TI17A_HUMAN
ID TI17A_HUMAN Reviewed; 171 AA.
AC Q99595; B2RDM5; Q9BWF5;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit Tim17-A;
DE AltName: Full=Inner membrane preprotein translocase Tim17a;
GN Name=TIMM17A; Synonyms=MIMT17, TIM17, TIM17A, TIMM17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8893850; DOI=10.1006/jmbi.1996.0522;
RA Boemer U., Rassow J., Zufall N., Pfanner N., Meijer M., Maarse A.C.;
RT "The preprotein translocase of the inner mitochondrial membrane:
RT evolutionary conservation of targeting and assembly of Tim17.";
RL J. Mol. Biol. 262:389-395(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10339406; DOI=10.1006/jmbi.1999.2751;
RA Bauer M.F., Gempel K., Reichert A.S., Rappold G.A., Lichtner P.,
RA Gerbitz K.-D., Neupert W., Brunner M., Hofmann S.;
RT "Genetic and structural characterization of the human mitochondrial inner
RT membrane translocase.";
RL J. Mol. Biol. 289:69-82(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow, Brain, Lung, Testis, and Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP INTERACTION WITH DNAJC15.
RX PubMed=23263864; DOI=10.1093/hmg/dds541;
RA Schusdziarra C., Blamowska M., Azem A., Hell K.;
RT "Methylation-controlled J-protein MCJ acts in the import of proteins into
RT human mitochondria.";
RL Hum. Mol. Genet. 22:1348-1357(2013).
CC -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC mediates the translocation of transit peptide-containing proteins
CC across the mitochondrial inner membrane.
CC -!- SUBUNIT: Component of the TIM23 complex at least composed of TIMM23,
CC TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the
CC TIMM44 component of the PAM complex and with DNAJC15.
CC {ECO:0000269|PubMed:23263864}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR EMBL; X97544; CAA66146.1; -; mRNA.
DR EMBL; AF106622; AAD19596.1; -; mRNA.
DR EMBL; AK315602; BAG37972.1; -; mRNA.
DR EMBL; CH471067; EAW91384.1; -; Genomic_DNA.
DR EMBL; BC000294; AAH00294.2; -; mRNA.
DR EMBL; BC004439; AAH04439.1; -; mRNA.
DR EMBL; BC007106; AAH07106.1; -; mRNA.
DR EMBL; BC009784; AAH09784.1; -; mRNA.
DR EMBL; BC015098; AAH15098.1; -; mRNA.
DR EMBL; BC020833; AAH20833.1; -; mRNA.
DR CCDS; CCDS1417.1; -.
DR RefSeq; NP_006326.1; NM_006335.2.
DR AlphaFoldDB; Q99595; -.
DR BioGRID; 115707; 32.
DR ComplexPortal; CPX-6129; TIM23 mitochondrial inner membrane pre-sequence translocase complex, TIM17A variant.
DR CORUM; Q99595; -.
DR IntAct; Q99595; 6.
DR MINT; Q99595; -.
DR STRING; 9606.ENSP00000356256; -.
DR iPTMnet; Q99595; -.
DR PhosphoSitePlus; Q99595; -.
DR SwissPalm; Q99595; -.
DR BioMuta; TIMM17A; -.
DR DMDM; 3219818; -.
DR EPD; Q99595; -.
DR jPOST; Q99595; -.
DR MassIVE; Q99595; -.
DR MaxQB; Q99595; -.
DR PaxDb; Q99595; -.
DR PeptideAtlas; Q99595; -.
DR PRIDE; Q99595; -.
DR ProteomicsDB; 78350; -.
DR TopDownProteomics; Q99595; -.
DR Antibodypedia; 34520; 166 antibodies from 29 providers.
DR DNASU; 10440; -.
DR Ensembl; ENST00000367287.5; ENSP00000356256.4; ENSG00000134375.11.
DR GeneID; 10440; -.
DR KEGG; hsa:10440; -.
DR MANE-Select; ENST00000367287.5; ENSP00000356256.4; NM_006335.3; NP_006326.1.
DR UCSC; uc001gxc.3; human.
DR CTD; 10440; -.
DR DisGeNET; 10440; -.
DR GeneCards; TIMM17A; -.
DR HGNC; HGNC:17315; TIMM17A.
DR HPA; ENSG00000134375; Low tissue specificity.
DR MIM; 605057; gene.
DR neXtProt; NX_Q99595; -.
DR OpenTargets; ENSG00000134375; -.
DR PharmGKB; PA38228; -.
DR VEuPathDB; HostDB:ENSG00000134375; -.
DR eggNOG; KOG1652; Eukaryota.
DR GeneTree; ENSGT00390000017780; -.
DR HOGENOM; CLU_087811_1_1_1; -.
DR InParanoid; Q99595; -.
DR OMA; PWNAIAS; -.
DR OrthoDB; 1590221at2759; -.
DR PhylomeDB; Q99595; -.
DR TreeFam; TF106195; -.
DR PathwayCommons; Q99595; -.
DR Reactome; R-HSA-1268020; Mitochondrial protein import.
DR SignaLink; Q99595; -.
DR SIGNOR; Q99595; -.
DR BioGRID-ORCS; 10440; 136 hits in 1089 CRISPR screens.
DR ChiTaRS; TIMM17A; human.
DR GeneWiki; TIMM17A; -.
DR GenomeRNAi; 10440; -.
DR Pharos; Q99595; Tbio.
DR PRO; PR:Q99595; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q99595; protein.
DR Bgee; ENSG00000134375; Expressed in Brodmann (1909) area 23 and 211 other tissues.
DR Genevisible; Q99595; HS.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IDA:BHF-UCL.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IDA:BHF-UCL.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IC:ComplexPortal.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0006626; P:protein targeting to mitochondrion; TAS:ProtInc.
DR InterPro; IPR005678; Tim17.
DR TIGRFAMs; TIGR00980; 3a0801so1tim17; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Protein transport; Reference proteome; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..171
FT /note="Mitochondrial import inner membrane translocase
FT subunit Tim17-A"
FT /id="PRO_0000210284"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 144..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 9..78
FT /evidence="ECO:0000250|UniProtKB:P39515"
FT VARIANT 113
FT /note="V -> I (in dbSNP:rs4648)"
FT /id="VAR_052305"
SQ SEQUENCE 171 AA; 18024 MW; AAC3C0875424416A CRC64;
MEEYAREPCP WRIVDDCGGA FTMGTIGGGI FQAIKGFRNS PVGVNHRLRG SLTAIKTRAP
QLGGSFAVWG GLFSMIDCSM VQVRGKEDPW NSITSGALTG AILAARNGPV AMVGSAAMGG
ILLALIEGAG ILLTRFASAQ FPNGPQFAED PSQLPSTQLP SSPFGDYRQY Q
