TI214_GOSHI
ID TI214_GOSHI Reviewed; 1892 AA.
AC Q2L951; Q5U724;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2006, sequence version 1.
DT 25-MAY-2022, entry version 38.
DE RecName: Full=Protein TIC 214 {ECO:0000250|UniProtKB:P56785};
DE AltName: Full=Translocon at the inner envelope membrane of chloroplasts 214 {ECO:0000250|UniProtKB:P56785};
DE Short=AtTIC214 {ECO:0000250|UniProtKB:P56785};
GN Name=TIC214 {ECO:0000250|UniProtKB:P56785}; Synonyms=ycf1;
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OG Plastid; Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Coker 310FR;
RX PubMed=16553962; DOI=10.1186/1471-2164-7-61;
RA Lee S.-B., Kaittanis C., Jansen R.K., Hostetler J.B., Tallon L.J.,
RA Town C.D., Daniell H.;
RT "The complete chloroplast genome sequence of Gossypium hirsutum:
RT organization and phylogenetic relationships to other angiosperms.";
RL BMC Genomics 7:61-61(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1298-1669.
RA Bashir A., Samad A.;
RT "Association of plastid genome with developing cotton fibers.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in protein precursor import into chloroplasts. May
CC be part of an intermediate translocation complex acting as a protein-
CC conducting channel at the inner envelope.
CC {ECO:0000250|UniProtKB:P56785}.
CC -!- SUBUNIT: Part of the Tic complex. {ECO:0000250|UniProtKB:P56785}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC {ECO:0000250|UniProtKB:P56785}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TIC214 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ345959; ABC73674.1; -; Genomic_DNA.
DR EMBL; AY800381; AAV48874.1; -; Genomic_DNA.
DR RefSeq; YP_538982.1; NC_007944.1.
DR AlphaFoldDB; Q2L951; -.
DR GeneID; 3989233; -.
DR KEGG; ghi:3989233; -.
DR Proteomes; UP000189702; Chloroplast Pltd.
DR GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR008896; TIC214.
DR PANTHER; PTHR33163; PTHR33163; 1.
DR Pfam; PF05758; Ycf1; 1.
PE 3: Inferred from homology;
KW Chloroplast; Membrane; Plastid; Plastid inner membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1892
FT /note="Protein TIC 214"
FT /id="PRO_0000262609"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1115..1135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 256..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1613..1636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1614..1628
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 1298..1301
FT /note="GPGQ -> IRGK (in Ref. 2; AAV48874)"
FT /evidence="ECO:0000305"
FT CONFLICT 1472
FT /note="V -> G (in Ref. 2; AAV48874)"
FT /evidence="ECO:0000305"
FT CONFLICT 1485..1502
FT /note="YFTIYQDQESNPSNKKGS -> ISQFIKIKKATHPIKKER (in Ref. 2;
FT AAV48874)"
FT /evidence="ECO:0000305"
FT CONFLICT 1641..1645
FT /note="TEAEL -> AVIIN (in Ref. 2; AAV48874)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1892 AA; 225548 MW; BCC05E17F84AF518 CRC64;
MMILKSFIPG NLISLYMTII NSVVMVGLYY GFLTTLSIGP SYIFLLRARF MEEGEEGTEK
RVSATTGFIA GQLMMFISIY YVPLHLALGK PHTITVLALP YLLFHFFWNN HKDFFDHRRP
TRNSMRNLSI QCVFLNNLII QLFNHFILPS SMLARLVNIY MFRCNNNMLF VTSSFVGWLI
GHILLMKWVG LVLVWIQQNN LIRSNVLIRS NKYLVSEFRN SMARIFSILL FITCVYYLGR
IPSPILTKKL KGISEPEEVG ESEEERNIEI ETISEGGGAN QKQGTEENTS SSLFSEEEVD
PSKETEKLRV TGKKKKKIKG EFHFRFKETY YKNRPVYETS YLDGNQESSK LEILKKKEDK
YLLWIEKPLV TLLFDSKRWN RPLRYIKNDR VENAIKNEMS QYFFYTCQSD GKEKISFTYP
PSLATFGEMI QKKIYFFTPE KWFSDELYTD WSFINELKRR NLSKEFIKRV ESLDKESFDL
GILEKRTRFS NNETKREYLP KLYDPFLHGP YRGRIKKWGS PLSINQTYKK KNTDPFWINK
IHALLLTTDY HDLEQTLDTL NIKSLATEKE LSLLTLTEDE QGNIDSEDRV KILKFLFNIV
ITNPNNQTIR KKSIGIKEIS KKVPRWSYKL IDDLEQQEGE NEENVTAEHE IRSRKSKRVV
IFTNNQANAD TYTNTKDAND PDQTDEVALI RYSQQSDFRR DIIKGSMRAQ RRKTITWELF
QANVHSPLFL DRVDKPLFFS FDISGPLKRI SRNWICKNKE SKISDYTEKK IEKKDEAKRE
KYKREEKMRI EIAEAWDSLL LAQVIRGSVL ITQSILRKYI ILPSLIIVKN IARMLLFQFP
EWSEDLTDWN REMHVKCTYN GVQLSETEFP KNWLTDGIQI KILFPFCLKP WHRFKLQPSH
KDPMKKKKGQ KNDFCFLTVW GMETELPFGS PRKRRSFFEP IFKELKKKIK KWKTKCFIAL
TILKEKTKLF RKASKETKKW ITQSILFLKG IIKELSKINP IPFFGLREPY ELGETKKDSI
ISNKMIHKSS LQIQSMAWTN YSLTEKKIKD LTKRTNTIKN QIQKILIIKD KKNEFLTQEI
NSSSNKISYQ DKILESSKKF WQIVKRRNIR LIRKFYFFIN FFIEKIYMDI LLYIINIPRT
NTQLFLESTK KMIENFIHNN EANQERINKT TKNTTHFIST IKTSLSSLSN ISIRNKNEKA
FCDLSSLSQA YVFYKLSQTQ VISFYKFKPI LQYHGTSLFL KNEIKDYFEE RGVSHSRLRH
HYGLRQKIVW HSGMNEWKNW LRSRYQYDLV QNRWLKLGPG QWRNRVNQHY LAQNKHLTKW
DSDEKERLIH YEKKNDFQAN SLLTQEYKLN QEQKYKKSNF KKHYGYDFLS YKSINYQDKR
DPYAYGSPFQ VNKREESSYH YNMDKQNFFD TLRDIPIHNY LGEGDILDAM GNFSHRKFFN
WRILDFCLRN KVDIESWVDT STKSKKNIKT VVKNYQIIDK MDLFYFTIYQ DQESNPSNKK
GSHFDWMGLN EEILSHPIPN LELWFFPEFV LLYNAYKVKP WIIPIKLLLF NFNGNRNINQ
NIIENKKRDS LIAPNEKQII GLENRNQEEK EPIGEGGLVS DAQKQGNFKS VLSNQEKDVE
EDYDKSDKKK RRKKKQYKSN TEAELDFFLK RYLRFQLRWD DSLNQRIINN IKVYCLLLRL
INPNEIVISS IQRGEMNLDI LMIQKDLTLR ELMKKGILII DPVRLSVKND GQFILYQTIS
ILLVHKNKHQ INQRYQEKNY IDKNHFYEFI ARHQKMTENK DKNHYDLFVP ENILSPNHRR
ELRIRISFNS RDKNGMHRNA VFLNNVKNCG QVLTKNKHLD SDKKKLIKLK FFLWPNYRLE
DLACMNRYWF NTNNGSRFSM IRIRMYPRLK IR
