ID   THYN1_CHICK             Reviewed;         242 AA.
AC   Q90679; Q8QG66;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Thymocyte nuclear protein 1;
DE   AltName: Full=Thymocyte protein Thy28;
DE            Short=cThy28;
GN   Name=THYN1; Synonyms=THY28;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEOLYTIC PROCESSING, PHOSPHORYLATION, AND
RP   TISSUE SPECIFICITY.
RX   PubMed=11445672; DOI=10.1023/a:1011339626128;
RA   Compton M.M., Thomson J.M., Icard A.H.;
RT   "The analysis of cThy28 expression in avian lymphocytes.";
RL   Apoptosis 6:299-314(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Compton M.M., Wickliffe J.K., Waldrip H.W.;
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting
CC       that it acts as a specific reader of 5hmC. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in bursa of fabricus,
CC       thymus and spleen. Also found in the liver, intestine, heart and brain.
CC       {ECO:0000269|PubMed:11445672}.
CC   -!- PTM: Undergoes proteolytic processing during lymphocyte apoptosis.
CC       {ECO:0000269|PubMed:11445672}.
CC   -!- PTM: Phosphorylated. {ECO:0000269|PubMed:11445672}.
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DR   EMBL; U34350; AAA75591.1; -; mRNA.
DR   EMBL; AF499011; AAM18926.1; -; Genomic_DNA.
DR   RefSeq; NP_989618.1; NM_204287.2.
DR   RefSeq; XP_015153423.1; XM_015297937.1.
DR   RefSeq; XP_015153424.1; XM_015297938.1.
DR   AlphaFoldDB; Q90679; -.
DR   SMR; Q90679; -.
DR   STRING; 9031.ENSGALP00000002322; -.
DR   PaxDb; Q90679; -.
DR   GeneID; 374161; -.
DR   KEGG; gga:374161; -.
DR   CTD; 29087; -.
DR   VEuPathDB; HostDB:geneid_374161; -.
DR   eggNOG; KOG3383; Eukaryota.
DR   HOGENOM; CLU_041799_2_0_1; -.
DR   InParanoid; Q90679; -.
DR   OrthoDB; 1522853at2759; -.
DR   PhylomeDB; Q90679; -.
DR   TreeFam; TF332126; -.
DR   PRO; PR:Q90679; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002740; EVE_domain.
DR   InterPro; IPR015947; PUA-like_sf.
DR   Pfam; PF01878; EVE; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..242
FT                   /note="Thymocyte nuclear protein 1"
FT                   /id="PRO_0000262567"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           6..10
FT                   /note="Nuclear localization signal"
FT   COMPBIAS        1..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        51
FT                   /note="L -> W (in Ref. 2; AAM18926)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   242 AA;  27967 MW;  58ED727874F2AED3 CRC64;
     MPWPSRKRDK GAVADKKEPD AKIAKTEEET EDKEEEEKST KPPAGSSKSG LKNWKKAKES
     DSGGEESKIT YCHWLLKSEP ESRLEKGVDV KFSIEDLKAQ PNQTTFWEGV RNYQARNFLR
     AMKLGQQAFF YHSNCKEPGI VGIVKIVKEA YPDHTQFDQK DPHYDSSSRK ENPKWSMVDV
     QFVRMTKRFI PLSEIKTHHL AHKADGGPLK NMMLFSRQRL SIQPLTQEEF DFVLSLEEEK
     PH