TICRR_DANRE
ID TICRR_DANRE Reviewed; 1824 AA.
AC Q6DRL4;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Treslin;
DE AltName: Full=TopBP1-interacting checkpoint and replication regulator;
DE AltName: Full=TopBP1-interacting, replication-stimulating protein;
GN Name=ticrr;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA Hopkins N.;
RT "Identification of 315 genes essential for early zebrafish development.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20080954; DOI=10.1101/gad.1860310;
RA Sansam C.L., Cruz N.M., Danielian P.S., Amsterdam A., Lau M.L., Hopkins N.,
RA Lees J.A.;
RT "A vertebrate gene, ticrr, is an essential checkpoint and replication
RT regulator.";
RL Genes Dev. 24:183-194(2010).
CC -!- FUNCTION: Regulator of DNA replication and S/M and G2/M checkpoints.
CC Regulates the triggering of DNA replication initiation via its
CC interaction with topbp1 by participating in cdk2-mediated loading of
CC cdc45l onto replication origins. Required for the transition from pre-
CC replication complex (pre-RC) to pre-initiation complex (pre-IC).
CC Required to prevent mitotic entry after treatment with ionizing
CC radiation. {ECO:0000269|PubMed:20080954}.
CC -!- SUBUNIT: Interacts with topbp1 (via BRCT domains); interaction takes
CC place in a cdk2-dependent manner (By similarity). Component of the
CC replisome complex (By similarity). {ECO:0000250,
CC ECO:0000250|UniProtKB:Q7Z2Z1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Associates with
CC chromatin.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality, due to impaired S-phase
CC progression and disruption of the S/M checkpoint, leading to premature
CC mitotic entry and mitotic catastrophe. {ECO:0000269|PubMed:20080954}.
CC -!- SIMILARITY: Belongs to the treslin family. {ECO:0000305}.
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DR EMBL; AY648745; AAT68063.1; -; mRNA.
DR RefSeq; NP_001003887.1; NM_001003887.1.
DR AlphaFoldDB; Q6DRL4; -.
DR PaxDb; Q6DRL4; -.
DR PRIDE; Q6DRL4; -.
DR GeneID; 445411; -.
DR KEGG; dre:445411; -.
DR CTD; 90381; -.
DR ZFIN; ZDB-GENE-040728-1; ticrr.
DR InParanoid; Q6DRL4; -.
DR OrthoDB; 150355at2759; -.
DR PhylomeDB; Q6DRL4; -.
DR PRO; PR:Q6DRL4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0006281; P:DNA repair; IMP:UniProtKB.
DR GO; GO:0006260; P:DNA replication; IMP:UniProtKB.
DR GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IMP:UniProtKB.
DR GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IMP:UniProtKB.
DR GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; ISS:UniProtKB.
DR GO; GO:0010212; P:response to ionizing radiation; IMP:UniProtKB.
DR InterPro; IPR026153; Treslin.
DR InterPro; IPR032746; Treslin_N.
DR PANTHER; PTHR21556; PTHR21556; 1.
DR Pfam; PF15292; Treslin_N; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; DNA damage; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..1824
FT /note="Treslin"
FT /id="PRO_0000391874"
FT REGION 542..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1189..1221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1293..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1459..1518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1617..1650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1803..1824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..947
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1293..1379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1459..1478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1479..1493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1617..1646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1824 AA; 201945 MW; 517DB5C1368D83F5 CRC64;
MASQNVVFAI DVDYRPEGTQ NTTNAYQDHL KQWILRVLLS LGHRYGLEKV RWGYKFFNSR
TVKSATLITR GSDFKELQEK VFSDFEEELH VKFTTEGKSP RSQEKSHKLK PSPACCVQNA
LKEILLDFQW DRPDLTSPTK VTLRPRRSSR SGRNIPLQDC DMLSVDKNVL FVVSECPRSK
AELEDYLSMR REDSRHHKDI NEQMLPKGLI DMLMQRNVVL HWADSGVFKA DHVAKDYTGI
ETLMERLGLV GGQVVPMLSP CLPLMDQHPK MNSLLALGVD AFPIDSTNSY LHLSKRMQQQ
LFPPLGASFS WIADGTKRSC NVTLEPVSYR QRSLRAPVDV LLKGVLQSLD ILSLSHSAIE
TWILQCPDAE LGQEAFQHLK QLSTGGHAML AEVSEGDVVC SAVLSVLSSC TAQITVLQPL
LAQEGQLLPA DLVSLDTTDI SGDLPDVVSS VLSVMYDIME EDDCSDHEKM PLVPDWANQE
LKQQSSSRSN GMVEGWFPLS DQSGISCHLM ESMRLLHAAP EEKEKGEEYS DTQQEITSSL
SEFYQSSTAG SSGSLRSKKR GTQCTPVRQK MKTMSRSLQM LNFARLNVKA QKTQGDSGSA
GSGKGTEKGG KKSSGDRTKP GLLHFSSEEE LLSHLGLTYQ KAVENRTMSV PSQVQDLLSV
VKSFLKSNTE ASLLNLVQKH VLKSCQSIRQ HYGNSSDDES KIRECQLQAV LRLELCKQTE
QEDEEVVEQR VEDVADMLRN ISRSKDAVYL SRFMQEEVLP LYMNSIPKVL ADVYHSLGTQ
LPEALVAVLP SDFFSDESLA KDSVSVSLSS FSATQSNISS VGDHLEELRN RSAKKRRQSM
ITRHKSMTEA PQALRQIEMP RKSTRLAKPK LCVPIEKTAV EQPPLPKQPV QEVTKVRRNL
FNQVTVSPSK KSKMPRSQSV SAVEGIKKRK RSDVDNDDRH TLLTKKVSET PLHKQVSSRL
LHRQRTGRKS GESDVCIIEE SPIKPAADLR RSPRIKSLTR RHSSVFYSSS QPRSRNLDRV
VSSSQLSHSE GKGKFSVSSV RSPVRLLFGA TQSPGRLRHT TVSSLEDQAS KGLPLRCSSF
ENQNKTPQKL RSDALASAVG CRTPQSPRTP NRTVGDNGMA LRGSPFQSPA AKSIVVETPM
KSPLKGILKT PIKKSLLDCV SPNGAWLRSP GCKTPKKCVT WSPSPRKPVP ENQVNVPDSP
VFAKRHSPRL VTPGKNSSPE EKIVFKTPDK VPQRKSKTSP EIILRRLEIP VNIDPETCKS
ITRSGKIRTL SLPYKTSKGS DEFLPQSESG SFPFCNSPLK PNIQKTIQSP IPTHRMCTRS
GNTPVKESCS PSSNSQGITG TSPSPRKSLS SAVAKSSPSP SFGPSRSGVG NQNNSSISNV
EKHTDDDKII VQNKANDEKA EEASSSDSQQ FDCSEFSITT DDESIDISEA AVVKTQLVGG
IKMNIAFSRK PSKSDVFEFE GKQTTSTGTP LTRSYGFRQT PDRRQREAEA RLGYSSGKPK
ISTPRTRRTP ACGKQSSPQP LTYEVEMEMQ ASGLPKLKLR RTDSFNAGDL PSSATKGMTS
HLVHRNKTNL KAPQIDSPLV QSSRHPGCIS PSLCSRATPA KGTPGKGVQT YICQSITPTH
HPTSSQSPLA SPLTPSPQSR GWPTPENLNS WPRKKRARIE TCGNKEQVIK GVPLLEKTGV
IEDPELEGIF RIQGVEELKE SLSTPISQRK LGLRSSQVMD HQGSPEGMDW TETMAQMCDA
KDSTKTEQFA WMGRKVDTPK VKKQVSASGI FALTQSPLLY KKSAVIKEAT QFSGSKSELE
ISPLCQPRRR RTPSRTYSRK KLLD
