TI17A_MOUSE
ID TI17A_MOUSE Reviewed; 171 AA.
AC Q9Z0V8;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit Tim17-A;
DE AltName: Full=Inner membrane preprotein translocase Tim17a;
GN Name=Timm17a; Synonyms=Tim17a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10339406; DOI=10.1006/jmbi.1999.2751;
RA Bauer M.F., Gempel K., Reichert A.S., Rappold G.A., Lichtner P.,
RA Gerbitz K.-D., Neupert W., Brunner M., Hofmann S.;
RT "Genetic and structural characterization of the human mitochondrial inner
RT membrane translocase.";
RL J. Mol. Biol. 289:69-82(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC mediates the translocation of transit peptide-containing proteins
CC across the mitochondrial inner membrane.
CC -!- SUBUNIT: Component of the TIM23 complex at least composed of TIMM23,
CC TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the
CC TIMM44 component of the PAM complex. The complex also interacts with
CC DNAJC15 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR EMBL; AF106620; AAD19594.1; -; mRNA.
DR EMBL; BC010830; AAH10830.1; -; mRNA.
DR CCDS; CCDS15318.1; -.
DR RefSeq; NP_035720.1; NM_011590.2.
DR AlphaFoldDB; Q9Z0V8; -.
DR SMR; Q9Z0V8; -.
DR STRING; 10090.ENSMUSP00000079883; -.
DR PhosphoSitePlus; Q9Z0V8; -.
DR EPD; Q9Z0V8; -.
DR jPOST; Q9Z0V8; -.
DR MaxQB; Q9Z0V8; -.
DR PaxDb; Q9Z0V8; -.
DR PRIDE; Q9Z0V8; -.
DR ProteomicsDB; 259387; -.
DR Antibodypedia; 34520; 166 antibodies from 29 providers.
DR DNASU; 21854; -.
DR Ensembl; ENSMUST00000081104; ENSMUSP00000079883; ENSMUSG00000062580.
DR GeneID; 21854; -.
DR KEGG; mmu:21854; -.
DR UCSC; uc007csz.1; mouse.
DR CTD; 10440; -.
DR MGI; MGI:1343131; Timm17a.
DR VEuPathDB; HostDB:ENSMUSG00000062580; -.
DR eggNOG; KOG1652; Eukaryota.
DR GeneTree; ENSGT00390000017780; -.
DR HOGENOM; CLU_087811_1_1_1; -.
DR InParanoid; Q9Z0V8; -.
DR OMA; PWNAIAS; -.
DR OrthoDB; 1590221at2759; -.
DR PhylomeDB; Q9Z0V8; -.
DR TreeFam; TF106195; -.
DR BioGRID-ORCS; 21854; 13 hits in 76 CRISPR screens.
DR ChiTaRS; Timm17a; mouse.
DR PRO; PR:Q9Z0V8; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9Z0V8; protein.
DR Bgee; ENSMUSG00000062580; Expressed in morula and 256 other tissues.
DR ExpressionAtlas; Q9Z0V8; baseline and differential.
DR Genevisible; Q9Z0V8; MM.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISO:MGI.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; ISO:MGI.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0010954; P:positive regulation of protein processing; ISO:MGI.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR InterPro; IPR005678; Tim17.
DR TIGRFAMs; TIGR00980; 3a0801so1tim17; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Protein transport; Reference proteome; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..171
FT /note="Mitochondrial import inner membrane translocase
FT subunit Tim17-A"
FT /id="PRO_0000210285"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 144..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 9..78
FT /evidence="ECO:0000250|UniProtKB:P39515"
SQ SEQUENCE 171 AA; 18112 MW; FBF840E83F62EC9B CRC64;
MEEYAREPCP WRIVDDCGGA FTMGTIGGGI FQAFKGFRNS PVGINHRLRG SLTAIKTRAP
QLGGSFAVWG GLFSTIDCSM VQIRGKEDPW NSITSGALTG AILAARNGPV AMVGSAAMGG
ILLALIEGAG ILLTRFASAQ FPNGPQFTED HSQLPSSQLP SSPFGDYRQY Q
