ID   TI214_RANMC             Reviewed;        1788 AA.
AC   A1XGT3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Protein TIC 214 {ECO:0000250|UniProtKB:P56785};
DE   AltName: Full=Translocon at the inner envelope membrane of chloroplasts 214 {ECO:0000250|UniProtKB:P56785};
DE            Short=AtTIC214 {ECO:0000250|UniProtKB:P56785};
GN   Name=TIC214 {ECO:0000250|UniProtKB:P56785}; Synonyms=ycf1;
OS   Ranunculus macranthus (Large buttercup).
OG   Plastid; Chloroplast.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Ranunculales; Ranunculaceae; Ranunculoideae;
OC   Ranunculeae; Ranunculus.
OX   NCBI_TaxID=334596;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17573971; DOI=10.1186/1471-2164-8-174;
RA   Raubeson L.A., Peery R., Chumley T.W., Dziubek C., Fourcade H.M.,
RA   Boore J.L., Jansen R.K.;
RT   "Comparative chloroplast genomics: analyses including new sequences from
RT   the angiosperms Nuphar advena and Ranunculus macranthus.";
RL   BMC Genomics 8:174-174(2007).
CC   -!- FUNCTION: Involved in protein precursor import into chloroplasts. May
CC       be part of an intermediate translocation complex acting as a protein-
CC       conducting channel at the inner envelope.
CC       {ECO:0000250|UniProtKB:P56785}.
CC   -!- SUBUNIT: Part of the Tic complex. {ECO:0000250|UniProtKB:P56785}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC       {ECO:0000250|UniProtKB:P56785}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TIC214 family. {ECO:0000305}.
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DR   EMBL; DQ359689; ABC70801.2; -; Genomic_DNA.
DR   RefSeq; YP_001004231.2; NC_008796.1.
DR   AlphaFoldDB; A1XGT3; -.
DR   PRIDE; A1XGT3; -.
DR   GeneID; 4712183; -.
DR   GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR008896; TIC214.
DR   PANTHER; PTHR33163; PTHR33163; 2.
DR   Pfam; PF05758; Ycf1; 2.
PE   3: Inferred from homology;
KW   Chloroplast; Membrane; Plastid; Plastid inner membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1788
FT                   /note="Protein TIC 214"
FT                   /id="PRO_0000326586"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          248..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1482..1526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        248..282
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1492..1514
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1788 AA;  213429 MW;  7D28BE073D5FFCFE CRC64;
     MNINNYSITL ILLIKSNLVS SCMKIINSVV VVGLYYGFFT TFSIGPSYFF LLRARVLEVG
     DEKEISATTI GFIAGQLMMF ISIYYAPLHL ALRKPHTITA LVLPYLLFHF FWNNHKNFFD
     SVYTTGNSMR NLNIQCIFLN SLIFQLFNHF ILPSSTLARL INIYMFRYNN KMLFVASSFV
     GWLVGHIFFM KWVELVLFWI RQNHLIRSNK YLVSELKNSM SRIFSILLFI VCIYYLGRMP
     SPLVTKKLKK TSKREERGKN KEETDVEIEK ISEEKGTNEQ QEGSAEEDPS LCSEEKEGLD
     KIDETEEIQV NLNGREKTKD EFNKEKYSKN SPVCENYDLD GNQDNFELKK KEKEKKNIFW
     FEKPLVTLLF DYKRWNRPLR YIKNDFFENA VRNEMSQYFF YTCQSDGKQK ISFTYLPSLS
     TFLEMIQQKM LLCITEKRSY EESYNNWVYT NDEKKKNLSN ELFNRIAVLD KGFLVTDVLE
     KRTRLCNYEN EQECLPKIYD PLLNGPYRGT IKELYSRSSM NEYLIPSIED PRDTIWINKL
     YDIFPTDFKE LKKKKIGKRI NEIKKKVFQW SYKLIDDLEE EEEEEETTED RGIRSRKAKR
     VVIFNDNETT KNNASNRDQV DEVALISYSQ QSDFRRDIIK GSMRAQRRKT VTWKLFQTRV
     HSPLFLDRID KIFVLSFDID RILNFIFRNW MVEVTEFKIM DSEEQKAKKK DKKKKENERI
     TIAETWDTVL FAQTIRGCIL VIQSILRKLI VLPSLIIAKN IGHMLVFKPT EWHEDFEELN
     KEIHVKCTYN GVQLSENEFP KNWLTDGIQI KILFPFCLKS RHRSKLQPED SLKKKGKKQN
     FYFLTVWGME AELPFGSPRK GPSFFETIWK QLKKKHKKVK VKSFVAVKII KERTKWFGKV
     SNEKTKWVTK KVQFIKKIMK ELTKRNSISL FELKKVSESN SNRNKTEKFS IISNKMIPEF
     AIRIRSIDWT NYSLTEKKMK DMADRINTIR NQIEKITKDK KSIFLTTTTD RNIRPNKTSW
     DDKRLEQSKI FWQIVKRGRA KIIRKCNFFF HFCIEKICID IFLSIINIPS RNIQILFQQK
     KKINDKYSYN DETKKNPIHF ISTIKRSIYK TTNTSNKSQI LCDLSFLSQA YVFYKLSQIQ
     VSNKYNLKSL FQYHGTIPFI KDKIKIFFGT QGIFNSESRH KNFHDFGMNE WQSWLMGNDQ
     YQYNLSQTCW SGLVPQKWRN RINKNLANSS NFYFYEKEPL IHYEKEKNYA VNSLPSRREK
     LKNYKYDLLS NKYINYENNS SSSFYGLPLE VNQAHAILYN YNTYNSEVFD LSGDIDFRNY
     LREDYDIDRD QNSDRKYLDW RTFNFCLRKK RNIAEWTNID IGTSTTITKK IKSQIHYYQI
     IDKLEKNKTD NKGFLNLAIY KQIDSANQTK VFFDWMGMNE EILNWSILNR ELWFFPEFLL
     LYDAYKIQPW IIPLNLLLLK LNINEKQKGD LHISYNKNKS LDLENRNQEE TQQPVRGDLG
     SYVQKENNPG SDPLKKQTDG KEDFDRSNIQ RNINKKKSKS NIAAELDFFL KKYFLFQLRW
     DNSFSEKIIN NIKIYCLLLR LKNPKEIAIS SIQRDEMSMD VMLVPKATTF IKLRKRRLLL
     IEPARLSINW DGLFIMYQTL VILQVHNSKY QTCKKKINVD NKGLIESMAR HEILFRNRDK
     NNYDFLIPEN LLSSRRRREL RIQICLNLRN FKVGDRNREF SNENSTRSCD LFFYEDKNLD
     VDIKKILKFK FFLWPNYRLE DLACMNRYWF DTNNGSRFSM SRIHMYPY