TI214_ACOCL
ID TI214_ACOCL Reviewed; 1913 AA.
AC Q3V4X6;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 35.
DE RecName: Full=Protein TIC 214 {ECO:0000250|UniProtKB:P56785};
DE AltName: Full=Translocon at the inner envelope membrane of chloroplasts 214 {ECO:0000250|UniProtKB:P56785};
DE Short=AtTIC214 {ECO:0000250|UniProtKB:P56785};
GN Name=TIC214 {ECO:0000250|UniProtKB:P56785}; Synonyms=ycf1;
OS Acorus calamus (Sweet flag).
OG Plastid; Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Acoraceae; Acorus.
OX NCBI_TaxID=4465;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15930156; DOI=10.1093/molbev/msi173;
RA Goremykin V.V., Holland B., Hirsch-Ernst K.I., Hellwig F.H.;
RT "Analysis of Acorus calamus chloroplast genome and its phylogenetic
RT implications.";
RL Mol. Biol. Evol. 22:1813-1822(2005).
CC -!- FUNCTION: Involved in protein precursor import into chloroplasts. May
CC be part of an intermediate translocation complex acting as a protein-
CC conducting channel at the inner envelope.
CC {ECO:0000250|UniProtKB:P56785}.
CC -!- SUBUNIT: Part of the Tic complex. {ECO:0000250|UniProtKB:P56785}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC {ECO:0000250|UniProtKB:P56785}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TIC214 family. {ECO:0000305}.
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DR EMBL; AJ879453; CAI53852.1; -; Genomic_DNA.
DR RefSeq; YP_319821.1; NC_007407.1.
DR AlphaFoldDB; Q3V4X6; -.
DR GeneID; 3677395; -.
DR GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR008896; TIC214.
DR PANTHER; PTHR33163; PTHR33163; 2.
DR Pfam; PF05758; Ycf1; 2.
PE 3: Inferred from homology;
KW Chloroplast; Membrane; Plastid; Plastid inner membrane; Protein transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1913
FT /note="Protein TIC 214"
FT /id="PRO_0000262599"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 245..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1605..1652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1628..1645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1913 AA; 226803 MW; 932DF86DF9602F15 CRC64;
MIFKSFLLGN LGSLYIKIIN SVVVVGLYYG FLTTFSIGPS YFFLLRARIM EEGTEREVSA
TTGFITGQLM MFISIYYAPL HLALGRPHTI TVLVIPYLLF HFFSNNQKQF FDYGSTTRNS
MRNLSIQCVF LTNLIFQLFN HLMLPSSTLA RLVNIYMFRC NNKMLFVTSS FVGWLIGHIL
FMKWVGLVVS WIRQNHSIRS NVLIRSNKYL GLKLKSAIAQ ILSIIFFIAC VNYLARLPDP
SVTKKLNETS KTETEEEESK ESQKSKESEE ERDVEKETTS ETKETKQEQE GSTEQDPSPY
WEEKEDPDKI DETEEIRVNG KEKKKDETEE IRVNGKEKKK DEFRFHFKET DYKRSPGYEN
SYLDGYQDNW DLQSEEEEEE ESTLGFEKPL VTCLFDYKRW NRPFRYIKNK TFENAIRDEM
SQYFFYTCLN NGKKKISFTY PPSLATFSEI IERKMSLYTT KKLTDDDLYS HWVSNNEEKK
NNLSNELINR IKVLDKGSLA PDVLEKRTRL CDDENEQECL PKKYDPLLNG SYRGRIKKLE
SESTRNDSII SAKGSLEKIW KNKIHSLITN DSREFEHQMD PFDGESLSAY MTHSLTSISK
LSLELVSIFH FEDLALLTEQ KRIDFENQTK RLKFLFDVIT ADANNQTIEN KFIEIEKIDK
KIPRWVYKLI SEEDYLAQQE QQEEENEEEA PLDFGIRSRK GRRVVIYTDK NQNRDQDPNP
NTDNTTTEND NSDTGEEIAL IRYAQQSDFS RDLINGSIRA KRRKIVLWEM LQANAHSPLF
LDQVAKMVSF DLFDDLRETM NLIFRNWITK EPELQILDSE EKEDREKLIK IREEDERIII
SETWDNVMCA QAIRGCMLVT HSFIRKYIIL PLLIIAKNIG RILLFQLSEW DEDFKDWNRE
MHVKCTYNGV QLSETEFPQN WLKDGIQIKI LFPFSLKPWR ESKATPSTGG LMKEKKRKND
DFCFLTVWGM EAELPFGPPR NRPSFFKPIF EELDTNIRKV ENQSFVFKEK TKDFLKKKTG
WVTKIVLLKN KIRNFFTKVN PNLLFGLKKV YEPSENQKDS IISNKITHES TVQIPSSNWT
NYSPIEKKMK DLSDRTITTR SQIERITKDK QKGFLTSDIN IRSNETSCNA KRTELQKDIL
RIAKKRSIRF IRKLHSFVKS FIERIYLDIF LCTINIPRIN LQLFFESIKK ILNKSISNDE
RNKEKIDETN QNTIHFISTI RNSFSNSNLN NKSKIYWDFS LLSQAYVLYK LSQTQVIKRY
QLKSVLQYHR AYPFLKDRIK DLFGTPRIVH AKSRPKKLPI SRINAWKNWL RGHYQYNLSQ
TRWSELVPKK WREKFNQRTI KNKYSRKLNS SEKEKNQQAH YAKEISYVVD SLSSQKGKLK
KDYRYDLLSH KYINSNYEDR EYSDISRLSL QINGDREIPY DYNRQESDYV LVGLPISDYL
GEEYFIGVDK NSDRKYFDRR ILRFDLRKDL NIKTQINRDT ETNMNKNGTN NYPAIGKKNP
FSLPIHQEIN SSKKKKQKFF DWMGMREEIL YRPISNLEPW FFPEFVLRYD AYKSKPRIIS
IKSLLLDSQK DERNEIISKT KNINKKNQKK DLSNQKKHLE VENQEKEDFR QVDLRPNPTN
QRDPIVSDTR NQQKDIEEDS VGSGVKKRRK KKKFKSKKEA ELDFFLKKYL LFQLRWDELL
NKKMMTNIKV YCLLLRLKNL KEIAISSIER GEMCLDLMLM QKDLSLRELI KKGIFIIEPI
RLSRKWDGKL IMYQTIGISL VAENKDPINI RCRKKGYADE NSFNKSVRQQ EKMLVDRDEN
DYDLLVPENI LSPRRRRELR ILICFNSGNE SAVDGNSVFY NNKNVESCRQ FLDEDKHLDT
DAKKFMKLKF FLWPNYRLED LACMNRYWFD TTNGSRFSML RIHMYPRFLI SWW
