TIC62_ORYSJ
ID TIC62_ORYSJ Reviewed; 497 AA.
AC Q10A77;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein TIC 62, chloroplastic;
DE AltName: Full=Translocon at the inner envelope membrane of chloroplasts 62;
DE Short=OsTIC62;
DE Flags: Precursor;
GN Name=TIC62;
GN OrderedLocusNames=LOC_Os10g01044 {ECO:0000312|EMBL:ABG65881.1},
GN Os10g0100300 {ECO:0000312|EMBL:BAF25922.1};
GN ORFNames=OSNPB_100100300 {ECO:0000312|EMBL:BAT09555.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12791992; DOI=10.1126/science.1083523;
RA Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S.,
RA Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D.,
RA Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M.,
RA Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F.,
RA Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M.,
RA Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R.,
RA Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F.,
RA Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D.,
RA Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R.,
RA Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S.,
RA Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S.,
RA Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R.,
RA Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M.,
RA Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R.,
RA Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E.,
RA Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.;
RT "In-depth view of structure, activity, and evolution of rice chromosome
RT 10.";
RL Science 300:1566-1569(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP INTERACTION WITH LFNR1 AND LFNR2.
RC STRAIN=cv. Nipponbare;
RX PubMed=26941088; DOI=10.1105/tpc.15.01027;
RA Yang C., Hu H., Ren H., Kong Y., Lin H., Guo J., Wang L., He Y., Ding X.,
RA Grabsztunowicz M., Mulo P., Chen T., Liu Y., Wu Z., Wu Y., Mao C., Wu P.,
RA Mo X.;
RT "LIGHT-INDUCED RICE1 regulates light-dependent attachment of LEAF-TYPE
RT FERREDOXIN-NADP+ OXIDOREDUCTASE to the thylakoid membrane in rice and
RT Arabidopsis.";
RL Plant Cell 28:712-728(2016).
CC -!- FUNCTION: Involved in protein precursor import into chloroplasts. Part
CC of the redox regulon consisting of TIC32, TIC 55 and TIC62. Acts as a
CC membrane anchor of LFNR1 and LFNR2. Has a NADPH-dependent dehydrogenase
CC activity, but only after preincubation with lipids.
CC {ECO:0000250|UniProtKB:Q8H0U5}.
CC -!- SUBUNIT: Part of the Tic complex. Interacts with TIC110 and TIC55 (By
CC similarity). Interacts with LFNR1 and LFNR2. Component of high
CC molecular weight thylakoid LFNRs-containing protein complexes
CC containing LIR1, LFNR1, LFNR2, TIC62 and TROL proteins
CC (PubMed:26941088). {ECO:0000250|UniProtKB:Q8H0U5,
CC ECO:0000269|PubMed:26941088}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC {ECO:0000250|UniProtKB:Q8H0U5}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q8H0U5}. Plastid, chloroplast stroma
CC {ECO:0000250|UniProtKB:Q8H0U5}. Plastid, chloroplast thylakoid
CC {ECO:0000250|UniProtKB:Q8H0U5}. Note=Shuttles between the membranes and
CC the stroma, depending on the redox state of the plastidic NADP(+)/NADPH
CC pool. {ECO:0000250|UniProtKB:Q8H0U5}.
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DR EMBL; DP000086; ABG65881.1; -; Genomic_DNA.
DR EMBL; AP008216; BAF25922.1; -; Genomic_DNA.
DR EMBL; AP014966; BAT09555.1; -; Genomic_DNA.
DR EMBL; AK065110; BAG89364.1; -; mRNA.
DR RefSeq; XP_015612840.1; XM_015757354.1.
DR AlphaFoldDB; Q10A77; -.
DR SMR; Q10A77; -.
DR STRING; 4530.OS10T0100300-01; -.
DR PaxDb; Q10A77; -.
DR PRIDE; Q10A77; -.
DR EnsemblPlants; Os10t0100300-01; Os10t0100300-01; Os10g0100300.
DR GeneID; 4347935; -.
DR Gramene; Os10t0100300-01; Os10t0100300-01; Os10g0100300.
DR KEGG; osa:4347935; -.
DR eggNOG; KOG1203; Eukaryota.
DR HOGENOM; CLU_025711_7_1_1; -.
DR InParanoid; Q10A77; -.
DR OMA; KLKIVEC; -.
DR OrthoDB; 1166292at2759; -.
DR Proteomes; UP000000763; Chromosome 10.
DR Proteomes; UP000059680; Chromosome 10.
DR GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009570; C:chloroplast stroma; IEA:UniProtKB-SubCell.
DR GO; GO:0098807; C:chloroplast thylakoid membrane protein complex; IDA:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR044719; TIC62.
DR PANTHER; PTHR47285; PTHR47285; 2.
DR Pfam; PF13460; NAD_binding_10; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Chloroplast; Membrane; NAD; NADP; Plastid; Plastid inner membrane;
KW Protein transport; Reference proteome; Repeat; Thylakoid; Transit peptide;
KW Transport.
FT TRANSIT 1..55
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 56..497
FT /note="Protein TIC 62, chloroplastic"
FT /evidence="ECO:0000255"
FT /id="PRO_0000442381"
FT REPEAT 346..367
FT /note="1"
FT /evidence="ECO:0000250|UniProtKB:Q8H0U5"
FT REPEAT 408..429
FT /note="2"
FT /evidence="ECO:0000250|UniProtKB:Q8H0U5"
FT REPEAT 474..495
FT /note="3"
FT /evidence="ECO:0000250|UniProtKB:Q8H0U5"
FT REGION 310..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..495
FT /note="3 X 22 AA approximate repeats"
FT /evidence="ECO:0000250|UniProtKB:Q8H0U5"
FT COMPBIAS 335..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 75..104
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000255"
SQ SEQUENCE 497 AA; 52202 MW; 4565C28F0B611660 CRC64;
MEQAAKATIS LSPPSYAGCC MAACPYRSTR HLRRGGGCSA RSISSLRHAP SARVYAAAAA
AATPESKSTK ENDLVFIAGA TGKVGSRAVR EFIKLGFRVR AGVRSAQRAS SLVQSVEQLK
VDDDATSPAE RLEIVECDLE KQAQSDIVSA IGNAAIVVCS IGASEKDILD VTGPYRIDYM
ATNNLVQAAT AAKVEHFILV TSLGTNRIGF PAFLLNLFWG VLCWKRRAEE ALIGSGLPYT
IVRPGGMERP TDAFKETHNL VVAVEDTYVG GLVSNLQVAE LIACIASNRR TAYCKVVEAI
AETTAPLLPT EDQLANIPSK RQPPPEPEVV QQGETPPKPI QQSQRPLSPY TAFVDLKPPS
SPSPCPPSAA APAPTSTDTA AAGSSSTLNS SATGTPISVD QPKQQQRPLS PYTRYEELKP
PSSPSPTPPS AASSASVSAS PDTPPAAAAS SAALDSSANG TPITGDQLNQ QQSPLSPYTR
YEELKPPSSP TPSTPKL
