TIAF1_HUMAN
ID TIAF1_HUMAN Reviewed; 115 AA.
AC O95411; A2RRE2; Q6PEG2;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Putative TGFB1-induced anti-apoptotic factor 1 {ECO:0000305};
DE AltName: Full=12 kDa TGF-beta-1-induced antiapoptotic factor;
GN Name=MYO18A; Synonyms=TIAF1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC TISSUE=Mammary gland;
RX PubMed=9918798; DOI=10.1006/bbrc.1998.9846;
RA Chang N.-S., Mattison J., Cao H., Pratt N., Zhao Y., Lee C.;
RT "Cloning and characterization of a novel transforming growth factor-beta1-
RT induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity.";
RL Biochem. Biophys. Res. Commun. 253:743-749(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=12829915; DOI=10.1097/01.tp.0000069829.71088.88;
RA van der Leij J., van den Berg A., Albrecht E.W., Blokzijl T.,
RA Roozendaal R., Gouw A.S., de Jong K.P., Stegeman C.A., van Goor H.,
RA Chang N.S., Poppema S.;
RT "High expression of TIAF-1 in chronic kidney and liver allograft rejection
RT and in activated T-helper cells.";
RL Transplantation 75:2076-2082(2003).
CC -!- FUNCTION: [Isoform TIAF1]: Inhibits the cytotoxic effects of TNF-alpha
CC and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1.
CC Involved in TGF-beta1 inhibition of IkappaB-alpha expression and
CC suppression of TNF-mediated IkappaB-alpha degradation.
CC {ECO:0000269|PubMed:9918798}.
CC -!- INTERACTION:
CC O95411; PRO_0000000092 [P05067]: APP; NbExp=3; IntAct=EBI-302378, EBI-821758;
CC O95411; P54253: ATXN1; NbExp=3; IntAct=EBI-302378, EBI-930964;
CC O95411; Q8WUI4-6: HDAC7; NbExp=3; IntAct=EBI-302378, EBI-12094670;
CC -!- SUBCELLULAR LOCATION: [Isoform TIAF1]: Nucleus
CC {ECO:0000269|PubMed:9918798}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=TIAF1 {ECO:0000303|PubMed:9918798};
CC IsoId=O95411-1; Sequence=Displayed;
CC Name=1; Synonyms=Alpha, SP-R210L;
CC IsoId=Q92614-1; Sequence=External;
CC Name=2; Synonyms=Beta;
CC IsoId=Q92614-2; Sequence=External;
CC Name=3;
CC IsoId=Q92614-3; Sequence=External;
CC Name=4;
CC IsoId=Q92614-4; Sequence=External;
CC Name=5; Synonyms=SP-R210S;
CC IsoId=Q92614-5; Sequence=External;
CC -!- TISSUE SPECIFICITY: Not detectable in normal kidney and liver. Up-
CC regulated in chronic and acute allograft rejection: expressed in the
CC inflammatory infiltrate and in tubular epithelial cells.
CC {ECO:0000269|PubMed:12829915}.
CC -!- CAUTION: Product of a dubious CDS prediction. The TIAF1 protein is
CC coded in the 3'-UTR region of MYO18A. Does not seem to exist in
CC orthologs. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF105277; AAD04172.1; -; mRNA.
DR EMBL; AC024619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471159; EAW51180.1; -; Genomic_DNA.
DR EMBL; BC047669; AAH47669.1; -; mRNA.
DR EMBL; BC058075; AAH58075.1; -; mRNA.
DR EMBL; BC131561; AAI31562.1; -; mRNA.
DR RefSeq; NP_004731.2; NM_004740.3.
DR AlphaFoldDB; O95411; -.
DR BioGRID; 114653; 8.
DR IntAct; O95411; 6.
DR STRING; 9606.ENSP00000352424; -.
DR BioMuta; TIAF1; -.
DR PaxDb; O95411; -.
DR PRIDE; O95411; -.
DR Antibodypedia; 26652; 112 antibodies from 28 providers.
DR DNASU; 9220; -.
DR GeneID; 9220; -.
DR UCSC; uc002hdv.2; human. [O95411-1]
DR DisGeNET; 9220; -.
DR GeneCards; TIAF1; -.
DR HGNC; HGNC:31104; MYO18A.
DR HPA; ENSG00000221995; Tissue enhanced (brain).
DR MIM; 609517; gene.
DR neXtProt; NX_O95411; -.
DR OpenTargets; ENSG00000221995; -.
DR PharmGKB; PA36512; -.
DR VEuPathDB; HostDB:ENSG00000221995; -.
DR eggNOG; ENOG502TD57; Eukaryota.
DR GeneTree; ENSGT00650000095071; -.
DR HOGENOM; CLU_2108251_0_0_1; -.
DR InParanoid; O95411; -.
DR OMA; QFRADPS; -.
DR OrthoDB; 34123at2759; -.
DR PathwayCommons; O95411; -.
DR SignaLink; O95411; -.
DR BioGRID-ORCS; 9220; 20 hits in 1031 CRISPR screens.
DR GeneWiki; TIAF1; -.
DR GenomeRNAi; 9220; -.
DR Pharos; O95411; Tbio.
DR PRO; PR:O95411; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; O95411; protein.
DR Bgee; ENSG00000221995; Expressed in apex of heart and 95 other tissues.
DR Genevisible; O95411; HS.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IDA:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
PE 5: Uncertain;
KW Alternative splicing; Apoptosis; Nucleus; Reference proteome.
FT CHAIN 1..115
FT /note="Putative TGFB1-induced anti-apoptotic factor 1"
FT /id="PRO_0000072534"
FT CONFLICT 49
FT /note="A -> V (in Ref. 1; AAD04172)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 115 AA; 12414 MW; C71C03671CBDB3B9 CRC64;
MSSPSSPFRE QSFLCAAGDA GEESRVQVLK NEVRRGSPVL LGWVEQAYAD KCVCGPSAPP
APTPPSLSQR VMCNDLFKVN PFQLQQFRAD PSTASLLLCP GGLDHKLNLR GKAWG
