TI214_NYMAL
ID TI214_NYMAL Reviewed; 1976 AA.
AC Q6EVZ2;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=Protein TIC 214 {ECO:0000250|UniProtKB:P56785};
DE AltName: Full=Translocon at the inner envelope membrane of chloroplasts 214 {ECO:0000250|UniProtKB:P56785};
DE Short=AtTIC214 {ECO:0000250|UniProtKB:P56785};
GN Name=TIC214 {ECO:0000250|UniProtKB:P56785}; Synonyms=ycf1;
OS Nymphaea alba (White water-lily) (Castalia alba).
OG Plastid; Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Nymphaeales; Nymphaeaceae; Nymphaea.
OX NCBI_TaxID=34301;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15084683; DOI=10.1093/molbev/msh147;
RA Goremykin V.V., Hirsch-Ernst K.I., Woelfl S., Hellwig F.H.;
RT "The chloroplast genome of Nymphaea alba: whole-genome analyses and the
RT problem of identifying the most basal angiosperm.";
RL Mol. Biol. Evol. 21:1445-1454(2004).
CC -!- FUNCTION: Involved in protein precursor import into chloroplasts. May
CC be part of an intermediate translocation complex acting as a protein-
CC conducting channel at the inner envelope.
CC {ECO:0000250|UniProtKB:P56785}.
CC -!- SUBUNIT: Part of the Tic complex. {ECO:0000250|UniProtKB:P56785}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC {ECO:0000250|UniProtKB:P56785}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TIC214 family. {ECO:0000305}.
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DR EMBL; AJ627251; CAF28654.1; -; Genomic_DNA.
DR RefSeq; YP_053214.1; NC_006050.1.
DR AlphaFoldDB; Q6EVZ2; -.
DR GeneID; 2896244; -.
DR GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR008896; TIC214.
DR PANTHER; PTHR33163; PTHR33163; 2.
DR Pfam; PF05758; Ycf1; 3.
PE 3: Inferred from homology;
KW Chloroplast; Membrane; Plastid; Plastid inner membrane; Protein transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1976
FT /note="Protein TIC 214"
FT /id="PRO_0000262619"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1054..1074
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1202..1222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 619..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1633..1669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..634
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..861
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1976 AA; 234279 MW; 8F3229BF90FCD14B CRC64;
MILKYSLLGN LLLLWINIVN SVVMVGLYYG FLTTFSIGPS YLLLLRTRVM KEGSEKEVSA
TTAFIMGQFI VFISTYYPPL HLALSRPHTL TVLVIPYLLS HFWFFWNNKK SLFDYRSTHG
NFIPNLSIQY VFLNNLIFQL FNHFVLPSST LTRLVDISMF RYNNKILFVT SSFFGWLIGH
MLLMKCIGLV LSWPWEKMRS NALFRSNKYL MSKWRNSVSQ IFSILLFIIC ICYLGRMPSP
IITKKLKESS KREEKKKTEE EGNVEIERVS KTNKIKQEED GSVEEDLSIS LEMEERWNLY
KKIYETEEIW LNGKEKDEFD LKEKEKNKLL GIEKSLLSLL FDYQRWNRPL RYIENDRFSN
AVRNEMSQSF FYTCASDGKQ RISFTYPPSL STFFEMIKKK MSFRTAEKLP AEDLSNEWVS
TTKKQRDNLR NEFINRIEAI DKGSLILNVV EKRARLCNDE EEQECLPKFY DPLLNGPYRG
TRKKGYLYSI RNDSTTSTRG STKTAWINKI HAILFSKDYR EFEREFEHEM YKLGVKSSST
GIEDSSVSIG EFTEEAEEAE KSRTRFKQFA FGGEEKVFEK VFDMVRADPN DQKISNLPIE
EIKKKVPRWL YKLTSDLDFE EEEEEEEEDD QEESTDDHGI RSRKGKRVVI YTDTNQGTNI
INTTNNIIKT HDNIIKTTND NIIKTTTDNI INTNDNIIKT TDNIINTNDN IIKTTDNIIN
TNDNIIKTTD SNREKNSDDK VENGDQAEEN EMALIRYSQQ SDFRRDLIKG SMRAQRRKTV
TWEMFQTDAH SPLFFDRIDK TPLFSFDISR MMNLIFRNWM EEKSPKMKTS SYVGEGAKEK
EKIEEEHEEE KGEYKRKEDK RQEEERIAIA ETWDNIIFAQ AIRGSILVTH SILRKYIVLP
SLIIVKNIGR MLLFQFPEWY EDFNEWSREM HVKCTYNGVQ LSETEFPKDW LTDGIQIKIL
FPFSLKPWHR SKLRSHHKDL RKKQKNFCFL TIWGMETELP FGSPRKKPFF FEPIHKAFEK
KIIKVKKKGF FFLIIIKDNI KGFIKILNEK IRWIIKIVLF IKIKVKEVFF FFVLRRVSDP
SQNEEPSKNE KDSKISNRII HESPIRIVSR DWTNDSLIEI KINDLADKTT KIWDQVEKIR
KDKKKKPLTP DIEDIDISTN KGNCSNKRTE SRKHIWQISK KRRSARLISK WDSFMKSFIE
RIYMSILLCI TNIYRIYVQF FLDSTKKTLN GYTYNDEIKE KDTNEPNPNI IPFISTVKSL
STYTTNISSD SNSPIYCDLS SLSQAYVFYK LLQTQVSNKY KSESIFHYYR TYPFIKDGIK
DYFHDYFHTR GIFDSESKHK KLRNSGMSEW KNWLKSHYQY NLSHDKWSRL APLKWRKKVN
QHRTIQNNDS PKSGSYEEKD QLIHSGKKDY SKLGLLKSPS REMKSPSREK KIKKHYRYDL
LSYKYLNYED VKDSNIYGSP LQVNRHGEIS NYNTHKYKSF YAITINDSLE DKYTIDRDQN
LDRKYFELRI TNFDPRNNIE TRTSTDIGTF INKKKKTTKT GTNKKDILSL YIRIHQEIQT
KQKEFFFDWM GMNEQMLDRT ISNLRPWFLP EFVPLYDRYT TNPWIIPINL ILFDFHGNKT
SDLYIDPKVE SNQKERFHPK PKVESNQKGY LELENRNRDE KERQHQGNLI SDIRNKKKDV
GANSAGSDIK KRRKKKKFKS KKEAELDLFL KKYFIFQLRW DDPFNKGMNN NIKVYCLLLR
LMNPNEIAIS SIQSGEMGLD VMLINRGFSL PELIKKGIFL IEPVRLSIKR DGISIMYQTI
AISLTHKIQH QTNQGYQLKK YIDKNYFNGS IARHGGVRVN GDNNNYDLLV PEHILSPSHR
RELRILSRFN YRNRNLVNKN PVFCNRAKTN AQGFEKFVNR DKHFHTDTNN SLKWKVFLWP
THRLEDLACM NRYWFDTNNG SRFSMSRIHM YQQFGIRGCY SQFPSLSRAW YMRTCK
