB-brxC-pglX operon.
CC       {ECO:0000269|PubMed:25452498}.
CC   -!- SIMILARITY: Belongs to the BrxA family. {ECO:0000305}.
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DR   EMBL; ABDL02000007; EDZ57423.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0DUF0; -.
DR   SMR; P0DUF0; -.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3540.10; -; 1.
DR   InterPro; IPR014948; BrxA.
DR   InterPro; IPR023137; BrxA_sf.
DR   Pfam; PF08849; DUF1819; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense.
FT   CHAIN           1..200
FT                   /note="BREX protein BrxA"
FT                   /id="PRO_0000452152"
SQ   SEQUENCE   200 AA;  23536 MW;  5F6CF1143B5B18E3 CRC64;
     MVKEQVYKST IKSRPLLFLE MKKVSILLNK GFKEFEVKEK AISENIFQVN TESRKKEIAS
     SVLARLKILD DYLIREIGHG DIESSKAIVL YSIMKTDRLF FEFMNEVFKE KFVFGETFLT
     DADFNIFFEN KQQQSEKVAS WNDYTFYKLK QVYIRILFEA GYLKNQKGNR EIERPLLNID
     VVEHIRALGD GIYMDILVGE