TI214_NUPAD
ID TI214_NUPAD Reviewed; 1868 AA.
AC A1XG13;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=Protein TIC 214 {ECO:0000250|UniProtKB:P56785};
DE AltName: Full=Translocon at the inner envelope membrane of chloroplasts 214 {ECO:0000250|UniProtKB:P56785};
DE Short=AtTIC214 {ECO:0000250|UniProtKB:P56785};
GN Name=TIC214 {ECO:0000250|UniProtKB:P56785}; Synonyms=ycf1;
OS Nuphar advena (Common spatterdock) (Nuphar lutea subsp. advena).
OG Plastid; Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Nymphaeales; Nymphaeaceae; Nuphar.
OX NCBI_TaxID=77108;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17573971; DOI=10.1186/1471-2164-8-174;
RA Raubeson L.A., Peery R., Chumley T.W., Dziubek C., Fourcade H.M.,
RA Boore J.L., Jansen R.K.;
RT "Comparative chloroplast genomics: analyses including new sequences from
RT the angiosperms Nuphar advena and Ranunculus macranthus.";
RL BMC Genomics 8:174-174(2007).
CC -!- FUNCTION: Involved in protein precursor import into chloroplasts. May
CC be part of an intermediate translocation complex acting as a protein-
CC conducting channel at the inner envelope.
CC {ECO:0000250|UniProtKB:P56785}.
CC -!- SUBUNIT: Part of the Tic complex. {ECO:0000250|UniProtKB:P56785}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC {ECO:0000250|UniProtKB:P56785}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TIC214 family. {ECO:0000305}.
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DR EMBL; DQ354691; ABC60517.1; -; Genomic_DNA.
DR RefSeq; YP_001001592.1; NC_008788.1.
DR AlphaFoldDB; A1XG13; -.
DR PRIDE; A1XG13; -.
DR GeneID; 4699575; -.
DR GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR008896; TIC214.
DR PANTHER; PTHR33163; PTHR33163; 1.
DR Pfam; PF05758; Ycf1; 2.
PE 3: Inferred from homology;
KW Chloroplast; Membrane; Plastid; Plastid inner membrane; Protein transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1868
FT /note="Protein TIC 214"
FT /id="PRO_0000326582"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 248..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..636
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1537..1579
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1580..1594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1868 AA; 222222 MW; B6C172C0C98C1A50 CRC64;
MILKYSLLGN LLLLWMNIVN SVVLVGLYYG FLTTFSIGPS YLLLLRTRVM KEGSEKEVSA
TTAFIMGQFI IFISTYYPPL HLALSRPHTL TVLVLPYLLL HFLFFWNNHK SLFDHRSTHG
NFIPNLSIQY VFLNNLIFQL FNHFILPSST LTRLVDISMF RCNNKILFVI SSFFGWLIGH
ILLMKSIGLV LSWPWEKMRS NALFRSNKYL VSKWRNSVSQ IFSILLFITC VCYLGRMPSP
IITKKLKESS KGEEKKKTEK ERDVEMETIS KTKKIEQEEE RSVEEDLSIS LEGRWNPYKI
YETEEIRLNG KEKDEFGFKE KEKNELLWVE KSLLSLLFDY QRWNRPLRYI ENDRFSNAVR
NEMSQYFFNT CASDGKQIIS FTYPPSLSTF FEMIQKKMYF RTAEKLPAED LSNEWVSTTE
KQRDNLRNEF INRIEAIDKG SLILDVVEKR ARLCNDEEEQ ECLPKFYDPL LNGPYRGTIK
KGYLYSIRND SITSIQGSTK ISWINKIHGI LSKDYREFEH EIYKLDVKSS SAGIDDSSVS
IGEFTEEAEE AEESRTRFKQ FAFWGEEKEI NSENQAEFLF DMVRADPNDQ KISNQSIKIE
EMKKKVPRWL YKLTADFDFE EEEEEEEEED DEEEPTDDHG IRSRKAKRVV IYTDTDTDED
TDTNIINTTD SDQAKNSDQA KNSDQAKKSD QAKNSDQAEE HEMALIRYSQ QSDFRRDIIK
GSMRAQRRKT VTWEMFQTDV HSPLFLDRID KTPLFSFDIS RMMNLIFRNW MEEKSLKLKR
KTSDYAGEGA KEEEHEEEKR EYKRKEDKRQ EDERIAIAEA WDTIPFAQAV RSSLLVTHSI
LRKYIVLPSL IIVKNIGRML LFQFPEWYED FKEWSREMHV KCTYNGVQLS ETEFPKDWLT
DGIQIKILFP FSLKPWRRSK LRSHHRDLRK KQKNFCFLTV WGVETELPFG SPRKNPFFFE
PIHKTLEKKI RKVKKKGFFI LKILKDNIKG FLEIFKEKIR WVIKIVLFIK SKVIFFFRLT
RVFDPIPNNK DSKISNRIIH ESPIRIGSRD WANDSLTERK INDLADKTIK IRDQVEKIMK
DKKKKITESQ KYIWQISKKR SARLIPKWNS FMKSFIERIY MGILLCITNI YKINVKFFLD
STLDSTKKIL NRYTYNDETK EKDTNETNPN IIPFISTIKS LSTYTTTISS NSHSPIYCDL
SSLSQAYVFY KLLQTQVSNK YKSESIFQYY RTYPFIKDRI KDYFHNYFHT RGISDSESKH
KKLRNSGMNE WKNWLRNHYQ YNLSRAKWSG LAPLKWRNKV NQHRTIKNND LQKLDSYEEK
DQLIHSEIKD FYKLGLLKSP SHTKKMKKHY RYDLLSYKYI NYEYVKDSNI YGSPLQVNRH
GEILSLSNYN THKYKSFYVI TINDCLEDKY IIDTDQNLDR KYFELRIIYF YPRNDIETRT
STDIGTFTKK NKTTKTGTNK KDLYIRIHQE IQTKQKEFFF DWMGMNEQML DRTISNLDPW
FLPEFVPLYD RYRTNPWIIP IKLLLFDFNG NKKSDLYIDP KVKSNQKERS NPKAESNQKE
YLELENRNRD EKERQHQGNL ISDTRNQKKD VGANSTGSDI KKRRKKKKFK SKKEAELDLL
LKKYFLFQLR WGDSFNQRMT NNIKVYCLLL RLMDPSEIAI SSIERGEMGL DVMLIHKDLS
LPELIKRGIF IIEPVRLSTK WDGISIMYQT IAISLTHKVQ HQTNRGYQAK KHIDENYFNG
SIACHGGVRV NGDNNNYDLL VPENILSPNH RREFRIISRF NYRNRNVVNK NPVFFNRAKT
NAQGFEKFVD RDKHFDTDTN NSLKWKVFLW PTHRLEDLAC MNRYWFDTNN GSRFSMSRIH
MYQRFGIR
