ID   TI214_PHYPA             Reviewed;        1603 AA.
AC   Q6YXP5;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Protein TIC 214 {ECO:0000250|UniProtKB:P56785};
DE   AltName: Full=Translocon at the inner envelope membrane of chloroplasts 214 {ECO:0000250|UniProtKB:P56785};
DE            Short=AtTIC214 {ECO:0000250|UniProtKB:P56785};
GN   Name=TIC214 {ECO:0000250|UniProtKB:P56785}; Synonyms=ycf1;
OS   Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OG   Plastid; Chloroplast.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC   Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX   NCBI_TaxID=3218;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Gransden 2004;
RX   PubMed=12954768; DOI=10.1093/nar/gkg726;
RA   Sugiura C., Kobayashi Y., Setsuyuki A., Sugita C., Sugita M.;
RT   "Complete chloroplast DNA sequence of the moss Physcomitrella patens:
RT   evidence for the loss and relocation of rpoA from the chloroplast to the
RT   nucleus.";
RL   Nucleic Acids Res. 31:5324-5331(2003).
CC   -!- FUNCTION: Involved in protein precursor import into chloroplasts. May
CC       be part of an intermediate translocation complex acting as a protein-
CC       conducting channel at the inner envelope.
CC       {ECO:0000250|UniProtKB:P56785}.
CC   -!- SUBUNIT: Part of the Tic complex. {ECO:0000250|UniProtKB:P56785}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC       {ECO:0000250|UniProtKB:P56785}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TIC214 family. {ECO:0000305}.
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DR   EMBL; AP005672; BAC85096.1; -; Genomic_DNA.
DR   RefSeq; NP_904246.1; NC_005087.1.
DR   AlphaFoldDB; Q6YXP5; -.
DR   STRING; 3218.PP1S207_91V6.1; -.
DR   PRIDE; Q6YXP5; -.
DR   GeneID; 2546760; -.
DR   KEGG; ppp:2546760; -.
DR   eggNOG; ENOG502QSDY; Eukaryota.
DR   HOGENOM; CLU_1689676_0_0_1; -.
DR   InParanoid; Q6YXP5; -.
DR   OrthoDB; 53153at2759; -.
DR   Proteomes; UP000006727; Chloroplast.
DR   GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR008896; TIC214.
DR   PANTHER; PTHR33163; PTHR33163; 2.
DR   Pfam; PF05758; Ycf1; 3.
PE   3: Inferred from homology;
KW   Chloroplast; Membrane; Plastid; Plastid inner membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1603
FT                   /note="Protein TIC 214"
FT                   /id="PRO_0000262622"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1603 AA;  192705 MW;  BEAFC73FCE19734E CRC64;
     MITNTPLQFS VLWASILSWI NISSPLILFG LYYGFLTTLP IGPSQILSIR AFLLEGNLSG
     TVAVSGLILG QLIIFLSIYY SPLYTLLLKP HTVTLLVLPY LLFYWYRIKD LLDYQSLRPI
     NSIKDSRIYK IFFDSFIFQL LNPVLLPSPI LVRLINLFFF RYSNNFLFVL SCFFGWLSGH
     LFFFNCIKFL LIRIEKDSPI LYLLVKRIIY RTFSIFVLAC ILLYLGRAPV PFFTKKLNDE
     LQFNKSGFLW LNKPWPTFFF DYYRWNRPFR YIENNRFTNK SPVKKSVSQY FFNISLSDGK
     QKISFTALPS LSIFEKDLKT YLNISTNNNN LYKNWLDTKN ERKDNLLYEL ENRIQALDNG
     LVIKEVIEKK TSLSNNEGIN LTKINDPFLN GSFRGKAIIT KSPWLLKENS YKLKKNRKIV
     YLKENKLKIW ISNRWRELRR KNLPLPWEPL NKNARRSLVL LIQGSKNKKL KRKLQQIHFS
     EEQALINLTK QTNISDLTEK LENKHLLNKK FTKISHFNWE LVLNLSPRQR AVYFKELEYE
     KWQILVRSWK NLLSVNSINS TQLNKFILLL KKLFTFHKKF ALQEISKELP RWTSKLRNDK
     FDVIAIGITD IRQRKVKNLG YLIKGKEKRR KIVRRFSQQS DFRRRLVKGS MRSRRRKTLI
     WKILQLKTHS PFFLRINEKH IPFQISLNKL NLIDVKHIFK NPVEKQKKIA LFPTKNNVTL
     KKKTKADRLA IANRWDFPLA QWGRSWLLLI QSYFRKYLIL PILIISKNII RLLLFQTPEW
     SEDWNDWNKE MYIKCTYDGI EVSEKALPEQ WLRDGLQIKI IYPFILKPWH NLQLETNIKK
     NLNDLMNTND NFSTNIKKKK IKYSYLTAWG FETNAPFGDI KKKPSFWKPI RKELKKKWKK
     NILLNFNKIY SKFSLVKKKI TNNSNNSINN ESKDLVKENI KINNNLKFNL TNKNYNKKLP
     EQISSKFSQT ILSENQIKNK YKISTNIQKL ENLKFLKKSK IEKITKKINF DKIEFFNKLN
     NDNKVYFTNK QKKIENKQKL IKYYKKNISL VNKWSYFFKL NFNKINKNFF QFSINIIRFN
     INLISKIQQN LILIKNRKIW NPLKVSQINQ KKDKINYKYS NDFGEKIQSL KINVNQENIL
     LMSQAYLFHK IWQIEKTNNK CDFKYLLKNW TSNSVIKKKI NRNLKKMDLK FLKEQNWKNW
     LQNFNKYNLS SQVWYKLAPQ KWRNQINYQW KGKEQNNLKF SEKQIKALTL SKEKTFFYKL
     FIDSLLEQNR KISKRYKYNY LCYSYLDFKK QPNFLESTKN KKESLFNNEI LQISKNQVNN
     NYKQDISLKS NLILWLIPTL TEKKYINKIE TINRNNISLL KEKNKKNSRN KKTLRERERH
     ETIRQWKWKS KNIEKRFKEL GDMASLMTFM QDQENSVSLS AKMRENLDLF RLLFCRDVGV
     NKLTINSEHR LPRVLDDQIL MYKVISLFLK SKNRFKKNVN ITNFNLSTSR IEFFQNNNQN
     NNFNLINLED IMLLKHRKEL KVLNLLNLKQ NTNQILNFNK VILKENKRKR IELNKIQNKN
     QNLTIKHFLW PTFRLEDLAC VNRFWFNTSN GSRFTMLRIR MYT