ID   TI214_LACSA             Reviewed;        1673 AA.
AC   Q1KXH4;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Protein TIC 214 {ECO:0000250|UniProtKB:P56785};
DE   AltName: Full=Translocon at the inner envelope membrane of chloroplasts 214 {ECO:0000250|UniProtKB:P56785};
DE            Short=AtTIC214 {ECO:0000250|UniProtKB:P56785};
GN   Name=TIC214 {ECO:0000250|UniProtKB:P56785}; Synonyms=ycf1;
OS   Lactuca sativa (Garden lettuce).
OG   Plastid; Chloroplast.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC   Lactucinae; Lactuca.
OX   NCBI_TaxID=4236;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Salinas;
RA   Timme R.E., Kuehl J.V., Boore J.L., Jansen R.K.;
RT   "A comparison of the first two published chloroplast genomes in Asteraceae:
RT   Lactuca and Helianthus.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in protein precursor import into chloroplasts. May
CC       be part of an intermediate translocation complex acting as a protein-
CC       conducting channel at the inner envelope.
CC       {ECO:0000250|UniProtKB:P56785}.
CC   -!- SUBUNIT: Part of the Tic complex. {ECO:0000250|UniProtKB:P56785}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC       {ECO:0000250|UniProtKB:P56785}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TIC214 family. {ECO:0000305}.
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DR   EMBL; DQ383816; ABD47280.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1KXH4; -.
DR   GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR008896; TIC214.
DR   PANTHER; PTHR33163; PTHR33163; 2.
DR   Pfam; PF05758; Ycf1; 3.
PE   3: Inferred from homology;
KW   Chloroplast; Membrane; Plastid; Plastid inner membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1673
FT                   /note="Protein TIC 214"
FT                   /id="PRO_0000262613"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1673 AA;  199812 MW;  2347BF377DAA54DE CRC64;
     MILKSFLLGN LVSLCMKIIN SVVVVGLYYG FLTTFSIGPS YLFLLRAHIM EEGEEGTEKK
     VSATTGFITG QLIMFISIYY APLHLALGRP HTITVLALPY LLFHFFCNTH KHFFDYGSTN
     RNSMRNLSIQ CVFLNNLIFQ LFNHFILPSS MLARLVNIFM FQCNNKIIFV TSSFVGWIIG
     HIILMKSIGL LVVWIRKNRS IRKYIRSNKS FVSELANSMS IAGILNILLF VTCVYYLGRM
     PLPIINKKLN NLEKMDQAKL KNNTPLSYIY KNQEDLYLEI LGKKDKEKSF SLFEKPILTF
     FFDYNRWNRP LRYIRKINKN LSVRKETSQY FFYTCQSDGK KRISFTYPPS LSTFGEMIAR
     RISLSTLEKL SADALYTEWL YTNKEKNNNL NNEFINRIEA LETVFLSINI LDTKTRLCNV
     ETEKKKNCLV NKKNYLVKMD DPFLTGMYRG RINKLFSSSI INQISIENYE KTYELNKIHY
     NLLPYPNSRE YEHKIDPNSP DYEQKIEKLE KIQAQIDLNN RFIFLWTTII AKLKGQKNSS
     RINEIGKKPP RWSYKLINEL HQNYKKRRKE QGIIQGLRHQ LRTRKYKHIY FLNRSTRTLE
     TLKQSNLNNS NMDKKFNNKD LGFISYLEEP DFRRSLIKGS MRAQRRKLVI WGPYQGNPHS
     PLFLEKKQDF PFPISDLIKL FLNIKDRLGK KSEFEILNKQ SPPKRNNQED VMEFWETIPH
     GHKTRGILLL AQSTFRKYIK LPLLIIAKNI VRILLRQSPE WDEDFQDWNR EIYLKCSSNG
     LQFSKTKFPK NWLRGGFQIK ILYPFHLKPW HRSKLRLYDS DRDLKQQEDF DSCFLTVLGM
     ETEHPFGPPR KTPSFFEPIF KDIDYKVEIR KLNFRVRRIF KKIKKKEAKA FFFIKQKIKE
     LLKGNKIPLF LPREIYESSE TQTEKDSIIS NQIIHESLSQ IRSTGWTNYS QAEEEMKHRI
     DRRKTIRNEI EIMKKNKINN AESSQKILKI LKIKNIELLV KFFIEKIYIE IFLCIINMRR
     IPLQLFIQST KKIIDNDKYI NNNETNQERI NKTKQNKIDF ILSMTIKRAF DNLRNSKRKS
     DIFFDLSYLS QKYVFFKLSQ TQIINFNKLR SILQYNGPSF CLKTEIKDFF GRQGIFHSEL
     RHNKLPNYGM NPWKNWLRGH YQYDLSQITS SRLIPQKWRN RINQCQTSQN KDLNKWYSSE
     KDQLLDSKKK QNSKVYLLPN KEDNLKKNYR YDLLSYKYIH SETKKNYYIY RSSLETNNNQ
     ENSTRNKEKF FSILKNIPSK NYLGKSDIIY MEKNKDRKFL YKINKNIKVE PNKDQIKDKN
     KDQKKDKIHN NGLFYLPIDS NLEINYKKVF FDWMGMNEKI LILNCLISNP KVFFFPKFVR
     LYHKYKEKPW FIPSKLLLFN LNITSNFSEN QNINGKQEEY FLKQEEYFLK QEEDFLKQEE
     DFLKQEEDFL KQEEDFLKQE EDFFKFRPSN SKQYFELNNQ NNIEEYFLES TEKLKIFLKG
     DFPLQLRWAG RVNQLNQKIM NNIQIYGLLL SLINVRKITI SYIQRKEMDL GIMSRNLNLT
     QLMKTGILIL EPARLSLKND GQFFMYQIIS ISLVHKSKYQ SNQRYQKQEN VAKNIDKKNS
     DLLVPEKILS SRRRRELRIL ISFNLNLKNN TGVDRNTLVY NENKIKKMES IFG