TIC22_ARATH
ID TIC22_ARATH Reviewed; 268 AA.
AC Q9SZB2; F4JIW4;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Protein TIC 22, chloroplastic;
DE AltName: Full=Translocon at the inner envelope membrane of chloroplasts 22;
DE Short=AtTIC22;
DE Flags: Precursor;
GN Name=TIC22; Synonyms=TIC22-IV; OrderedLocusNames=At4g33350;
GN ORFNames=F17M5.110;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP INTERACTION WITH OEP61.
RX PubMed=21612577; DOI=10.1042/bj20110448;
RA von Loeffelholz O., Kriechbaumer V., Ewan R.A., Jonczyk R., Lehmann S.,
RA Young J.C., Abell B.M.;
RT "OEP61 is a chaperone receptor at the plastid outer envelope.";
RL Biochem. J. 438:143-153(2011).
RN [6]
RP REVIEW.
RX PubMed=20100520; DOI=10.1016/j.bbamcr.2010.01.015;
RA Kovacs-Bogdan E., Soll J., Bolter B.;
RT "Protein import into chloroplasts: the Tic complex and its regulation.";
RL Biochim. Biophys. Acta 1803:740-747(2010).
CC -!- FUNCTION: Involved in protein precursor import into chloroplasts.
CC Imported into the intermembrane space via the Toc translocon. May be
CC involved in the import pathway used by proteins without a cleavable N-
CC terminal pre-sequence (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the Tic complex (By similarity). Interacts with OEP61
CC during its transport into the intermembrane space. {ECO:0000250,
CC ECO:0000269|PubMed:21612577}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast intermembrane space
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9SZB2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9SZB2-2; Sequence=VSP_041953;
CC -!- SIMILARITY: Belongs to the Tic22 family. {ECO:0000305}.
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DR EMBL; AL035678; CAB38793.1; -; Genomic_DNA.
DR EMBL; AL161583; CAB80052.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86209.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86210.1; -; Genomic_DNA.
DR EMBL; AK118805; BAC43395.1; -; mRNA.
DR EMBL; BT005417; AAO63837.1; -; mRNA.
DR PIR; T05986; T05986.
DR RefSeq; NP_001190901.1; NM_001203972.1. [Q9SZB2-2]
DR RefSeq; NP_195061.1; NM_119489.4. [Q9SZB2-1]
DR AlphaFoldDB; Q9SZB2; -.
DR SMR; Q9SZB2; -.
DR BioGRID; 14755; 11.
DR IntAct; Q9SZB2; 10.
DR STRING; 3702.AT4G33350.1; -.
DR iPTMnet; Q9SZB2; -.
DR PaxDb; Q9SZB2; -.
DR PRIDE; Q9SZB2; -.
DR ProteomicsDB; 234428; -. [Q9SZB2-1]
DR EnsemblPlants; AT4G33350.1; AT4G33350.1; AT4G33350. [Q9SZB2-1]
DR EnsemblPlants; AT4G33350.2; AT4G33350.2; AT4G33350. [Q9SZB2-2]
DR GeneID; 829471; -.
DR Gramene; AT4G33350.1; AT4G33350.1; AT4G33350. [Q9SZB2-1]
DR Gramene; AT4G33350.2; AT4G33350.2; AT4G33350. [Q9SZB2-2]
DR KEGG; ath:AT4G33350; -.
DR Araport; AT4G33350; -.
DR TAIR; locus:2119146; AT4G33350.
DR eggNOG; ENOG502QPNF; Eukaryota.
DR InParanoid; Q9SZB2; -.
DR OMA; HIQDVVK; -.
DR PhylomeDB; Q9SZB2; -.
DR PRO; PR:Q9SZB2; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SZB2; baseline and differential.
DR Genevisible; Q9SZB2; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0009941; C:chloroplast envelope; HDA:TAIR.
DR GO; GO:0031972; C:chloroplast intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR005692; Tic22.
DR InterPro; IPR007378; Tic22-like.
DR PANTHER; PTHR33926; PTHR33926; 1.
DR Pfam; PF04278; Tic22; 1.
DR TIGRFAMs; TIGR00995; 3a0901s06TIC22; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chloroplast; Membrane; Plastid; Protein transport;
KW Reference proteome; Transit peptide; Transport.
FT TRANSIT 1..59
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 60..268
FT /note="Protein TIC 22, chloroplastic"
FT /id="PRO_0000413670"
FT VAR_SEQ 201..226
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_041953"
SQ SEQUENCE 268 AA; 30105 MW; F2CCA862E2D4B43A CRC64;
MESSVKPNPF LSFSSFIHHQ CTRFSSDLSA RIEDTKRFAE TLATRRFSLP TPPPFASVSQ
SKSGTPTTTL SPSLVAKALA GTSVFTVSNT NNEFVLISDP TGGKSIGLLC FRQEDAEAFL
AQARLRRREL KTNAKVVPIT LDQVYLLKVE GISFRFLPDP IQIKNALELK SSGNKNGFDG
VPVFQSELLV VRKKNRRYCP VYFSKEDIER ELSKYTRASR GDQQIMVGSL EDVLRKMEMS
EKNSGWEDVI FIPPGRSYAQ HMQDLIKE
