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TI231_ARATH
ID   TI231_ARATH             Reviewed;         187 AA.
AC   Q9LNQ1; Q9ARG3;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit TIM23-1;
GN   Name=TIM23-1; OrderedLocusNames=At1g17530; ORFNames=F11A6.4, F1L3.24;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Urban M., Braun H.P.;
RT   "Arabidopsis thaliana translocase of inner mitochondrial membrane homolog
RT   (TIM23).";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=12692332; DOI=10.1104/pp.102.016808;
RA   Murcha M.W., Lister R., Ho A.Y., Whelan J.;
RT   "Identification, expression, and import of components 17 and 23 of the
RT   inner mitochondrial membrane translocase from Arabidopsis.";
RL   Plant Physiol. 131:1737-1747(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [6]
RP   TISSUE SPECIFICITY.
RX   PubMed=14730085; DOI=10.1104/pp.103.033910;
RA   Lister R., Chew O., Lee M.N., Heazlewood J.L., Clifton R., Parker K.L.,
RA   Millar A.H., Whelan J.;
RT   "A transcriptomic and proteomic characterization of the Arabidopsis
RT   mitochondrial protein import apparatus and its response to mitochondrial
RT   dysfunction.";
RL   Plant Physiol. 134:777-789(2004).
RN   [7]
RP   SUBCELLULAR LOCATION.
RX   PubMed=17098851; DOI=10.1104/pp.106.090688;
RA   Murcha M.W., Elhafez D., Lister R., Tonti-Filippini J., Baumgartner M.,
RA   Philippar K., Carrie C., Mokranjac D., Soll J., Whelan J.;
RT   "Characterization of the preprotein and amino acid transporter gene family
RT   in Arabidopsis.";
RL   Plant Physiol. 143:199-212(2007).
CC   -!- FUNCTION: Essential component of the TIM17:23 complex, a complex that
CC       mediates the translocation of transit peptide-containing proteins
CC       across the mitochondrial inner membrane. Links the inner and outer
CC       membranes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the TIM17:23 complex at least composed of TIM23,
CC       TIM17 and TIM50. The complex interacts with the TIM44 component of the
CC       PAM complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, flowers, cotyledons and leaves.
CC       {ECO:0000269|PubMed:12692332, ECO:0000269|PubMed:14730085}.
CC   -!- DEVELOPMENTAL STAGE: Peak of expression during cotyledon development.
CC       {ECO:0000269|PubMed:12692332}.
CC   -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR   EMBL; AY029217; AAK31587.1; -; mRNA.
DR   EMBL; AY463972; AAR26373.1; -; mRNA.
DR   EMBL; AC022492; AAF79468.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE29602.1; -; Genomic_DNA.
DR   EMBL; AY045586; AAK73944.1; -; mRNA.
DR   EMBL; AY093787; AAM10403.1; -; mRNA.
DR   RefSeq; NP_564028.1; NM_101615.4.
DR   AlphaFoldDB; Q9LNQ1; -.
DR   SMR; Q9LNQ1; -.
DR   STRING; 3702.AT1G17530.1; -.
DR   TCDB; 3.A.8.1.3; the mitochondrial protein translocase (mpt) family.
DR   iPTMnet; Q9LNQ1; -.
DR   PaxDb; Q9LNQ1; -.
DR   PRIDE; Q9LNQ1; -.
DR   ProteomicsDB; 246424; -.
DR   EnsemblPlants; AT1G17530.1; AT1G17530.1; AT1G17530.
DR   GeneID; 838327; -.
DR   Gramene; AT1G17530.1; AT1G17530.1; AT1G17530.
DR   KEGG; ath:AT1G17530; -.
DR   Araport; AT1G17530; -.
DR   TAIR; locus:2007893; AT1G17530.
DR   eggNOG; KOG3324; Eukaryota.
DR   HOGENOM; CLU_118311_0_0_1; -.
DR   InParanoid; Q9LNQ1; -.
DR   OrthoDB; 1418527at2759; -.
DR   PhylomeDB; Q9LNQ1; -.
DR   PRO; PR:Q9LNQ1; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9LNQ1; baseline and differential.
DR   Genevisible; Q9LNQ1; AT.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IDA:TAIR.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015450; F:protein-transporting ATPase activity; TAS:TAIR.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0006626; P:protein targeting to mitochondrion; TAS:TAIR.
DR   InterPro; IPR045238; Tim23-like.
DR   PANTHER; PTHR15371; PTHR15371; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..187
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit TIM23-1"
FT                   /id="PRO_0000420938"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        169
FT                   /note="I -> S (in Ref. 1; AAK31587)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   187 AA;  19974 MW;  C67A0180A49F5677 CRC64;
     MAINRSSDHE SDENTRLYHP YQNYQVPIKS QYLYKLPTSP EFLFTEESLK QRRSWGENLT
     FYTGTGYLAG SVAGASAGIF SGIKSFENGD TTKLKINRIL NSSGQAGRTW GNRVGIVGLI
     YAGIESGVVA VTDKDDVWTS VVAGLGTGAV FRAARGVRSA AVAGAFGGIA AGAVVAGKQV
     FKRYAHI
 
 
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