ID   BRZ_HALS3               Reviewed;          60 AA.
AC   B0R5N8;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Transcriptional regulator Brz;
DE   AltName: Full=Bacteriorhodopsin-regulating zinc finger protein;
GN   Name=brz; OrderedLocusNames=OE_3104F;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF CYS-11 AND HIS-52.
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18179416; DOI=10.1111/j.1365-2958.2007.06081.x;
RA   Tarasov V.Y., Besir H., Schwaiger R., Klee K., Furtwangler K., Pfeiffer F.,
RA   Oesterhelt D.;
RT   "A small protein from the bop-brp intergenic region of Halobacterium
RT   salinarum contains a zinc finger motif and regulates bop and crtB1
RT   transcription.";
RL   Mol. Microbiol. 67:772-780(2008).
CC   -!- FUNCTION: Activates transcription of bacteriorhodopsin (bop) and
CC       phytoene synthase (crtB1). May interact with DNA or RNA via the zinc
CC       finger motif. {ECO:0000269|PubMed:18179416}.
CC   -!- DISRUPTION PHENOTYPE: Mutants show various up-regulated and down-
CC       regulated genes, including bop and crtB1.
CC       {ECO:0000269|PubMed:18179416}.
CC   -!- SIMILARITY: Belongs to the Brz family. {ECO:0000305}.
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DR   EMBL; AM774415; CAP14055.1; -; Genomic_DNA.
DR   RefSeq; WP_012289336.1; NC_010364.1.
DR   AlphaFoldDB; B0R5N8; -.
DR   EnsemblBacteria; CAP14055; CAP14055; OE_3104F.
DR   GeneID; 5953593; -.
DR   GeneID; 62886915; -.
DR   KEGG; hsl:OE_3104F; -.
DR   HOGENOM; CLU_209475_0_0_2; -.
DR   OMA; NGHECYV; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Activator; Metal-binding; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..60
FT                   /note="Transcriptional regulator Brz"
FT                   /id="PRO_0000411893"
FT   ZN_FING         8..52
FT                   /note="C4-type; atypical"
FT                   /evidence="ECO:0000255"
FT   MUTAGEN         11
FT                   /note="C->S: Loss of activity."
FT                   /evidence="ECO:0000269|PubMed:18179416"
FT   MUTAGEN         52
FT                   /note="H->F: Loss of activity."
FT                   /evidence="ECO:0000269|PubMed:18179416"
SQ   SEQUENCE   60 AA;  6798 MW;  C24F9B5132B2EE39 CRC64;
     MPITDLHCPR CGSDVKMGLP MGATVKSVTA ASRQEPTSDT QKVRTVECRN DHEFFVRFEW