ID   TI214_GOSBA             Reviewed;        1889 AA.
AC   A0ZZ93;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Protein TIC 214 {ECO:0000250|UniProtKB:P56785};
DE   AltName: Full=Translocon at the inner envelope membrane of chloroplasts 214 {ECO:0000250|UniProtKB:P56785};
DE            Short=AtTIC214 {ECO:0000250|UniProtKB:P56785};
GN   Name=TIC214 {ECO:0000250|UniProtKB:P56785}; Synonyms=ycf1;
OS   Gossypium barbadense (Sea-island cotton) (Egyptian cotton).
OG   Plastid; Chloroplast.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX   NCBI_TaxID=3634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17159292; DOI=10.1266/ggs.81.311;
RA   Ibrahim R.I.H., Azuma J., Sakamoto M.;
RT   "Complete nucleotide sequence of the cotton (Gossypium barbadense L.)
RT   chloroplast genome with a comparative analysis of sequences among 9 dicot
RT   plants.";
RL   Genes Genet. Syst. 81:311-321(2006).
CC   -!- FUNCTION: Involved in protein precursor import into chloroplasts. May
CC       be part of an intermediate translocation complex acting as a protein-
CC       conducting channel at the inner envelope.
CC       {ECO:0000250|UniProtKB:P56785}.
CC   -!- SUBUNIT: Part of the Tic complex. {ECO:0000250|UniProtKB:P56785}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC       {ECO:0000250|UniProtKB:P56785}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TIC214 family. {ECO:0000305}.
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DR   EMBL; AP009123; BAF41305.1; -; Genomic_DNA.
DR   RefSeq; YP_913244.1; NC_008641.1.
DR   AlphaFoldDB; A0ZZ93; -.
DR   PRIDE; A0ZZ93; -.
DR   GeneID; 4575304; -.
DR   GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR008896; TIC214.
DR   PANTHER; PTHR33163; PTHR33163; 1.
DR   Pfam; PF05758; Ycf1; 1.
PE   3: Inferred from homology;
KW   Chloroplast; Membrane; Plastid; Plastid inner membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1889
FT                   /note="Protein TIC 214"
FT                   /id="PRO_0000326575"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          255..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1610..1633
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        273..295
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1611..1625
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1889 AA;  224997 MW;  4E9DCF09F314C8F3 CRC64;
     MILKSFIPGN LISLYMTIIN SVVMVGLYYG FLTTLSIGPS YIFLLRARFM EEGEEGTEKR
     VSATTGFIAG QLMMFISIYY VPLHLALGKP HTITVLALPY LLFHFFWNNH KDFFDHRRPT
     RNSMRNLSIQ CVFLNNLIIQ LFNHFILPSS MLARLVNIYM FRCNNNMLFV TSSFVGWLIG
     HILLMKWVGL VLVWIQQNNL IRSNVLIRSN KYLVSEFRNS MARIFSILLF ITCVYYLGRI
     PSPILTKKLK GISEPEEVGE SEEERNIEIE TISEGGGANQ KQGTEENTSS SLFSEEEVDP
     SKETEKLRVT GKKKKKIKGE FHFRFKETYY KNRPVYETSY LDGNQESSKL EILKKKEDKY
     LLWIEKPLVT LLFDSKRWNR PLRYIKNDRV ENAIKNEMSQ YFFYTCQSDG KEKISFTYPP
     SLATFGEMIQ KKIYFFTPEK WFSDELYTDW SFINELKRRN LSKEFIKRVE SLDKESFDLG
     ILEKRTRFSN NETKREYLPK LYDPFLHGPY RGRIKKWGSP LSINQTYKKK NTDPSWINKI
     HALLLTTDYH DLEQTLDTLN IKSLATEKEL SLLTLTEDEQ GDSEDRVKIL KFLFNIVITN
     PNNQTIRKKS IGIKEISKKV PRWSYKLIDD LEQQEGENEE NVTAEHEIRS RKSKRVVIFT
     NNQANADTYT NTKDAIDPDQ TDEVALIRYS QQSDFRRDII KGSMRAQRRK TITWELFQAN
     VHSPLCLDRV DKPLFFSFDI SGPLKRISRN WICKNKESKI SDYTEKKIEK KDEAKREKYK
     REEKMRIEIA EAWDSLLLAQ VIRGSVLITQ SILRKYIILP SLIIVKNIAR MLLFQFPEWS
     EDLTDWNREM HVKCTYNGVQ LSETEFPKNW LTDGIQIKIL FPFCLKPWHR FKLQPSHKDP
     MKKKKGQKND FCFLTVWGME TELPFGSPRK RRSFFEPIFK ELKKKIKKWK TKCFIALTIL
     KEKTKLFRKA SKETKKWITQ SILFLKGIIK ELSKINPIPF FGLREPYELG ETKKDSIISN
     KMIHKSSLQI QSMSWTNYSL TEKKIKDLTK RTNTIKNQIQ KILIIKDKKN EFLTQEINSS
     SNKISYQDKI LESSKKFWQI VKRRNIRLIR KFYFFINFFI EKIYMDILLY IINIPRTNTQ
     LFLESTKKMI ENFIHNNEAN QERINKTTKN TTHFISTIKT SLSSLSNISI RNKNEKAFCD
     LSSLSQAYVF YKLSQTQVIS FYKFKPILQY HGTSLFLKNE IKDYFEERGV SHSRLRHHYG
     LRQKIVWHSG MNEWKNWLRS RYQYDLVQNR WLKLGPGQWR NGVNQHYLAQ NKHLPKWDSD
     EKERLIHYEK KNDFQANSLL TQEYKLNQEQ KYKKSNFKKH YGYDFLSYKS INYQDKRDPY
     AYGSPFQVNK REESSYHYNM DKQNFFDTLR DIPIHNYLGE GDILDAMGNF SHRKFFNWRI
     LDFCLRNKVD IESWVDTSTK SKKNIKTVVK NYQIIDKMDL FYFTIYQDQE SNPSNKKGSH
     FDWMGLNEEI LSHPIPNLEL WFFPEFVLLY NAYKVKPWII PIKLLLFNFN GNRNINKNII
     ENKKRDSLIA PNEKQIIGLE NRNQEEKEPI GEGGLVSDAQ KQGNFKSVLS NQEKDVEEDY
     DKSDKKKRRK KKQYKSNTEA ELDFFLKRYL RFQLRWDDSL NQRIINNIKV YCLLLRLINP
     NEIVISSIQR GEMNLDILMI QKDLTLRELM KKGILIIDPV RLSVKNDGQF ILYQTISILL
     VHKNKHQINQ RYQEKNYIDK NHFYEFIARH QKMTENKDKN HYDLFVPENI LSPNHRRELR
     IRISFNSRDK NGMHRNAVFL NNVKNCGQVL TKNKHLDSDK KKLIKLKFFL WPNYRLEDLA
     CMNRYWFNTN NGSRFSMIRI RMYPRLKIR