ID   THUM1_BOVIN             Reviewed;         357 AA.
AC   Q24K03;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=THUMP domain-containing protein 1;
GN   Name=THUMPD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a tRNA-binding adapter to mediate NAT10-
CC       dependent tRNA acetylation. {ECO:0000250|UniProtKB:Q9NXG2}.
CC   -!- SUBUNIT: Interacts with NAT10. {ECO:0000250|UniProtKB:Q9NXG2}.
CC   -!- SIMILARITY: Belongs to the THUMPD1 family. {ECO:0000305}.
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DR   EMBL; BC114098; AAI14099.1; -; mRNA.
DR   RefSeq; NP_001039742.1; NM_001046277.1.
DR   AlphaFoldDB; Q24K03; -.
DR   SMR; Q24K03; -.
DR   STRING; 9913.ENSBTAP00000054288; -.
DR   iPTMnet; Q24K03; -.
DR   PaxDb; Q24K03; -.
DR   PRIDE; Q24K03; -.
DR   Ensembl; ENSBTAT00000064153; ENSBTAP00000054288; ENSBTAG00000047673.
DR   GeneID; 524854; -.
DR   KEGG; bta:524854; -.
DR   CTD; 55623; -.
DR   VEuPathDB; HostDB:ENSBTAG00000047673; -.
DR   VGNC; VGNC:35853; THUMPD1.
DR   eggNOG; KOG3943; Eukaryota.
DR   GeneTree; ENSGT00390000002365; -.
DR   HOGENOM; CLU_039352_0_0_1; -.
DR   InParanoid; Q24K03; -.
DR   OMA; ECVFFMK; -.
DR   OrthoDB; 1478461at2759; -.
DR   TreeFam; TF313884; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000047673; Expressed in conceptus and 109 other tissues.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006400; P:tRNA modification; IBA:GO_Central.
DR   CDD; cd11717; THUMP_THUMPD1_like; 1.
DR   InterPro; IPR004114; THUMP_dom.
DR   InterPro; IPR040183; THUMPD1-like.
DR   PANTHER; PTHR13452; PTHR13452; 1.
DR   Pfam; PF02926; THUMP; 1.
DR   SMART; SM00981; THUMP; 1.
DR   PROSITE; PS51165; THUMP; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXG2"
FT   CHAIN           2..357
FT                   /note="THUMP domain-containing protein 1"
FT                   /id="PRO_0000244378"
FT   DOMAIN          147..254
FT                   /note="THUMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00529"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          74..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        302..331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXG2"
FT   MOD_RES         8
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99J36"
FT   MOD_RES         86
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXG2"
FT   MOD_RES         88
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXG2"
FT   MOD_RES         119
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXG2"
FT   MOD_RES         270
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXG2"
SQ   SEQUENCE   357 AA;  39754 MW;  EAE69F76154E897C CRC64;
     MAARIQQSPQ PGGGKRKGKA QYVQAKRARR WDGGGPRQLE PGIQGILITC NMNERKCVEE
     AYSLLNEYGD DMYGPEKFAD KDQQPSGSEG EDDDVEAALK KEVGDIKAST EMRLRRFQSV
     ESGANNVVFI RTLGIEPEKL VHHILQDIYK TKKKKTRVIL RMLPISGTCK AFLEDMKKYA
     ETFLEPWFKA PNKGTFQIVY KSRNNSHMNR EEVIKELAGI VGSLNSENKV DLSNPQYTVV
     VEIIKAVCCL SVVKDYMLFR KYNLQEVVKS AKDLSQLNPK QAAQTGNGKE AKLESGDKSS
     QNDPAEGKNN QQVVPENSEE LGPTESISET HVVNEGVAKP ELASQVTEGS ESNENDL