ID   TI17B_BOVIN             Reviewed;         172 AA.
AC   Q2HJE9;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit Tim17-B;
GN   Name=TIMM17B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC       mediates the translocation of transit peptide-containing proteins
CC       across the mitochondrial inner membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the TIM23 complex at least composed of TIMM23,
CC       TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the
CC       TIMM44 component of the PAM complex and with DNAJC15 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR   EMBL; BC105501; AAI05502.1; -; mRNA.
DR   RefSeq; NP_001039953.1; NM_001046488.2.
DR   AlphaFoldDB; Q2HJE9; -.
DR   SMR; Q2HJE9; -.
DR   STRING; 9913.ENSBTAP00000024618; -.
DR   PaxDb; Q2HJE9; -.
DR   PRIDE; Q2HJE9; -.
DR   GeneID; 540765; -.
DR   KEGG; bta:540765; -.
DR   CTD; 10245; -.
DR   eggNOG; KOG1652; Eukaryota.
DR   InParanoid; Q2HJE9; -.
DR   OrthoDB; 1590221at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IEA:InterPro.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IEA:InterPro.
DR   InterPro; IPR005678; Tim17.
DR   TIGRFAMs; TIGR00980; 3a0801so1tim17; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Protein transport; Reference proteome; Translocation; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..172
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit Tim17-B"
FT                   /id="PRO_0000285496"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          147..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        9..78
FT                   /evidence="ECO:0000250|UniProtKB:P39515"
SQ   SEQUENCE   172 AA;  18321 MW;  4EF0A42B313453DF CRC64;
     MEEYAREPCP WRIVDDCGGA FTMGVIGGGV FQAIKGFRNA PVGMRHRLRG SVNAVRIRAP
     QIGGSFAVWG GLFSTIDCGL VRLRGKEDPW NSITSGALTG AVLAARSVPL AMVGSAMMGG
     ILLALIEGVG ILLTRYTAQQ FRNAPPFLED PGQLPSKEGT PGPGYPSYQQ YH