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TI23B_HUMAN
ID   TI23B_HUMAN             Reviewed;         188 AA.
AC   Q5SRD1; B4DDK6; E7EP42; Q5SRD2;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-AUG-2020, sequence version 3.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit Tim23B {ECO:0000305};
DE            Short=TIMM23B {ECO:0000305};
GN   Name=TIMM23B {ECO:0000312|HGNC:HGNC:23581};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   CHARACTERIZATION, AND ALTERNATIVE SPLICING.
RX   PubMed=29413900; DOI=10.1016/j.bbagrm.2018.01.006;
RA   Prieto-Ruiz J.A., Alis R., Garcia-Benlloch S., Saez-Atienzar S.,
RA   Ventura I., Hernandez-Andreu J.M., Hernandez-Yago J., Blesa J.R.;
RT   "Expression of the human TIMM23 and TIMM23B genes is regulated by the GABP
RT   transcription factor.";
RL   Biochim. Biophys. Acta 1861:80-94(2018).
CC   -!- FUNCTION: May participate in the translocation of transit peptide-
CC       containing proteins across the mitochondrial inner membrane. the PAM
CC       complex (By similarity). {ECO:0000250|UniProtKB:O14925}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5SRD1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5SRD1-2; Sequence=VSP_060625;
CC   -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR   EMBL; AL672187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL442003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK293228; BAG56767.1; -; mRNA.
DR   EMBL; FO393433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FP565721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS73131.1; -. [Q5SRD1-1]
DR   CCDS; CCDS76301.1; -. [Q5SRD1-2]
DR   RefSeq; NP_001277046.1; NM_001290117.1. [Q5SRD1-1]
DR   RefSeq; NP_001277047.1; NM_001290118.1. [Q5SRD1-2]
DR   RefSeq; XP_016870949.1; XM_017015460.1.
DR   AlphaFoldDB; Q5SRD1; -.
DR   IntAct; Q5SRD1; 18.
DR   MINT; Q5SRD1; -.
DR   iPTMnet; Q5SRD1; -.
DR   PhosphoSitePlus; Q5SRD1; -.
DR   SwissPalm; Q5SRD1; -.
DR   BioMuta; TIMM23B; -.
DR   EPD; Q5SRD1; -.
DR   jPOST; Q5SRD1; -.
DR   MassIVE; Q5SRD1; -.
DR   MaxQB; Q5SRD1; -.
DR   PaxDb; Q5SRD1; -.
DR   PeptideAtlas; Q5SRD1; -.
DR   PRIDE; Q5SRD1; -.
DR   ProteomicsDB; 17280; -.
DR   ProteomicsDB; 63842; -.
DR   Antibodypedia; 27714; 8 antibodies from 4 providers.
DR   DNASU; 100652748; -.
DR   Ensembl; ENST00000651259.3; ENSP00000502369.1; ENSG00000204152.14. [Q5SRD1-1]
DR   Ensembl; ENST00000652716.1; ENSP00000502146.1; ENSG00000204152.14. [Q5SRD1-2]
DR   GeneID; 100652748; -.
DR   KEGG; hsa:100652748; -.
DR   MANE-Select; ENST00000651259.3; ENSP00000502369.1; NM_001290117.2; NP_001277046.1.
DR   UCSC; uc031wgt.2; human. [Q5SRD1-1]
DR   CTD; 100652748; -.
DR   GeneCards; TIMM23B; -.
DR   HGNC; HGNC:23581; TIMM23B.
DR   HPA; ENSG00000204152; Low tissue specificity.
DR   neXtProt; NX_Q5SRD1; -.
DR   OpenTargets; ENSG00000178440; -.
DR   OpenTargets; ENSG00000204152; -.
DR   VEuPathDB; HostDB:ENSG00000204152; -.
DR   GeneTree; ENSGT00390000001094; -.
DR   GeneTree; ENSGT00940000154453; -.
DR   HOGENOM; CLU_063935_2_0_1; -.
DR   InParanoid; Q5SRD1; -.
DR   OMA; KYRQYNP; -.
DR   OrthoDB; 1418527at2759; -.
DR   PhylomeDB; Q5SRD1; -.
DR   TreeFam; TF106196; -.
DR   PathwayCommons; Q5SRD1; -.
DR   SignaLink; Q5SRD1; -.
DR   BioGRID-ORCS; 100652748; 15 hits in 148 CRISPR screens.
DR   ChiTaRS; TIMM23B; human.
DR   GenomeRNAi; 100652748; -.
DR   Pharos; Q5SRD1; Tdark.
DR   PRO; PR:Q5SRD1; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q5SRD1; protein.
DR   Bgee; ENSG00000204152; Expressed in tibialis anterior and 179 other tissues.
DR   ExpressionAtlas; Q5SRD1; baseline and differential.
DR   Genevisible; Q5SRD1; HS.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   InterPro; IPR005681; Tim23.
DR   InterPro; IPR045238; Tim23-like.
DR   PANTHER; PTHR15371; PTHR15371; 1.
DR   TIGRFAMs; TIGR00983; 3a0801s02tim23; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..188
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit Tim23B"
FT                   /id="PRO_0000349114"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         87..134
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_060625"
SQ   SEQUENCE   188 AA;  19670 MW;  21F8DBB6B4A32C15 CRC64;
     MEGGGGSGDK TTGVLAGFFG AGEAGYSHAD LAGVPLTGMN PLCPYLNVDP RYLVQDTDEF
     ILPTGANKTW GRFELAFFTI GGCCMTGAAF GAMNGLRLGL KETQNMAWSK PGNVQILNMV
     TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDLNTVAA GTMTGMLYKC TVSEMALDSP
     FCVLLSGS
 
 
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