TIF3A_ARATH
ID TIF3A_ARATH Reviewed; 238 AA.
AC Q9M246;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein TIFY 3A;
DE AltName: Full=Jasmonate ZIM domain-containing protein 11;
GN Name=TIFY3A; Synonyms=JAZ11; OrderedLocusNames=At3g43440;
GN ORFNames=T18D12.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17637675; DOI=10.1038/nature06006;
RA Chini A., Fonseca S., Fernandez G., Adie B., Chico J.M., Lorenzo O.,
RA Garcia-Casado G., Lopez-Vidriero I., Lozano F.M., Ponce M.R., Micol J.L.,
RA Solano R.;
RT "The JAZ family of repressors is the missing link in jasmonate
RT signalling.";
RL Nature 448:666-671(2007).
RN [5]
RP DOMAIN.
RX PubMed=17675405; DOI=10.1105/tpc.107.050708;
RA Yan Y., Stolz S., Chetelat A., Reymond P., Pagni M., Dubugnon L.,
RA Farmer E.E.;
RT "A downstream mediator in the growth repression limb of the jasmonate
RT pathway.";
RL Plant Cell 19:2470-2483(2007).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17499004; DOI=10.1016/j.tplants.2007.04.004;
RA Vanholme B., Grunewald W., Bateman A., Kohchi T., Gheysen G.;
RT "The tify family previously known as ZIM.";
RL Trends Plant Sci. 12:239-244(2007).
RN [7]
RP INDUCTION BY WOUNDING AND HERBIVORY.
RX PubMed=18223147; DOI=10.1104/pp.107.115691;
RA Chung H.S., Koo A.J., Gao X., Jayanty S., Thines B., Jones A.D., Howe G.A.;
RT "Regulation and function of Arabidopsis JASMONATE ZIM-domain genes in
RT response to wounding and herbivory.";
RL Plant Physiol. 146:952-964(2008).
RN [8]
RP FUNCTION, AND INTERACTION WITH TIFY10A/JAZ1; TIFY10B/JAZ2; TIFY6B/JAZ3;
RP TIFY6A/JAZ4; TIFY7/JAZ9 AND TIFY9/JAZ10.
RX PubMed=19151223; DOI=10.1105/tpc.108.064097;
RA Chung H.S., Howe G.A.;
RT "A critical role for the TIFY motif in repression of jasmonate signaling by
RT a stabilized splice variant of the JASMONATE ZIM-domain protein JAZ10 in
RT Arabidopsis.";
RL Plant Cell 21:131-145(2009).
RN [9]
RP INTERACTION WITH MYC2.
RX PubMed=19309455; DOI=10.1111/j.1365-313x.2009.03852.x;
RA Chini A., Fonseca S., Chico J.M., Fernandez-Calvo P., Solano R.;
RT "The ZIM domain mediates homo- and heteromeric interactions between
RT Arabidopsis JAZ proteins.";
RL Plant J. 59:77-87(2009).
RN [10]
RP INTERACTION WITH AFPH2/NINJA.
RX PubMed=20360743; DOI=10.1038/nature08854;
RA Pauwels L., Barbero G.F., Geerinck J., Tilleman S., Grunewald W.,
RA Perez A.C., Chico J.M., Bossche R.V., Sewell J., Gil E., Garcia-Casado G.,
RA Witters E., Inze D., Long J.A., De Jaeger G., Solano R., Goossens A.;
RT "NINJA connects the co-repressor TOPLESS to jasmonate signalling.";
RL Nature 464:788-791(2010).
RN [11]
RP FUNCTION, INTERACTION WITH MYC2 AND MYC4, AND SUBUNIT.
RX PubMed=21335373; DOI=10.1105/tpc.110.080788;
RA Fernandez-Calvo P., Chini A., Fernandez-Barbero G., Chico J.M.,
RA Gimenez-Ibanez S., Geerinck J., Eeckhout D., Schweizer F., Godoy M.,
RA Franco-Zorrilla J.M., Pauwels L., Witters E., Puga M.I., Paz-Ares J.,
RA Goossens A., Reymond P., De Jaeger G., Solano R.;
RT "The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of
RT JAZ repressors and act additively with MYC2 in the activation of jasmonate
RT responses.";
RL Plant Cell 23:701-715(2011).
RN [12]
RP INTERACTION WITH MYB21 AND MYB24.
RX PubMed=21447791; DOI=10.1105/tpc.111.083089;
RA Song S., Qi T., Huang H., Ren Q., Wu D., Chang C., Peng W., Liu Y.,
RA Peng J., Xie D.;
RT "The Jasmonate-ZIM domain proteins interact with the R2R3-MYB transcription
RT factors MYB21 and MYB24 to affect Jasmonate-regulated stamen development in
RT Arabidopsis.";
RL Plant Cell 23:1000-1013(2011).
CC -!- FUNCTION: Repressor of jasmonate (JA) responses. Targets MYC2, MYC3 and
CC MYC4 that are JA-dependent transcription activators.
CC {ECO:0000269|PubMed:19151223, ECO:0000269|PubMed:21335373}.
CC -!- SUBUNIT: Interacts with MYC2, MYB21, MYB24, AFPH2/NINJA, TIFY10A/JAZ1,
CC TIFY10B/JAZ2, TIFY6B/JAZ3, TIFY6A/JAZ4, TIFY7/JAZ9 and TIFY9/JAZ10.
CC {ECO:0000269|PubMed:19151223, ECO:0000269|PubMed:19309455,
CC ECO:0000269|PubMed:20360743, ECO:0000269|PubMed:21335373,
CC ECO:0000269|PubMed:21447791}.
CC -!- INTERACTION:
CC Q9M246; Q9LNJ5: BHLH13; NbExp=5; IntAct=EBI-2312209, EBI-4434261;
CC Q9M246; Q39204: MYC2; NbExp=5; IntAct=EBI-2312209, EBI-1792336;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9M246-1; Sequence=Displayed;
CC -!- INDUCTION: Up-regulated by wounding and herbivory.
CC {ECO:0000269|PubMed:18223147}.
CC -!- DOMAIN: The jas domains (101-120) and (197-222) are required for
CC interaction with COI1. {ECO:0000250|UniProtKB:Q7XPM8}.
CC -!- PTM: Ubiquitinated. Targeted for degradation by the SCF(COI1) E3
CC ubiquitin ligase-proteasome pathway during jasmonate signaling.
CC {ECO:0000250|UniProtKB:Q7XPM8}.
CC -!- SIMILARITY: Belongs to the TIFY/JAZ family. {ECO:0000305}.
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DR EMBL; AL138644; CAB81784.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77795.1; -; Genomic_DNA.
DR EMBL; BT015154; AAT85750.1; -; mRNA.
DR EMBL; BT015661; AAU15160.1; -; mRNA.
DR PIR; T47386; T47386.
DR RefSeq; NP_189930.1; NM_114212.5. [Q9M246-1]
DR AlphaFoldDB; Q9M246; -.
DR SMR; Q9M246; -.
DR BioGRID; 8748; 22.
DR DIP; DIP-53278N; -.
DR IntAct; Q9M246; 10.
DR STRING; 3702.AT3G43440.1; -.
DR iPTMnet; Q9M246; -.
DR PaxDb; Q9M246; -.
DR PRIDE; Q9M246; -.
DR ProteomicsDB; 234353; -. [Q9M246-1]
DR DNASU; 823426; -.
DR EnsemblPlants; AT3G43440.1; AT3G43440.1; AT3G43440. [Q9M246-1]
DR GeneID; 823426; -.
DR Gramene; AT3G43440.1; AT3G43440.1; AT3G43440. [Q9M246-1]
DR KEGG; ath:AT3G43440; -.
DR Araport; AT3G43440; -.
DR TAIR; locus:2098179; AT3G43440.
DR HOGENOM; CLU_088770_2_0_1; -.
DR InParanoid; Q9M246; -.
DR OrthoDB; 1501574at2759; -.
DR PhylomeDB; Q9M246; -.
DR PRO; PR:Q9M246; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M246; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0031347; P:regulation of defense response; IBA:GO_Central.
DR GO; GO:2000022; P:regulation of jasmonic acid mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0009611; P:response to wounding; IBA:GO_Central.
DR InterPro; IPR018467; CCT_CS.
DR InterPro; IPR040390; TIFY/JAZ.
DR InterPro; IPR010399; Tify_dom.
DR PANTHER; PTHR33077; PTHR33077; 2.
DR Pfam; PF09425; Jas_motif; 2.
DR Pfam; PF06200; tify; 2.
DR SMART; SM00979; TIFY; 2.
DR PROSITE; PS51320; TIFY; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Jasmonic acid signaling pathway; Nucleus;
KW Plant defense; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..238
FT /note="Protein TIFY 3A"
FT /id="PRO_0000300641"
FT DOMAIN 39..74
FT /note="Tify 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00650"
FT DOMAIN 125..160
FT /note="Tify 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00650"
FT REGION 219..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 101..120
FT /note="Jas 1"
FT /evidence="ECO:0000255"
FT MOTIF 103..110
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOTIF 197..222
FT /note="Jas 2"
FT /evidence="ECO:0000255"
FT MOTIF 199..206
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
SQ SEQUENCE 238 AA; 25841 MW; 841F602E9BE9EE9E CRC64;
MAEVNGDFPV PSFADGTGSV SAGLDLLVER SIHEARSTEP DASTQLTIIF GGSCRVFNGV
PAQKVQEIIR IAFAGKQTKN VTGINPALNR ALSFSTVADL PIARRRSLQR FLEKRRDRST
KPDGSMILPS QLTIIFGGSF SVFDGIPAEK VQEILHIAAA AKATETINLT SINPALKRAI
SFSNASTVAC VSTADVPIAR RRSLQRFFEK RRHRFVHTKP YSATTSEADK NETSPIVT
