ID   TIE1_DANRE              Reviewed;         184 AA.
AC   O73792;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Tyrosine-protein kinase receptor Tie-1;
DE            EC=2.7.10.1;
DE   Flags: Fragment;
GN   Name=tie1; Synonyms=tie-1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Embryo;
RX   PubMed=9603430;
RX   DOI=10.1002/(sici)1097-0177(199805)212:1<133::aid-aja12>3.0.co;2-8;
RA   Lyons M.S., Bell B., Stainier D., Peters K.G.;
RT   "Isolation of the zebrafish homologues for the tie-1 and tie-2 endothelium-
RT   specific receptor tyrosine kinases.";
RL   Dev. Dyn. 212:133-140(1998).
CC   -!- FUNCTION: Transmembrane tyrosine-protein kinase that may modulate
CC       TEK/TIE2 activity and contribute to the regulation of angiogenesis.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in most populations of endothelial cells
CC       in 24 hours embryos, including the endocardium.
CC       {ECO:0000269|PubMed:9603430}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Tie subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR   EMBL; AF053633; AAC09332.1; -; mRNA.
DR   AlphaFoldDB; O73792; -.
DR   SMR; O73792; -.
DR   STRING; 7955.ENSDARP00000016803; -.
DR   PaxDb; O73792; -.
DR   ZFIN; ZDB-GENE-990415-55; tie1.
DR   eggNOG; KOG0200; Eukaryota.
DR   InParanoid; O73792; -.
DR   PhylomeDB; O73792; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0001568; P:blood vessel development; IMP:ZFIN.
DR   GO; GO:0071603; P:endothelial cell-cell adhesion; IMP:ZFIN.
DR   GO; GO:0007507; P:heart development; IGI:ZFIN.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IBA:GO_Central.
DR   GO; GO:0033674; P:positive regulation of kinase activity; IBA:GO_Central.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   GO; GO:0001944; P:vasculature development; IMP:ZFIN.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   2: Evidence at transcript level;
KW   Angiogenesis; ATP-binding; Cell membrane; Kinase; Membrane;
KW   Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome;
KW   Transferase; Transmembrane; Tyrosine-protein kinase.
FT   CHAIN           <1..184
FT                   /note="Tyrosine-protein kinase receptor Tie-1"
FT                   /id="PRO_0000088172"
FT   DOMAIN          <1..164
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        25
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10028"
FT   MOD_RES         53
FT                   /note="Phosphotyrosine; by autocatalysis"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   184 AA;  21190 MW;  38F6A35FFC1DB7F8 CRC64;
     QLLQFAADVA TGMHYLSDKQ FIHRDLAARN VLVGDNLVAK IADFGLSRGE EVYVKKTMGR
     LPVRWMAIES LNYSVYTTKS DVWSFGVLLW EIVSLGGTPY CGMTCAELYE KLPQGYRMEQ
     PRNCDDEVYE LMRQCWRDRP YERPPFSQIS VQLNRMQEAR KAYVNMALFE NFTYAGIDAT
     AEEA