TI11B_ARATH
ID TI11B_ARATH Reviewed; 269 AA.
AC Q9C9E3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Protein TIFY 11B {ECO:0000303|PubMed:17499004};
DE AltName: Full=Jasmonate ZIM domain-containing protein 6 {ECO:0000303|PubMed:17637675, ECO:0000303|PubMed:19151223};
GN Name=TIFY11B {ECO:0000303|PubMed:17499004};
GN Synonyms=JAZ6 {ECO:0000303|PubMed:17637675, ECO:0000303|PubMed:19151223};
GN OrderedLocusNames=At1g72450 {ECO:0000312|Araport:AT1G72450};
GN ORFNames=T10D10.8 {ECO:0000312|EMBL:AAG52575.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP SUBCELLULAR LOCATION, AND INDUCTION BY JASMONATE.
RX PubMed=17637677; DOI=10.1038/nature05960;
RA Thines B., Katsir L., Melotto M., Niu Y., Mandaokar A., Liu G., Nomura K.,
RA He S.Y., Howe G.A., Browse J.;
RT "JAZ repressor proteins are targets of the SCF(COI1) complex during
RT jasmonate signalling.";
RL Nature 448:661-665(2007).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17637675; DOI=10.1038/nature06006;
RA Chini A., Fonseca S., Fernandez G., Adie B., Chico J.M., Lorenzo O.,
RA Garcia-Casado G., Lopez-Vidriero I., Lozano F.M., Ponce M.R., Micol J.L.,
RA Solano R.;
RT "The JAZ family of repressors is the missing link in jasmonate
RT signalling.";
RL Nature 448:666-671(2007).
RN [7]
RP DOMAIN.
RX PubMed=17675405; DOI=10.1105/tpc.107.050708;
RA Yan Y., Stolz S., Chetelat A., Reymond P., Pagni M., Dubugnon L.,
RA Farmer E.E.;
RT "A downstream mediator in the growth repression limb of the jasmonate
RT pathway.";
RL Plant Cell 19:2470-2483(2007).
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17499004; DOI=10.1016/j.tplants.2007.04.004;
RA Vanholme B., Grunewald W., Bateman A., Kohchi T., Gheysen G.;
RT "The tify family previously known as ZIM.";
RL Trends Plant Sci. 12:239-244(2007).
RN [9]
RP INDUCTION BY WOUNDING AND HERBIVORY.
RX PubMed=18223147; DOI=10.1104/pp.107.115691;
RA Chung H.S., Koo A.J., Gao X., Jayanty S., Thines B., Jones A.D., Howe G.A.;
RT "Regulation and function of Arabidopsis JASMONATE ZIM-domain genes in
RT response to wounding and herbivory.";
RL Plant Physiol. 146:952-964(2008).
RN [10]
RP FUNCTION, INTERACTION WITH TIFY10A/JAZ1; TIFY10B/JAZ2; TIFY11A/JAZ5;
RP TIFY5A/JAZ8; TIFY9/JAZ10 AND TIFY3B/JAZ12, AND SUBUNIT.
RX PubMed=19151223; DOI=10.1105/tpc.108.064097;
RA Chung H.S., Howe G.A.;
RT "A critical role for the TIFY motif in repression of jasmonate signaling by
RT a stabilized splice variant of the JASMONATE ZIM-domain protein JAZ10 in
RT Arabidopsis.";
RL Plant Cell 21:131-145(2009).
RN [11]
RP INTERACTION WITH MYC2.
RX PubMed=19309455; DOI=10.1111/j.1365-313x.2009.03852.x;
RA Chini A., Fonseca S., Chico J.M., Fernandez-Calvo P., Solano R.;
RT "The ZIM domain mediates homo- and heteromeric interactions between
RT Arabidopsis JAZ proteins.";
RL Plant J. 59:77-87(2009).
RN [12]
RP INTERACTION WITH AFPH2/NINJA.
RX PubMed=20360743; DOI=10.1038/nature08854;
RA Pauwels L., Barbero G.F., Geerinck J., Tilleman S., Grunewald W.,
RA Perez A.C., Chico J.M., Bossche R.V., Sewell J., Gil E., Garcia-Casado G.,
RA Witters E., Inze D., Long J.A., De Jaeger G., Solano R., Goossens A.;
RT "NINJA connects the co-repressor TOPLESS to jasmonate signalling.";
RL Nature 464:788-791(2010).
RN [13]
RP INTERACTION WITH PSEUDOMONAS SYRINGAE HOPZ1A (MICROBIAL INFECTION),
RP SUBCELLULAR LOCATION (MICROBIAL INFECTION), DOMAIN, ACETYLATION BY
RP PSEUDOMONAS SYRINGAE HOPZ1A (MICROBIAL INFECTION), AND MUTAGENESIS OF
RP 191-SER--LYS-200.
RC STRAIN=cv. Columbia;
RX PubMed=24204266; DOI=10.1371/journal.ppat.1003715;
RA Jiang S., Yao J., Ma K.-W., Zhou H., Song J., He S.Y., Ma W.;
RT "Bacterial effector activates jasmonate signaling by directly targeting JAZ
RT transcriptional repressors.";
RL PLoS Pathog. 9:e1003715-e1003715(2013).
CC -!- FUNCTION: Repressor of jasmonate responses.
CC {ECO:0000269|PubMed:19151223}.
CC -!- SUBUNIT: Homo- and heterodimer. Interacts with MYC2, AFPH2/NINJA,
CC TIFY10A/JAZ1, TIFY10B/JAZ2, TIFY11A/JAZ5, TIFY5A/JAZ8, TIFY9/JAZ10 and
CC TIFY3B/JAZ12. {ECO:0000269|PubMed:19151223,
CC ECO:0000269|PubMed:19309455, ECO:0000269|PubMed:20360743}.
CC -!- SUBUNIT: (Microbial infection) Interacts with the pathogenic
CC Pseudomonas syringae HopZ1a protein. {ECO:0000269|PubMed:24204266}.
CC -!- INTERACTION:
CC Q9C9E3; Q9SV55: AFPH2; NbExp=9; IntAct=EBI-2312120, EBI-1787005;
CC Q9C9E3; Q9LNJ5: BHLH13; NbExp=5; IntAct=EBI-2312120, EBI-4434261;
CC Q9C9E3; Q39204: MYC2; NbExp=7; IntAct=EBI-2312120, EBI-1792336;
CC Q9C9E3; O49687: MYC4; NbExp=3; IntAct=EBI-2312120, EBI-15406909;
CC Q9C9E3; Q9C9L2: TCP15; NbExp=3; IntAct=EBI-2312120, EBI-4426144;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768,
CC ECO:0000269|PubMed:17637677, ECO:0000269|PubMed:24204266}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768,
CC ECO:0000269|PubMed:24204266}. Cell membrane
CC {ECO:0000269|PubMed:24204266}. Note=(Microbial infection) Interacts
CC with Pseudomonas syringae HopZ1a at the plasma membrane and in the
CC nucleus. {ECO:0000269|PubMed:24204266}.
CC -!- INDUCTION: Up-regulated by jasmonate, wounding and herbivory.
CC {ECO:0000269|PubMed:17637677, ECO:0000269|PubMed:18223147}.
CC -!- INDUCTION: (Microbial infection) Triggered to degradation by the
CC pathogenic Pseudomonas syringae HopZ1a protein in a COI1-dependent
CC manner, thereby activating host jasmonate signaling.
CC {ECO:0000250|UniProtKB:Q9LMA8}.
CC -!- DOMAIN: The jas domain (186-210) is required for interaction with COI1
CC and Pseudomonas syringae HopZ1a. {ECO:0000269|PubMed:24204266}.
CC -!- PTM: (Microbial infection) Acetylated by Pseudomonas syringae HopZ1a.
CC {ECO:0000269|PubMed:24204266}.
CC -!- PTM: Ubiquitinated. Targeted for degradation by the SCF(COI1) E3
CC ubiquitin ligase-proteasome pathway during jasmonate signaling.
CC {ECO:0000250|UniProtKB:Q7XPM8}.
CC -!- SIMILARITY: Belongs to the TIFY/JAZ family. {ECO:0000305}.
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DR EMBL; AC016529; AAG52575.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35326.1; -; Genomic_DNA.
DR EMBL; AY059089; AAL15195.1; -; mRNA.
DR EMBL; AY088035; AAM65581.1; -; mRNA.
DR EMBL; AF370147; AAK43962.1; -; mRNA.
DR PIR; F96748; F96748.
DR RefSeq; NP_565043.1; NM_105904.4.
DR AlphaFoldDB; Q9C9E3; -.
DR BioGRID; 28796; 26.
DR DIP; DIP-53274N; -.
DR ELM; Q9C9E3; -.
DR IntAct; Q9C9E3; 12.
DR STRING; 3702.AT1G72450.1; -.
DR PaxDb; Q9C9E3; -.
DR PRIDE; Q9C9E3; -.
DR EnsemblPlants; AT1G72450.1; AT1G72450.1; AT1G72450.
DR GeneID; 843577; -.
DR Gramene; AT1G72450.1; AT1G72450.1; AT1G72450.
DR KEGG; ath:AT1G72450; -.
DR Araport; AT1G72450; -.
DR TAIR; locus:2193957; AT1G72450.
DR eggNOG; ENOG502S4J6; Eukaryota.
DR HOGENOM; CLU_051749_1_0_1; -.
DR InParanoid; Q9C9E3; -.
DR OMA; NSCKSPD; -.
DR OrthoDB; 1280219at2759; -.
DR PhylomeDB; Q9C9E3; -.
DR PRO; PR:Q9C9E3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C9E3; baseline and differential.
DR Genevisible; Q9C9E3; AT.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0031347; P:regulation of defense response; IBA:GO_Central.
DR GO; GO:2000022; P:regulation of jasmonic acid mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0009753; P:response to jasmonic acid; IEP:TAIR.
DR GO; GO:0009611; P:response to wounding; IEP:TAIR.
DR InterPro; IPR018467; CCT_CS.
DR InterPro; IPR040390; TIFY/JAZ.
DR InterPro; IPR010399; Tify_dom.
DR PANTHER; PTHR33077; PTHR33077; 1.
DR Pfam; PF09425; Jas_motif; 1.
DR Pfam; PF06200; tify; 1.
DR SMART; SM00979; TIFY; 1.
DR PROSITE; PS51320; TIFY; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell membrane; Jasmonic acid signaling pathway; Membrane;
KW Nucleus; Plant defense; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..269
FT /note="Protein TIFY 11B"
FT /id="PRO_0000300655"
FT DOMAIN 100..135
FT /note="Tify"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00650"
FT REGION 160..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 186..210
FT /note="Jas"
FT /evidence="ECO:0000255"
FT MOTIF 187..194
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 248..269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 191..200
FT /note="Missing: Impaired interaction with Pseudomonas
FT syringae HopZ1a associated with the loss of HopZ1a-mediated
FT acetylation and altered HopZ1a-triggered degradation."
FT /evidence="ECO:0000269|PubMed:24204266"
SQ SEQUENCE 269 AA; 29850 MW; E67821C53F6B138F CRC64;
MSTGQAPEKS NFSQRCSLLS RYLKEKGSFG NINMGLARKS DLELAGKFDL KGQQNVIKKV
ETSETRPFKL IQKFSIGEAS TSTEDKAIYI DLSEPAKVAP ESGNSQLTIF FGGKVMVFNE
FPEDKAKEIM EVAKEANHVA VDSKNSQSHM NLDKSNVVIP DLNEPTSSGN NEDQETGQQH
QVVERIARRA SLHRFFAKRK DRAVARAPYQ VNQHGSHLPP KPEMVAPSIK SGQSSQHIAT
PPKPKAHNHM PMEVDKKEGQ SSKNLELKL
