TI17A_RAT
ID TI17A_RAT Reviewed; 171 AA.
AC O35092;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit Tim17-A;
DE AltName: Full=Inner membrane preprotein translocase Tim17a;
GN Name=Timm17a; Synonyms=Mimt17, Tim17, Tim17a, Timm17;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=9538267; DOI=10.1093/oxfordjournals.jbchem.a021997;
RA Ishihara N., Mihara K.;
RT "Identification of the protein import components of the rat mitochondrial
RT inner membrane, rTIM17, rTIM23, and rTIM44.";
RL J. Biochem. 123:722-732(1998).
CC -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC mediates the translocation of transit peptide-containing proteins
CC across the mitochondrial inner membrane.
CC -!- SUBUNIT: Component of the TIM23 complex at least composed of TIMM23,
CC some TIM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with
CC the TIMM44 component of the PAM complex. The complex also interacts
CC with DNAJC15 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR EMBL; AB006450; BAA21818.1; -; mRNA.
DR PIR; JE0153; JE0153.
DR RefSeq; NP_062224.1; NM_019351.1.
DR AlphaFoldDB; O35092; -.
DR CORUM; O35092; -.
DR STRING; 10116.ENSRNOP00000009398; -.
DR jPOST; O35092; -.
DR PaxDb; O35092; -.
DR GeneID; 54311; -.
DR KEGG; rno:54311; -.
DR UCSC; RGD:3862; rat.
DR CTD; 10440; -.
DR RGD; 3862; Timm17a.
DR VEuPathDB; HostDB:ENSRNOG00000007040; -.
DR eggNOG; KOG1652; Eukaryota.
DR HOGENOM; CLU_087811_1_1_1; -.
DR InParanoid; O35092; -.
DR OMA; PWNAIAS; -.
DR OrthoDB; 1590221at2759; -.
DR PhylomeDB; O35092; -.
DR TreeFam; TF106195; -.
DR PRO; PR:O35092; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000007040; Expressed in heart and 20 other tissues.
DR Genevisible; O35092; RN.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISO:RGD.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:RGD.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; ISO:RGD.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0010954; P:positive regulation of protein processing; IMP:RGD.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR InterPro; IPR005678; Tim17.
DR TIGRFAMs; TIGR00980; 3a0801so1tim17; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Protein transport; Reference proteome; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..171
FT /note="Mitochondrial import inner membrane translocase
FT subunit Tim17-A"
FT /id="PRO_0000210286"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 147..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 9..78
FT /evidence="ECO:0000250|UniProtKB:P39515"
SQ SEQUENCE 171 AA; 18038 MW; 4873D1282A2469CC CRC64;
MEEYAREPCP WRIVDDCGGA FTMGTIGGGI FQAFKGFRNS PVGVNHRLRG SLTAIKTRAP
QLGGSFAVWG GLFSTIDCGM VQIRGKEDPW NSITSGALTG AILAARNGPV AMVGSAAMGG
ILLALIEGAG ILLTRFASAQ FPNGPQFAED HSQLPSSQLP SSPFGDYRQY Q
