THYN1_MOUSE
ID THYN1_MOUSE Reviewed; 226 AA.
AC Q91YJ3;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Thymocyte nuclear protein 1;
DE AltName: Full=Thymocyte protein Thy28;
DE Short=mThy28;
GN Name=Thyn1; Synonyms=Thy28;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12384300; DOI=10.1016/s0378-1119(02)00886-7;
RA Miyaji H., Yoshimoto T., Asakura H., Komachi A., Kamiya S., Takasaki M.,
RA Mizuguchi J.;
RT "Molecular cloning and characterization of the mouse thymocyte protein
RT gene.";
RL Gene 297:189-196(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INDUCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=14601557; DOI=10.1023/a:1025594409056;
RA Jiang X.Z., Toyota H., Yoshimoto T., Takada E., Asakura H., Mizuguchi J.;
RT "Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in
RT Ramos B lymphoma cells.";
RL Apoptosis 8:509-519(2003).
RN [4]
RP INDUCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=14580360; DOI=10.1016/s0040-8166(03)00073-9;
RA Jiang X.Z., Toyota H., Takada E., Yoshimoto T., Kitamura T., Yamada J.,
RA Mizuguchi J.;
RT "Modulation of mThy28 nuclear protein expression during thymocyte
RT development.";
RL Tissue Cell 35:471-478(2003).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP FUNCTION.
RX PubMed=23434322; DOI=10.1016/j.cell.2013.02.004;
RA Spruijt C.G., Gnerlich F., Smits A.H., Pfaffeneder T., Jansen P.W.,
RA Bauer C., Munzel M., Wagner M., Muller M., Khan F., Eberl H.C.,
RA Mensinga A., Brinkman A.B., Lephikov K., Muller U., Walter J., Boelens R.,
RA van Ingen H., Leonhardt H., Carell T., Vermeulen M.;
RT "Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized
RT derivatives.";
RL Cell 152:1146-1159(2013).
CC -!- FUNCTION: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting
CC that it acts as a specific reader of 5hmC.
CC {ECO:0000269|PubMed:23434322}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14580360,
CC ECO:0000269|PubMed:14601557}.
CC -!- TISSUE SPECIFICITY: Expressed in the medulla containing mature
CC thymocytes, but not the cortex having immature thymocytes (at protein
CC level). Abundant expression seen in testis, liver, brain and kidney
CC with lower levels of the expression in thymus, spleen, heart and
CC stomach. {ECO:0000269|PubMed:12384300, ECO:0000269|PubMed:14580360,
CC ECO:0000269|PubMed:14601557}.
CC -!- INDUCTION: Down-regulated upon induction of apoptosis.
CC {ECO:0000269|PubMed:14580360, ECO:0000269|PubMed:14601557}.
CC -!- PTM: Phosphorylated. {ECO:0000250}.
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DR EMBL; AB080370; BAC21100.1; -; mRNA.
DR EMBL; BC016594; AAH16594.1; -; mRNA.
DR CCDS; CCDS22937.1; -.
DR RefSeq; NP_653126.1; NM_144543.2.
DR AlphaFoldDB; Q91YJ3; -.
DR SMR; Q91YJ3; -.
DR STRING; 10090.ENSMUSP00000037614; -.
DR iPTMnet; Q91YJ3; -.
DR PhosphoSitePlus; Q91YJ3; -.
DR EPD; Q91YJ3; -.
DR MaxQB; Q91YJ3; -.
DR PaxDb; Q91YJ3; -.
DR PeptideAtlas; Q91YJ3; -.
DR PRIDE; Q91YJ3; -.
DR ProteomicsDB; 259187; -.
DR Antibodypedia; 33170; 162 antibodies from 25 providers.
DR DNASU; 77862; -.
DR Ensembl; ENSMUST00000039161; ENSMUSP00000037614; ENSMUSG00000035443.
DR Ensembl; ENSMUST00000213683; ENSMUSP00000150823; ENSMUSG00000035443.
DR GeneID; 77862; -.
DR KEGG; mmu:77862; -.
DR UCSC; uc009oqb.2; mouse.
DR CTD; 29087; -.
DR MGI; MGI:1925112; Thyn1.
DR VEuPathDB; HostDB:ENSMUSG00000035443; -.
DR eggNOG; KOG3383; Eukaryota.
DR GeneTree; ENSGT00390000013297; -.
DR HOGENOM; CLU_041799_2_0_1; -.
DR InParanoid; Q91YJ3; -.
DR OMA; DVQFIRM; -.
DR OrthoDB; 1522853at2759; -.
DR PhylomeDB; Q91YJ3; -.
DR TreeFam; TF332126; -.
DR BioGRID-ORCS; 77862; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Thyn1; mouse.
DR PRO; PR:Q91YJ3; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q91YJ3; protein.
DR Bgee; ENSMUSG00000035443; Expressed in floor plate of midbrain and 251 other tissues.
DR ExpressionAtlas; Q91YJ3; baseline and differential.
DR Genevisible; Q91YJ3; MM.
DR GO; GO:0005634; C:nucleus; IDA:HGNC-UCL.
DR InterPro; IPR002740; EVE_domain.
DR InterPro; IPR015947; PUA-like_sf.
DR Pfam; PF01878; EVE; 1.
DR SUPFAM; SSF88697; SSF88697; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..226
FT /note="Thymocyte nuclear protein 1"
FT /id="PRO_0000262565"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 5..10
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 9..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 226 AA; 26178 MW; 57D69619D37CDF89 CRC64;
MPRPRKRQTG TAGPDRKKLS GKRTKTENSE STSVKLENSS LEMTTTFKNG GKNLSNYWLM
KSEPESRLEK GIDMKFSIED LKAQPKQTAC WDGVRNYQAR NFLRAMKLED EAFFYHSNCK
QPGIVGLMKI VKEAYPDHTQ FEKSNPHYDP SSKEDDPKWS MVDVQFVRMM KRFIPLEELK
TYHQAHKATG GPLKSMTLFT RQRLSVQPLT QEEFDFILSL EETEPS
