TIF4B_ARATH
ID TIF4B_ARATH Reviewed; 315 AA.
AC Q8GY55; O23328;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein TIFY 4B;
DE AltName: Full=Protein PEAPOD 2;
GN Name=TIFY4B; Synonyms=PPD2; OrderedLocusNames=At4g14720;
GN ORFNames=dl3400c, FCAALL.297;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
RX PubMed=16916932; DOI=10.1073/pnas.0604349103;
RA White D.W.R.;
RT "PEAPOD regulates lamina size and curvature in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:13238-13243(2006).
RN [6]
RP INTERACTION WITH AFPH2/NINJA.
RX PubMed=20360743; DOI=10.1038/nature08854;
RA Pauwels L., Barbero G.F., Geerinck J., Tilleman S., Grunewald W.,
RA Perez A.C., Chico J.M., Bossche R.V., Sewell J., Gil E., Garcia-Casado G.,
RA Witters E., Inze D., Long J.A., De Jaeger G., Solano R., Goossens A.;
RT "NINJA connects the co-repressor TOPLESS to jasmonate signalling.";
RL Nature 464:788-791(2010).
CC -!- FUNCTION: Regulates the arrest of dispersed meristematic cells during
CC lamina development. {ECO:0000269|PubMed:16916932}.
CC -!- SUBUNIT: Interacts with AFPH2/NINJA. {ECO:0000269|PubMed:20360743}.
CC -!- INTERACTION:
CC Q8GY55; Q9S7Z2: AFP4; NbExp=3; IntAct=EBI-15206004, EBI-1778843;
CC Q8GY55; Q9SV55: AFPH2; NbExp=7; IntAct=EBI-15206004, EBI-1787005;
CC Q8GY55; Q9ZNV8: AHP2; NbExp=3; IntAct=EBI-15206004, EBI-1100687;
CC Q8GY55; Q9LNW3: AIP1; NbExp=3; IntAct=EBI-15206004, EBI-1573499;
CC Q8GY55; Q84JY3: At4g32295; NbExp=3; IntAct=EBI-15206004, EBI-4425069;
CC Q8GY55; F4JL11: IMPA2; NbExp=3; IntAct=EBI-15206004, EBI-1253508;
CC Q8GY55; Q8LCG7: NFYC2; NbExp=3; IntAct=EBI-15206004, EBI-2125983;
CC Q8GY55; Q9FMV5: NFYC4; NbExp=3; IntAct=EBI-15206004, EBI-2466018;
CC Q8GY55; Q8L4B2: NFYC9; NbExp=3; IntAct=EBI-15206004, EBI-2466050;
CC Q8GY55; Q9S7H5: SCL21; NbExp=4; IntAct=EBI-15206004, EBI-1238472;
CC Q8GY55; Q7XA73: TIFY4A; NbExp=3; IntAct=EBI-15206004, EBI-15199673;
CC Q8GY55; Q9LVI4: TIFY6B; NbExp=3; IntAct=EBI-15206004, EBI-1792431;
CC Q8GY55; Q84MB2: TIFY8; NbExp=3; IntAct=EBI-15206004, EBI-4426557;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
CC -!- DEVELOPMENTAL STAGE: First detected at the tip of developing leaf,
CC followed by a tip-to-base progression of the expression.
CC {ECO:0000269|PubMed:16916932}.
CC -!- DISRUPTION PHENOTYPE: Plants lacking both TIFY4A and TIFY4B have larger
CC leaves and cotyledon laminae, a dome-shaped leaf curvature and
CC shortened siliques. {ECO:0000269|PubMed:16916932}.
CC -!- MISCELLANEOUS: Redundant with TIFY 4B/PPD2.
CC -!- SIMILARITY: Belongs to the TIFY/JAZ family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB10251.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB78514.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; Z97336; CAB10251.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161539; CAB78514.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83487.1; -; Genomic_DNA.
DR EMBL; AK117854; BAC42495.1; -; mRNA.
DR PIR; A71410; A71410.
DR RefSeq; NP_193208.2; NM_117557.3.
DR AlphaFoldDB; Q8GY55; -.
DR BioGRID; 12422; 22.
DR DIP; DIP-58588N; -.
DR IntAct; Q8GY55; 13.
DR STRING; 3702.AT4G14720.1; -.
DR iPTMnet; Q8GY55; -.
DR PaxDb; Q8GY55; -.
DR PRIDE; Q8GY55; -.
DR EnsemblPlants; AT4G14720.1; AT4G14720.1; AT4G14720.
DR GeneID; 827125; -.
DR Gramene; AT4G14720.1; AT4G14720.1; AT4G14720.
DR KEGG; ath:AT4G14720; -.
DR Araport; AT4G14720; -.
DR TAIR; locus:2130155; AT4G14720.
DR eggNOG; ENOG502QWBC; Eukaryota.
DR HOGENOM; CLU_053062_0_0_1; -.
DR OMA; ARIPFQE; -.
DR PhylomeDB; Q8GY55; -.
DR PRO; PR:Q8GY55; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8GY55; baseline and differential.
DR Genevisible; Q8GY55; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0048366; P:leaf development; IMP:TAIR.
DR GO; GO:0031347; P:regulation of defense response; IBA:GO_Central.
DR GO; GO:2000022; P:regulation of jasmonic acid mediated signaling pathway; IBA:GO_Central.
DR GO; GO:1901371; P:regulation of leaf morphogenesis; IMP:TAIR.
DR GO; GO:0009611; P:response to wounding; IBA:GO_Central.
DR InterPro; IPR018467; CCT_CS.
DR InterPro; IPR040390; TIFY/JAZ.
DR InterPro; IPR010399; Tify_dom.
DR PANTHER; PTHR33077; PTHR33077; 1.
DR Pfam; PF09425; Jas_motif; 1.
DR Pfam; PF06200; tify; 1.
DR SMART; SM00979; TIFY; 1.
DR PROSITE; PS51320; TIFY; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Nucleus; Reference proteome.
FT CHAIN 1..315
FT /note="Protein TIFY 4B"
FT /id="PRO_0000300644"
FT DOMAIN 151..186
FT /note="Tify"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00650"
FT REGION 113..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 233..260
FT /note="Jas"
FT /evidence="ECO:0000255"
FT MOTIF 235..242
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 122..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 315 AA; 34849 MW; C971E8E95FA29211 CRC64;
MDVGVTTAKS ILEKPLKLLT EEDISQLTRE DCRKFLKEKG MRRPSWNKSQ AIQQVLSLKA
LYEPGDDSGA GILRKILVSQ PPNPPRVTTT LIEPRNELEA CGRIPLQEDD GACHRRDSPR
SAEFSGSSGQ FVADKDSHKT VSVSPRSPAE TNAVVGQMTI FYSGKVNVYD GVPPEKARSI
MHFAANPIDL PENGIFASSR MISKPMSKEK MVELPQYGLE KAPASRDSDV EGQANRKVSL
QRYLEKRKDR RFSKTKKAPG VASSSLEMFL NRQPRMNAAY SQNLSGTGHC ESPENQTKSP
NISVDLNSDL NSEDN
