TIDC1_MOUSE
ID TIDC1_MOUSE Reviewed; 285 AA.
AC Q8BUY5; Q99LS9; Q9CSI1;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Complex I assembly factor TIMMDC1, mitochondrial {ECO:0000305};
DE AltName: Full=Translocase of inner mitochondrial membrane domain-containing protein 1;
DE Short=TIMM domain containing-protein 1;
GN Name=Timmdc1 {ECO:0000312|MGI:MGI:1922139};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Chaperone protein involved in the assembly of the
CC mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
CC Participates in constructing the membrane arm of complex I (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with the intermediate 315 kDa subcomplex of
CC incompletely assembled complex I. Interacts with TMEM70 (By
CC similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9NPL8}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR EMBL; AK012774; BAB28461.1; -; mRNA.
DR EMBL; AK081781; BAC38330.1; -; mRNA.
DR EMBL; BC002243; AAH02243.1; -; mRNA.
DR CCDS; CCDS28169.1; -.
DR RefSeq; NP_077235.2; NM_024273.2.
DR AlphaFoldDB; Q8BUY5; -.
DR BioGRID; 218392; 4.
DR IntAct; Q8BUY5; 1.
DR STRING; 10090.ENSMUSP00000002925; -.
DR iPTMnet; Q8BUY5; -.
DR PhosphoSitePlus; Q8BUY5; -.
DR EPD; Q8BUY5; -.
DR MaxQB; Q8BUY5; -.
DR PaxDb; Q8BUY5; -.
DR PeptideAtlas; Q8BUY5; -.
DR PRIDE; Q8BUY5; -.
DR ProteomicsDB; 258883; -.
DR Antibodypedia; 53806; 39 antibodies from 15 providers.
DR DNASU; 76916; -.
DR Ensembl; ENSMUST00000002925; ENSMUSP00000002925; ENSMUSG00000002846.
DR GeneID; 76916; -.
DR KEGG; mmu:76916; -.
DR UCSC; uc012afp.1; mouse.
DR CTD; 51300; -.
DR MGI; MGI:1922139; Timmdc1.
DR VEuPathDB; HostDB:ENSMUSG00000002846; -.
DR eggNOG; KOG4608; Eukaryota.
DR GeneTree; ENSGT00390000013817; -.
DR HOGENOM; CLU_068982_0_0_1; -.
DR InParanoid; Q8BUY5; -.
DR OMA; WQYKWRL; -.
DR OrthoDB; 1366254at2759; -.
DR PhylomeDB; Q8BUY5; -.
DR TreeFam; TF324676; -.
DR Reactome; R-MMU-6799198; Complex I biogenesis.
DR BioGRID-ORCS; 76916; 18 hits in 70 CRISPR screens.
DR ChiTaRS; Timmdc1; mouse.
DR PRO; PR:Q8BUY5; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8BUY5; protein.
DR Bgee; ENSMUSG00000002846; Expressed in gastrula and 194 other tissues.
DR Genevisible; Q8BUY5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
PE 1: Evidence at protein level;
KW Chaperone; Membrane; Mitochondrion; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..285
FT /note="Complex I assembly factor TIMMDC1, mitochondrial"
FT /id="PRO_0000252479"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 265..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 277
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NPL8"
FT CONFLICT 26
FT /note="G -> E (in Ref. 2; AAH02243)"
FT /evidence="ECO:0000305"
FT CONFLICT 261..262
FT /note="GD -> EN (in Ref. 2; AAH02243)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="H -> D (in Ref. 2; AAH02243)"
FT /evidence="ECO:0000305"
FT CONFLICT 285
FT /note="H -> D (in Ref. 2; AAH02243)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 285 AA; 31791 MW; F4E1FB023769B158 CRC64;
MGAPPPAPRS RLCGAWGPFP RVFAAGAVAA DSPGFVEDRE QRSGVSDPGS LESGWDRLRQ
LFAKDEQQRF SKEIDYIYRA AVSAGIIGWA YGGIPAFIYA KKRYIEQSQA EIYHNRFDAV
QSAHRAATRG FIRYGWRWSW RTAVFVTIFN TVNTGLTVYR NKDAMSHFAI AGAVTGGLFR
INLGVRGLVA GSIIGALLGA PMGSLLMALE KYSGETVQER RQKEWKALHE QRLEEWRSSL
QVTELLPMEI ESGLEKIQPE GDAQRIEELL SLPRNPSSPH QQSKH
