TIC_ARATH
ID TIC_ARATH Reviewed; 1550 AA.
AC Q94KE2; Q94C89; Q9LUW1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Protein TIME FOR COFFEE;
GN Name=TIC; OrderedLocusNames=At3g22380; ORFNames=MCB17.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION.
RX PubMed=14555691; DOI=10.1105/tpc.013730;
RA Hall A., Bastow R.M., Davis S.J., Hanano S., McWatters H.G., Hibberd V.,
RA Doyle M.R., Sung S., Halliday K.J., Amasino R.M., Millar A.J.;
RT "The TIME FOR COFFEE gene maintains the amplitude and timing of Arabidopsis
RT circadian clocks.";
RL Plant Cell 15:2719-2729(2003).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, AND SUBCELLULAR
RP LOCATION.
RX PubMed=17496120; DOI=10.1105/tpc.106.047241;
RA Ding Z., Millar A.J., Davis A.M., Davis S.J.;
RT "TIME FOR COFFEE encodes a nuclear regulator in the Arabidopsis thaliana
RT circadian clock.";
RL Plant Cell 19:1522-1536(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [7]
RP FUNCTION, AND INTERACTION WITH MYC2.
RX PubMed=22693280; DOI=10.1105/tpc.111.095430;
RA Shin J., Heidrich K., Sanchez-Villarreal A., Parker J.E., Davis S.J.;
RT "TIME FOR COFFEE represses accumulation of the MYC2 transcription factor to
RT provide time-of-day regulation of jasmonate signaling in Arabidopsis.";
RL Plant Cell 24:2470-2482(2012).
CC -!- FUNCTION: Regulator of normal clock function. Acts in the mid to late
CC night. Contributes to the amplitude of circadian clocks. May act on the
CC transcriptional induction of LATE ELONGATED HYPOCOTYL (LHY). Inhibits
CC MYC2 protein accumulation, acting as a negative factor in the JA-
CC signaling pathway. {ECO:0000269|PubMed:14555691,
CC ECO:0000269|PubMed:17496120, ECO:0000269|PubMed:22693280}.
CC -!- SUBUNIT: Interacts with MYC2. {ECO:0000269|PubMed:22693280}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17496120}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q94KE2-1; Sequence=Displayed;
CC -!- DEVELOPMENTAL STAGE: Constitutively expressed over circadian time (at
CC protein level). Not autoregulated. {ECO:0000269|PubMed:17496120}.
CC -!- DISRUPTION PHENOTYPE: Plants have a reduced amplitude and accuracy of
CC circadian rhythms. {ECO:0000269|PubMed:17496120}.
CC -!- MISCELLANEOUS: Called 'TIME FOR COFFEE' because it acts in the mid to
CC late night, a phase at which any human activity often requires coffee.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK56246.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB01776.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB022215; BAB01776.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE76628.1; -; Genomic_DNA.
DR EMBL; AF367257; AAK56246.1; ALT_FRAME; mRNA.
DR EMBL; AY035062; AAK59567.2; -; mRNA.
DR RefSeq; NP_566705.1; NM_113136.4. [Q94KE2-1]
DR AlphaFoldDB; Q94KE2; -.
DR BioGRID; 7139; 9.
DR STRING; 3702.AT3G22380.2; -.
DR iPTMnet; Q94KE2; -.
DR PaxDb; Q94KE2; -.
DR ProteomicsDB; 234279; -. [Q94KE2-1]
DR EnsemblPlants; AT3G22380.1; AT3G22380.1; AT3G22380. [Q94KE2-1]
DR GeneID; 821807; -.
DR Gramene; AT3G22380.1; AT3G22380.1; AT3G22380. [Q94KE2-1]
DR KEGG; ath:AT3G22380; -.
DR Araport; AT3G22380; -.
DR eggNOG; ENOG502QTJH; Eukaryota.
DR HOGENOM; CLU_002205_0_0_1; -.
DR InParanoid; Q94KE2; -.
DR PhylomeDB; Q94KE2; -.
DR PRO; PR:Q94KE2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q94KE2; baseline and differential.
DR Genevisible; Q94KE2; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042752; P:regulation of circadian rhythm; IBA:GO_Central.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR InterPro; IPR039317; TIC.
DR PANTHER; PTHR34798; PTHR34798; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Biological rhythms; Nucleus; Reference proteome.
FT CHAIN 1..1550
FT /note="Protein TIME FOR COFFEE"
FT /id="PRO_0000326473"
FT REGION 1..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1321..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..119
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..168
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1550 AA; 164456 MW; DB6A73BD21A89A92 CRC64;
MDRNREARRV PMAAAGNGLS RRRHRAGSFR DSPEEEGPVE LPEAARLRDR GGSNKKDRDR
ERDRDRERER ERDRERDRLN SRSKRRRGER LMMVHGNLDD GGDDSSEESV NDDEEYDDGG
VGPPSSLKML PPTSNNISAA SFSSSLSNHH NGGSGNLHHH HHSHNNNHQR KNNFPPTKVF
RSSPSPAPVS PLVSTWKAAD EMIGVSVPRK ARSACTKRPH ESWASSTTGG GVFASGEQIH
RQISSTSPAN RVSPASILAS PSPPAPTSPS SSSISVRKKL PSGTKQKPLP PKSSSSKLSS
PVAVQDEIEI EIAEVLYGMM RMPSTSKQEA AGNDLTEAAK STVEVKSRVS SPISNPQTLP
QSSITLAANS SSSNVSAIAP KRKKPRHVKY EDDNSSRVTT IKSEAEAPSK SQVPFSNQLK
SSGSGEGNSS VLDSIIPLTR ESNASLDSEK KENNLSKDET ILPKVESSSG FRSDGEGAKS
SSPEKEKFEI DLMAPPPVRS SSERGGEMME CVAAEAKPKV TEVETEAKPL LKEDRSDPAI
HDSQEKKRPR MVAEAEHHKF ERNCELKLDL DKSDHVGLVN KHHVQKPPPQ QQLSVPDKTA
QASHLPLHMS MPGWPGGLPT MGYMAPTQGV VPTDTSSLSA AAMQPPPHLL FNQPRPKRCA
THCYIARNIQ SHQQFTKMNP FWPAAAGSAP MYGTKACNLS LMPPTELQGS VLGRSSNPVQ
DKNSQSTSKS SETAQRNQLM LQQALPPGAA NSILHGPTFI FPLGQQPHAA ATIAAASVRP
PNSGITSSGP TATSTSMNGS ASATPAGAPT MSFSYPAMPG NETQYLAILQ NNGYPFPVPA
HVGAQPAYRG APGQPMPFFN GSFYSSQMIQ PPHHQPQKQH QQQLTGQMLQ SHAPNNQNGS
ASTGSSAAQK HLQNQQLRPP INHGNSQGFP THKVQSQPLN FQQRQQPREN ATQHSETVGE
DSPSTADSRG SRSNVAYGQN YGMQMQPTNL GLMSSPAPGG GVVGSSSSHG EKKSQQQVSK
AGVESFQSPG YAMTFATFNG ANTAPTLNMS SIAQNHAMFH SMPEAARQGY QMMAAQAAQQ
KMNYGASLED GKSGSIGGAA TANNTPEEQR KSGGGAIGKT SGGNGGQSIA FSNKQDLADA
SVSAVTSGSI VDSSSRLLNL GSALPQSSGS LPTSHHQQLL QQQQQQHMQR SQSQQPYTTM
YLQKQQRYAT SVAASAARTK GPVVSNGSGF PDHNMTTSPA GTTKFANANS GFPQNLVQSS
SNQVQSQQWK NNSPRTTNTT QAQSPSMLSP STSVAAASSL RNIPHKQQSR PQQSQISFAA
NSKPMTSGSP MQQVQGGTNH QAPSPPMLVG SPSTSSVSKN ASGSPRTTAS ASSAANKGGQ
ASTTTHSASQ PSKNLQPASA ASSAGGRNNG PSVLGNPTTS SGSKSQQQQQ LPKHGLQPQA
QLFFSNPYMQ AQHQHQQQQI TISPSGGYYI QRHQQQSGSA PAVPVTGAVT ATSDPAKAIA
AASAANNMKG GGGMGKTQQH QLGPPGFTNV HAVSSAVQVK PVDQKQQAGE
