ID   TI214_CUSEX             Reviewed;        1634 AA.
AC   A8W3G9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Protein TIC 214 {ECO:0000250|UniProtKB:P56785};
DE   AltName: Full=Translocon at the inner envelope membrane of chloroplasts 214 {ECO:0000250|UniProtKB:P56785};
DE            Short=AtTIC214 {ECO:0000250|UniProtKB:P56785};
GN   Name=TIC214 {ECO:0000250|UniProtKB:P56785}; Synonyms=ycf1;
OS   Cuscuta exaltata (Tall dodder).
OG   Plastid.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Convolvulaceae; Cuscuteae; Cuscuta;
OC   Cuscuta subgen. Monogynella.
OX   NCBI_TaxID=476139;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17956636; DOI=10.1186/1471-2229-7-57;
RA   McNeal J.R., Kuehl J.V., Boore J.L., dePamphilis C.W.;
RT   "Complete plastid genome sequences suggest strong selection for retention
RT   of photosynthetic genes in the parasitic plant genus Cuscuta.";
RL   BMC Plant Biol. 7:57-57(2007).
CC   -!- FUNCTION: Involved in protein precursor import into chloroplasts. May
CC       be part of an intermediate translocation complex acting as a protein-
CC       conducting channel at the inner envelope.
CC       {ECO:0000250|UniProtKB:P56785}.
CC   -!- SUBUNIT: Part of the Tic complex. {ECO:0000250|UniProtKB:P56785}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC       {ECO:0000250|UniProtKB:P56785}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TIC214 family. {ECO:0000305}.
CC   -!- CAUTION: Young tissue from this organism is photosynthetic and contains
CC       some thylakoids, although the photosynthetic activity does not exceed
CC       the light compensation point. {ECO:0000305}.
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DR   EMBL; EU189132; ABW83740.1; -; Genomic_DNA.
DR   RefSeq; YP_001542576.1; NC_009963.1.
DR   AlphaFoldDB; A8W3G9; -.
DR   PRIDE; A8W3G9; -.
DR   GeneID; 5729615; -.
DR   GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR008896; TIC214.
DR   PANTHER; PTHR33163; PTHR33163; 3.
DR   Pfam; PF05758; Ycf1; 2.
PE   3: Inferred from homology;
KW   Chloroplast; Membrane; Plastid; Plastid inner membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1634
FT                   /note="Protein TIC 214"
FT                   /id="PRO_0000326569"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          216..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1365..1395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1634 AA;  194375 MW;  A2C6F4CF86387663 CRC64;
     MEKKTNKNKG VAEETKKKVA ATTGFIIGQF IRFISIYYAP LYVALGRPHT ITILALPYLL
     IHLFWNTDKS FFAYDSKKLN SIRNLEISSV FLNHFILQLL NSCILPNSTL ARLITIYMFR
     CNNKILFLTS SFFAWFIGQI FMLNSFELVL VWIRKKNYLR STFRNYLLRN SIFVILFNCL
     FGSLLFILSI QCLGRIPSPI PTQKLSEVSK IEQRERERLQ SEEERDVEKK KPDYKLPDSE
     SEILQKNESE TPEFEKHLAA LLFDYKRWTR PFRYIKNNRL EQALRNELSQ YFFDTYQSDG
     KNRLSFTHPI SLSTFLKMMK LKIPLLLVEK TLYNPLDNGW VSRNKKQMNY RRIYFLNRVN
     NLDKAVALPR IQFETTRTRL CIHNDETKQE YLPENYDPLL TGPHRGRIKR GLLTINDTLT
     INDTLSEHLR ETIILNRLHA LVLLNTNSKN FNQKMYTFEK KPLEISDFST LSSNLNLTDP
     DQKTEFLVNP IETHDPNFIR KYIPIEEIRK NAPRWSYKLI TELEQISYYK NPPEDHDIRS
     RKGISVVIFD PTKEAATTNS KTNTTKDTNL ETKNKSKSDE KLVVIRYPQQ SDFRQGLIKD
     SMRTQRRKIF LQELFNANVH SPLFFDRLRI VFSFPRLKQI FINLSARHVF GILKSTDKQT
     KRKRTKKEEK GENKRREQKE RLEIGEAWDV FPLAQIIRGL LLLTQSFIRK KIILPSLILG
     KNIGRILLCQ IPEWSEDLQE WNRETHIKCT YNGIPLSQKK FPENWLTEGI QIKILFPFCL
     KPWHAYKPRT SHYDFCFLTV WGRETEQPFG HPRKTPFFFE PVLQELDKKI VNIKARIFSK
     VKINLFKRVS KENDFQIRKQ IMNESFRQIE EIPSCTNSSL IEKMRNMSDR TRTIKKKIER
     MTEDKKKVTL ELYISTYKRS YRLALSKTIC KMVKVLIWKF SYFQKLLNQR VYNDIFLYTI
     YICRMTTQLF LESTKKFISK SILKNERTKK RININKETKN KIHFLSKLKT SKNCKKNLDL
     SCDFSNLSQA YVFYKISQTG VLNICKLISV LQHTVISFFI QTQIKDLVHT EGIFKSEVIH
     QKLQWPKTSQ WKNWLRLNSK YDLSPIFWFS LISQKQKWRN RVTKYHRPKE KYLNKWNSHG
     KYRLSDYKKQ NVPKSVSNQK DNSKKCYQYD LLSYKSINYE KKSASVLYRS TPKVTKGQAI
     YHNDNMSQNY LFAITPNIPG KIKRVDIPYI GKNLDRKYLI WKNIHFSLRK KVDIESWVAV
     NTSSNKDSTI GNYNYQLIDQ IDKKEKELFS LPIHQNTEIN RPNSTNSLVD WMGMNEQILN
     RPITNLELWF FPEFVWLFNV YKTKPWIIPS KILLLNSNLS EIDSQQKSET DSETDSQQKN
     IAETQKYLEE DSTKSDTKKE TELELELFTK KYFLFQLRGD QTFNKSFFKN IQIYCLLLRL
     RNRKKMTLSC IQRRKLNLRI MPSMTNLLNV PEFLKRTGLV MDPLPLSIKT DGKFLLYKIV
     GISLVHKSKD QTNKKYRKTR IIRAVENNHL DVLVLENILS SRCRRELRTL ICFNYKNWNG
     VNTTSIFCSK NCNLFWEERN PRQNDKRELI QKFIWPNYRL EDLACMNRYS FDTTNGSRFS
     ILRFHMYLPR KIHG