ID   TI17B_MOUSE             Reviewed;         172 AA.
AC   Q9Z0V7;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit Tim17-B;
GN   Name=Timm17b; Synonyms=Tim17b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10339406; DOI=10.1006/jmbi.1999.2751;
RA   Bauer M.F., Gempel K., Reichert A.S., Rappold G.A., Lichtner P.,
RA   Gerbitz K.-D., Neupert W., Brunner M., Hofmann S.;
RT   "Genetic and structural characterization of the human mitochondrial inner
RT   membrane translocase.";
RL   J. Mol. Biol. 289:69-82(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen,
RC   and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC       mediates the translocation of transit peptide-containing proteins
CC       across the mitochondrial inner membrane.
CC   -!- SUBUNIT: Component of the TIM23 complex at least composed of TIMM23,
CC       TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the
CC       TIMM44 component of the PAM complex. The complex also interacts with
CC       DNAJC15 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR   EMBL; AF106621; AAD19595.1; -; mRNA.
DR   EMBL; BC008275; AAH08275.1; -; mRNA.
DR   CCDS; CCDS29978.1; -.
DR   RefSeq; NP_035721.1; NM_011591.5.
DR   AlphaFoldDB; Q9Z0V7; -.
DR   BioGRID; 204200; 3.
DR   STRING; 10090.ENSMUSP00000033498; -.
DR   iPTMnet; Q9Z0V7; -.
DR   PhosphoSitePlus; Q9Z0V7; -.
DR   EPD; Q9Z0V7; -.
DR   jPOST; Q9Z0V7; -.
DR   MaxQB; Q9Z0V7; -.
DR   PaxDb; Q9Z0V7; -.
DR   PRIDE; Q9Z0V7; -.
DR   ProteomicsDB; 258878; -.
DR   Antibodypedia; 25886; 77 antibodies from 19 providers.
DR   DNASU; 21855; -.
DR   Ensembl; ENSMUST00000033498; ENSMUSP00000033498; ENSMUSG00000031158.
DR   GeneID; 21855; -.
DR   KEGG; mmu:21855; -.
DR   UCSC; uc009sne.1; mouse.
DR   CTD; 10245; -.
DR   MGI; MGI:1343176; Timm17b.
DR   VEuPathDB; HostDB:ENSMUSG00000031158; -.
DR   eggNOG; KOG1652; Eukaryota.
DR   GeneTree; ENSGT00390000017780; -.
DR   HOGENOM; CLU_087811_1_1_1; -.
DR   InParanoid; Q9Z0V7; -.
DR   OMA; CPWVILS; -.
DR   OrthoDB; 1590221at2759; -.
DR   PhylomeDB; Q9Z0V7; -.
DR   TreeFam; TF106195; -.
DR   BioGRID-ORCS; 21855; 4 hits in 70 CRISPR screens.
DR   PRO; PR:Q9Z0V7; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q9Z0V7; protein.
DR   Bgee; ENSMUSG00000031158; Expressed in internal carotid artery and 261 other tissues.
DR   ExpressionAtlas; Q9Z0V7; baseline and differential.
DR   Genevisible; Q9Z0V7; MM.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISO:MGI.
DR   GO; GO:0005743; C:mitochondrial inner membrane; HDA:MGI.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; ISO:MGI.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   InterPro; IPR005678; Tim17.
DR   TIGRFAMs; TIGR00980; 3a0801so1tim17; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Protein transport; Reference proteome; Translocation; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..172
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit Tim17-B"
FT                   /id="PRO_0000210288"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          147..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        9..78
FT                   /evidence="ECO:0000250|UniProtKB:P39515"
SQ   SEQUENCE   172 AA;  18352 MW;  F5B1E31FD37469C2 CRC64;
     MEEYAREPCP WRIVDDCGGA FTMGVIGGGV FQAIKGFRNA PVGIRHRFRG SVNAVRIRAP
     QIGGSFAVWG GLFSTIDCGL VRLRGKEDPW NSISSGALTG AVLAARSGPL AMVGSAMMGG
     ILLALIEGVG ILLTRYTAQQ FRNAPPFLED PSQLTPKEGS PAPGYPNYQQ YH