TI214_PANGI
ID TI214_PANGI Reviewed; 1919 AA.
AC Q68RU8;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=Protein TIC 214 {ECO:0000250|UniProtKB:P56785};
DE AltName: Full=Translocon at the inner envelope membrane of chloroplasts 214 {ECO:0000250|UniProtKB:P56785};
DE Short=AtTIC214 {ECO:0000250|UniProtKB:P56785};
GN Name=TIC214 {ECO:0000250|UniProtKB:P56785}; Synonyms=ycf1;
GN ORFNames=PSC1261;
OS Panax ginseng (Korean ginseng).
OG Plastid; Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Apiales; Araliaceae; Panax.
OX NCBI_TaxID=4054;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15500250; DOI=10.1093/dnares/11.4.247;
RA Kim K.-J., Lee H.-L.;
RT "Complete chloroplast genome sequence from Korea ginseng (Panax schinseng
RT Nees) and comparative analysis of sequence evolution among 17 vascular
RT plants.";
RL DNA Res. 11:247-261(2004).
CC -!- FUNCTION: Involved in protein precursor import into chloroplasts. May
CC be part of an intermediate translocation complex acting as a protein-
CC conducting channel at the inner envelope.
CC {ECO:0000250|UniProtKB:P56785}.
CC -!- SUBUNIT: Part of the Tic complex. {ECO:0000250|UniProtKB:P56785}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC {ECO:0000250|UniProtKB:P56785}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TIC214 family. {ECO:0000305}.
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DR EMBL; AY582139; AAT98568.1; -; Genomic_DNA.
DR RefSeq; YP_087024.1; NC_006290.1.
DR AlphaFoldDB; Q68RU8; -.
DR PRIDE; Q68RU8; -.
DR GeneID; 3021580; -.
DR GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR008896; TIC214.
DR PANTHER; PTHR33163; PTHR33163; 2.
DR Pfam; PF05758; Ycf1; 2.
PE 3: Inferred from homology;
KW Chloroplast; Membrane; Plastid; Plastid inner membrane; Protein transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1919
FT /note="Protein TIC 214"
FT /id="PRO_0000262620"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 250..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1606..1636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..326
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1606..1622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1919 AA; 228280 MW; 3EADCFC2C5CEF072 CRC64;
MILKSFLLGN LVSLCMKIIN SVVVVGLYYG FLTTFSIGPS YLFLLRARVM EEGEEGTEKK
VSATTGFITG QLMMFISIYY APLHLALGRP HTITVLALPY LLFHFFWNNH KNFFDYGSTT
RNSMRNLSIQ CVFLNNLIFQ LFNHFILPSS MLARLVNIYM FRCNNKMLFV TSSFVGWLIG
HILFMKWVGL VLVWIRQNHS IRSNKYIRSN KYLVSELINS MARIFSILLF ITCVYYLGRI
PSPIITKKLK ETPTTEERGE SEEETDVEIE TPTTEERGES EEETDVEIET PTTEERGESE
EETDVEIETP TTEERGESEE ETDVEIETAS ETKGAKQEQE GSTEEDPSPS LFSEEKEDPD
KIDETEEIRV NGKEKTKDEF HFTETSYNNS PVYKVSYLYK NQENFNKIKI LDKKDEDKGL
FWFEKPLVTL LFDYKRWNRP LRYIKNNRFE RTARNEMSQY FFYTCRSDGK ERISFTYPPS
LSTFGEMIQR RMSLPTLEKL SSDELYNHWI YTNKQKKNNL NNEFLNRIKA LDMGFLSLDI
LEKSTRLYND TKKDYLPKIY DPILNGSYRG TIKKKFSPSI RNKISLENFI ETMEINKIHN
LLLPDTDYQE FKQKIDPFDK KKRFSTEISH LFTLISKFDR ESRSGLNLKG PSLFSENEAK
LLKFLLNAII TIANGHKIKQ KSFGIKEISK KVPRWSDKFI TELEQQTGVI QEGVRVGHQI
RSRKIDDIVV FTDNKWNSKN RDKIDLIYTI EYLQESDFRR NIIKGSMRTQ RRKTIIWKLF
EANAHSPLFL NRRKKSPLFS FDISELMKLI FRNWMGKGAE LKDYTEEQTK RREKQEENNI
KEKVRIELPE IWDLVPFSKT TRSLLLIIQS MLRKYIILPS LIIVKNIGRI LLFQPPEWSE
DFHEWKREKH IKCTYNGVQL SETELPANWL TEGIQIKILF PFCLKPWYRS KPKLRPSYRD
LKKEQKKDDS CFLTASGMET DLPFGSPRKR TSFFEPIFKD FLALRVLIRR TKHFLQGSKE
TKRGFIKNVL FLFLKRIKKE LSKVNPTLFR LKEVYESGET NQEKGSIISN QTIHNSFNKI
RSTDNYSPRE KKIKNLTDRT SPIRKKIKSI TKEKKKGTPG IKSSPNKRSY NVESPKDIWQ
ILKRRNTRLI WKLQVFLKIF IEKIYIDIFL YIINIARMYT RLVLESTKKI IQKYKYIYNN
ETNQETINKT NQNTIHFIST IKKSLYNIRN SKKNSHLFFD LSSLSQAYVF YKLSRTRVIN
LYKLRSVLEY HGTSFFLKTA IKDSFGTQGI FHSELEHTKF PSYGTNQWKN WLRGHYQYNL
SQIRWSGLIP QKWRNTINQG RITQKKNLTK WDSKDRLLHY KKQNAFEVYS LPNPNKNENS
QKYYRYDLLS YKSINYERKT DPYIIYGSPL QVNNNQRISY NYTTQKQKFF DILEDIPINN
YLGKGDIMYM EKNPDRKYFD WKIINFFLRE KVDIETWIKM DPNSNKNTKI ESKNYQKIDK
IHKNQIFYLT LYQDLEKNPL NQKKHLFGWM EMNQEILNRH ISNLELWFFP EFVLLYNVYK
KKPWIIPSKL LLLNLNRNEN VSDNKNINGK QKWNFFRPSN EKKIFELKNR NQEEKEPADR
GDLGSDAQNQ GNRRFVLSNQ QKDIEEDYAK LVLKRGKTKK QSKNKSNVKV ELNALLKQHL
LFQLRYDEGL KQRMINNLKV SCLLIGLKNP RNITVSSIQN REISLDIMLI RKSLTVRELM
KRGVLIIEPI RLSVKKDGQF IMYQTIGISL IHKSKYQTNQ RYREQRYIDK KKFDESTPRY
QRRTGNRDKN HYDFLVPEKI LSSRRRRELR ILIHFNSRSR KGVDSNPVFC NKKNIKSRSP
FLDESKRFDR DKNELIKLKF FLGPNYRLED LACINRYWFD TNNGSNFSML RIYPQLKIR
