ID   TIDC1_RAT               Reviewed;         285 AA.
AC   Q6AY94;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Complex I assembly factor TIMMDC1, mitochondrial {ECO:0000305};
DE   AltName: Full=Translocase of inner mitochondrial membrane domain-containing protein 1;
DE            Short=TIMM domain containing-protein 1;
GN   Name=Timmdc1 {ECO:0000312|RGD:1359380};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Chaperone protein involved in the assembly of the
CC       mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
CC       Participates in constructing the membrane arm of complex I (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the intermediate 315 kDa subcomplex of
CC       incompletely assembled complex I. Interacts with TMEM70 (By
CC       similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9NPL8}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR   EMBL; BC079140; AAH79140.1; -; mRNA.
DR   RefSeq; NP_001007677.1; NM_001007676.1.
DR   AlphaFoldDB; Q6AY94; -.
DR   STRING; 10116.ENSRNOP00000004023; -.
DR   PaxDb; Q6AY94; -.
DR   PRIDE; Q6AY94; -.
DR   GeneID; 303922; -.
DR   KEGG; rno:303922; -.
DR   UCSC; RGD:1359380; rat.
DR   CTD; 51300; -.
DR   RGD; 1359380; Timmdc1.
DR   VEuPathDB; HostDB:ENSRNOG00000002999; -.
DR   eggNOG; KOG4608; Eukaryota.
DR   HOGENOM; CLU_068982_0_0_1; -.
DR   InParanoid; Q6AY94; -.
DR   OMA; WQYKWRL; -.
DR   OrthoDB; 1366254at2759; -.
DR   PhylomeDB; Q6AY94; -.
DR   TreeFam; TF324676; -.
DR   Reactome; R-RNO-6799198; Complex I biogenesis.
DR   PRO; PR:Q6AY94; -.
DR   Proteomes; UP000002494; Chromosome 11.
DR   Bgee; ENSRNOG00000002999; Expressed in skeletal muscle tissue and 20 other tissues.
DR   Genevisible; Q6AY94; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
PE   2: Evidence at transcript level;
KW   Chaperone; Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..285
FT                   /note="Complex I assembly factor TIMMDC1, mitochondrial"
FT                   /id="PRO_0000252480"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   285 AA;  32050 MW;  37AFB5BA93994B97 CRC64;
     MEAPPPAPRS RLCGAWGPFP RVFAAGAVAA DSQSFVEDPE LRSYVSDPGS SESGWDRLRQ
     LFVKDEQRKI SKEMDYICRA ALSAGIIGWA YGGIPAFIYA KRRYIEQSQA EIYHNRFDAV
     QSAHRAATRG FIRYGWRWSW RTAVFVTIFN TVNTGLTVYR NKDALSHFAI AGAVTGGLFR
     INLGLRGLVA GGIIGALLGT PMGSLLMALE KHCGETVQER RQKDREAQQE QRLEEWRRNL
     QVTELLPMEI ESGLEKIQPE KDAQRIEELL RLPRNPASPD KQSED