ID   BRXC_BACCH              Reviewed;        1192 AA.
AC   P0DUF2;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   07-APR-2021, sequence version 1.
DT   25-MAY-2022, entry version 3.
DE   RecName: Full=Probable ATP-binding protein BrxC {ECO:0000303|PubMed:25452498};
DE   AltName: Full=BREX protein BrxC {ECO:0000303|PubMed:25452498};
GN   Name=brxC {ECO:0000303|PubMed:25452498}; Synonyms=BCH308197_0965;
OS   Bacillus cereus (strain H3081.97).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=451708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H3081.97;
RA   Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A.,
RA   Ravel J., Sutton G.;
RT   "Genome sequence of Bacillus cereus H3081.97.";
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION IN ANTIVIRAL DEFENSE, INDUCTION, AND CLASSIFICATION AND
RP   NOMENCLATURE.
RC   STRAIN=H3081.97;
RX   PubMed=25452498; DOI=10.15252/embj.201489455;
RA   Goldfarb T., Sberro H., Weinstock E., Cohen O., Doron S.,
RA   Charpak-Amikam Y., Afik S., Ofir G., Sorek R.;
RT   "BREX is a novel phage resistance system widespread in microbial genomes.";
RL   EMBO J. 34:169-183(2015).
CC   -!- FUNCTION: BREX systems (bacteriophage exclusion) provide immunity
CC       against bacteriophage. A core protein of a type 1 BREX system. This
CC       system allows phage adsorption but prevents phage DNA replication,
CC       without degradation of the phage DNA. Methylation of bacterial DNA by
CC       PglX probably guides self/non-self discrimination. When the brxA-brxB-
CC       brxC-pglX and pglZ-brxL operons are transformed into a susceptible
CC       B.subtilis strain (BEST7003) they confer resistance to bacteriophages
CC       SPbeta, SP16, Zeta, phi3T and SP02 and partial protection to phages
CC       SP01 and SP82G (these include lytic and temperate phage). They do not
CC       protect against phages phi105, rho10 or rho14. Additionally confers a
CC       very slight reduction in efficiency of plasmid transformation.
CC       {ECO:0000269|PubMed:25452498}.
CC   -!- INDUCTION: Part of the brxA-brxB-brxC-pglX operon.
CC       {ECO:0000269|PubMed:25452498}.
CC   -!- SIMILARITY: Belongs to the BrxC family. {ECO:0000305}.
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DR   EMBL; ABDL02000007; EDZ57474.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0DUF2; -.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense.
FT   CHAIN           1..1192
FT                   /note="Probable ATP-binding protein BrxC"
FT                   /id="PRO_0000452157"
SQ   SEQUENCE   1192 AA;  137846 MW;  8D37637B31D3482E CRC64;
     MQIQKMFEKE INRDIKGVIK VGQDDDKNIY QELDEYVVTN ELLHHMGEFF KSYKKGITGH
     TDKMGVWISG FFGSGKSHFL KILSYLLENK HVMDENEINK DAISFFNNKI LDPMVLADMK
     LAGNTTTDVI LFNIDSKSES DSKSDKNAIV KVFNKVFNEM QGFCGSIPWI ADLERQMVKD
     GRYEEFKAEF EKISGNTWEE AREDFYYEED SIIEALSKTT KMSEDAARNW YERAEEDYFI
     SIDRFAKRVR EYVEAKGNNH HVVFLIDELG QYIGNDSQLM LNLQTVVEDI GTQCGGKVWV
     LVTSQQDIDS VVKVNGNDFS KIQGRFDTRL SLSSAHVDEV IKKRILLKNE VGKQTLRLLY
     GDNSSILKNL ITFSGDTAEM KIFNNEEDFV DVYPFIPYQF NLLQKVFTGI RIHGASGKHL
     AEGERSLLSA FQESAMKYAE SETGALIPFS AFYQTIEAFL DSSIRTVIIH AQNNSRLNAY
     DVEVLKLLFL IKYVKELPAN LENLATLMIQ NISDDKIELK KKIESSLIRL SKETLIQKNG
     QEYIFLTNDE QDVNREIKNM HVDSAEVIQK IGDVIFNVVY QDKKYRYSPK YHFSFNTIID
     DRPIGMQTND IGLKIITPYF DATTELNDSE LKMMSMRESN VILKLPQDTS YLDEMTEILR
     IQAYLKIKSG TAASQAIEDI KVRKSREANE RKDRVHIYIT EALKHAQIFV NSQQLDVKEK
     NPVERINDAF KVLIDNLYNK LHYVKKFIDT AKQLNELLVE NTTQLTLSDD NEDANQLAVK
     EVNDYITRLT TRNQQITIKG ITTHFTKQPY GWKDLDIASF IIKLFKGQEI KLQLNSSNLT
     TSERDLVNYI TKRDYVERVV VKKRERISPA LMKVVKDLSK EVFEVTALPD DEDGLMNRFK
     ELLVSEKNKI NVLLVQYRNT FYPGQDVLQD GKESIEQLLN ISDTTSFYNK VKQLQNDFLD
     YAEDVEPVKA FFETQRDIYD DAVKRLNIFE KNQTYVTDQK VTGFIESISK IVKHKEPYKN
     IHQLPGLIKE FDELFVELLE KECEPVKNVI ESDYQTVLEE LNKHEEIKSM FFNKFKNSFD
     GIKDRLNRVN NFYEAIAMQT ESDRLKVRCI DDIANEVERR KPPVTSPCTG TTCTTVIDPI
     VEYKAKKKTI SKNTILRGTK TIENEEDIEA VLDEIRKQLQ KELEDASVIK LV