TI173_ARATH
ID TI173_ARATH Reviewed; 133 AA.
AC Q9LYG1; Q6S709; Q8LAB0;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit TIM17-3;
GN Name=TIM17-3; OrderedLocusNames=At5g11690; ORFNames=T22P22.80;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12692332; DOI=10.1104/pp.102.016808;
RA Murcha M.W., Lister R., Ho A.Y., Whelan J.;
RT "Identification, expression, and import of components 17 and 23 of the
RT inner mitochondrial membrane translocase from Arabidopsis.";
RL Plant Physiol. 131:1737-1747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=14730085; DOI=10.1104/pp.103.033910;
RA Lister R., Chew O., Lee M.N., Heazlewood J.L., Clifton R., Parker K.L.,
RA Millar A.H., Whelan J.;
RT "A transcriptomic and proteomic characterization of the Arabidopsis
RT mitochondrial protein import apparatus and its response to mitochondrial
RT dysfunction.";
RL Plant Physiol. 134:777-789(2004).
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=17098851; DOI=10.1104/pp.106.090688;
RA Murcha M.W., Elhafez D., Lister R., Tonti-Filippini J., Baumgartner M.,
RA Philippar K., Carrie C., Mokranjac D., Soll J., Whelan J.;
RT "Characterization of the preprotein and amino acid transporter gene family
RT in Arabidopsis.";
RL Plant Physiol. 143:199-212(2007).
CC -!- FUNCTION: Essential component of the TIM17:23 complex, a complex that
CC mediates the translocation of transit peptide-containing proteins
CC across the mitochondrial inner membrane. Links the inner and outer
CC membranes (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the TIM17:23 complex at least composed of TIM23,
CC TIM17 and TIM50. The complex interacts with the TIM44 component of the
CC PAM complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in cotyledons, roots, flowers and leaves.
CC {ECO:0000269|PubMed:12692332, ECO:0000269|PubMed:14730085}.
CC -!- INDUCTION: Down-regulated after antimycin A or rotenone treatments.
CC {ECO:0000269|PubMed:14730085}.
CC -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR EMBL; AY463971; AAR26372.1; -; mRNA.
DR EMBL; AL163814; CAB87687.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91710.1; -; Genomic_DNA.
DR EMBL; BT002810; AAO22630.1; -; mRNA.
DR EMBL; BT004367; AAO42361.1; -; mRNA.
DR EMBL; AY087940; AAM65488.1; -; mRNA.
DR PIR; T48528; T48528.
DR RefSeq; NP_196730.1; NM_121207.4.
DR AlphaFoldDB; Q9LYG1; -.
DR SMR; Q9LYG1; -.
DR STRING; 3702.AT5G11690.1; -.
DR PaxDb; Q9LYG1; -.
DR PRIDE; Q9LYG1; -.
DR ProteomicsDB; 234421; -.
DR EnsemblPlants; AT5G11690.1; AT5G11690.1; AT5G11690.
DR GeneID; 831041; -.
DR Gramene; AT5G11690.1; AT5G11690.1; AT5G11690.
DR KEGG; ath:AT5G11690; -.
DR Araport; AT5G11690; -.
DR TAIR; locus:2181890; AT5G11690.
DR eggNOG; KOG1652; Eukaryota.
DR HOGENOM; CLU_087811_3_1_1; -.
DR InParanoid; Q9LYG1; -.
DR OMA; FRIVEDC; -.
DR OrthoDB; 1590221at2759; -.
DR PhylomeDB; Q9LYG1; -.
DR PRO; PR:Q9LYG1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LYG1; baseline and differential.
DR Genevisible; Q9LYG1; AT.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..133
FT /note="Mitochondrial import inner membrane translocase
FT subunit TIM17-3"
FT /id="PRO_0000420933"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 18
FT /note="A -> T (in Ref. 5; AAM65488)"
FT /evidence="ECO:0000305"
FT CONFLICT 46
FT /note="A -> T (in Ref. 1; AAR26372)"
FT /evidence="ECO:0000305"
FT CONFLICT 79
FT /note="A -> S (in Ref. 5; AAM65488)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="T -> A (in Ref. 1; AAR26372)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 133 AA; 13853 MW; 5805F2CB1A1E2262 CRC64;
MDTKKKSKEH GLYRIVNAIG YAFGAGAVGG SVYHFVRGAY NSPIGARYVG GTQAASMNAP
RLGGTFAVFG GLLSTFDYAL VRIRKKEDPW NSIVAGAATG GVLSIRKGVV AASTSAVMFG
FFLAVLNPPF GSK
