TIFAB_HUMAN
ID TIFAB_HUMAN Reviewed; 161 AA.
AC Q6ZNK6; Q5H8A9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=TRAF-interacting protein with FHA domain-containing protein B;
DE AltName: Full=TIFA-like protein;
GN Name=TIFAB {ECO:0000303|PubMed:15047173};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:BAC85138.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen {ECO:0000312|EMBL:BAC85138.1};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAD89018.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-13, FUNCTION, AND INTERACTION WITH TIFA.
RC TISSUE=Spleen {ECO:0000312|EMBL:BAD89018.1};
RX PubMed=15047173; DOI=10.1016/j.bbrc.2004.03.030;
RA Matsumura T., Semba K., Azuma S., Ikawa S., Gohda J., Akiyama T., Inoue J.;
RT "TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated
RT domain.";
RL Biochem. Biophys. Res. Commun. 317:230-234(2004).
CC -!- FUNCTION: Inhibits TIFA-mediated TRAF6 activation possibly by inducing
CC a conformational change in TIFA. {ECO:0000269|PubMed:15047173}.
CC -!- SUBUNIT: Interacts with TIFA. {ECO:0000269|PubMed:15047173}.
CC -!- INTERACTION:
CC Q6ZNK6; Q96CG3: TIFA; NbExp=3; IntAct=EBI-26453465, EBI-740711;
CC Q6ZNK6; Q9Y4E8: USP15; NbExp=5; IntAct=EBI-26453465, EBI-1043104;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC85138.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK131088; BAC85138.1; ALT_INIT; mRNA.
DR EMBL; AB161513; BAD89018.1; -; mRNA.
DR CCDS; CCDS43365.1; -.
DR RefSeq; NP_001092691.1; NM_001099221.1.
DR AlphaFoldDB; Q6ZNK6; -.
DR SMR; Q6ZNK6; -.
DR IntAct; Q6ZNK6; 101.
DR STRING; 9606.ENSP00000440509; -.
DR BioMuta; TIFAB; -.
DR DMDM; 172046187; -.
DR MassIVE; Q6ZNK6; -.
DR PaxDb; Q6ZNK6; -.
DR PeptideAtlas; Q6ZNK6; -.
DR PRIDE; Q6ZNK6; -.
DR ProteomicsDB; 68031; -.
DR Antibodypedia; 53591; 58 antibodies from 13 providers.
DR DNASU; 497189; -.
DR Ensembl; ENST00000537858.2; ENSP00000440509.1; ENSG00000255833.2.
DR GeneID; 497189; -.
DR KEGG; hsa:497189; -.
DR MANE-Select; ENST00000537858.2; ENSP00000440509.1; NM_001099221.2; NP_001092691.1.
DR UCSC; uc003law.5; human.
DR CTD; 497189; -.
DR DisGeNET; 497189; -.
DR GeneCards; TIFAB; -.
DR HGNC; HGNC:34024; TIFAB.
DR HPA; ENSG00000255833; Tissue enhanced (lymphoid).
DR MIM; 612663; gene.
DR neXtProt; NX_Q6ZNK6; -.
DR OpenTargets; ENSG00000255833; -.
DR PharmGKB; PA162405786; -.
DR VEuPathDB; HostDB:ENSG00000255833; -.
DR eggNOG; ENOG502SPI3; Eukaryota.
DR GeneTree; ENSGT00940000154589; -.
DR HOGENOM; CLU_116346_0_0_1; -.
DR InParanoid; Q6ZNK6; -.
DR OMA; KGCVWVN; -.
DR OrthoDB; 1346020at2759; -.
DR PhylomeDB; Q6ZNK6; -.
DR TreeFam; TF333218; -.
DR PathwayCommons; Q6ZNK6; -.
DR SignaLink; Q6ZNK6; -.
DR BioGRID-ORCS; 497189; 8 hits in 1054 CRISPR screens.
DR GenomeRNAi; 497189; -.
DR Pharos; Q6ZNK6; Tbio.
DR PRO; PR:Q6ZNK6; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q6ZNK6; protein.
DR Bgee; ENSG00000255833; Expressed in vermiform appendix and 38 other tissues.
DR Genevisible; Q6ZNK6; HS.
DR GO; GO:0031223; P:auditory behavior; IGI:CAFA.
DR GO; GO:0090102; P:cochlea development; IGI:CAFA.
DR GO; GO:0090103; P:cochlea morphogenesis; IGI:CAFA.
DR GO; GO:0097094; P:craniofacial suture morphogenesis; IGI:CAFA.
DR GO; GO:0048806; P:genitalia development; IGI:CAFA.
DR GO; GO:0035112; P:genitalia morphogenesis; IGI:CAFA.
DR GO; GO:1905748; P:hard palate morphogenesis; IGI:CAFA.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR GO; GO:0048839; P:inner ear development; IGI:CAFA.
DR GO; GO:0042472; P:inner ear morphogenesis; IGI:CAFA.
DR GO; GO:0098583; P:learned vocalization behavior; IGI:CAFA.
DR GO; GO:0071626; P:mastication; IGI:CAFA.
DR GO; GO:1901078; P:negative regulation of relaxation of muscle; IGI:CAFA.
DR GO; GO:1905747; P:negative regulation of saliva secretion; IGI:CAFA.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IGI:CAFA.
DR GO; GO:0030432; P:peristalsis; IGI:CAFA.
DR GO; GO:0048634; P:regulation of muscle organ development; IGI:CAFA.
DR GO; GO:0007356; P:thorax and anterior abdomen determination; IGI:CAFA.
DR GO; GO:0021559; P:trigeminal nerve development; IGI:CAFA.
DR GO; GO:0021650; P:vestibulocochlear nerve formation; IGI:CAFA.
DR CDD; cd00060; FHA; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR033621; TIFA.
DR PANTHER; PTHR31266; PTHR31266; 1.
DR Pfam; PF00498; FHA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..161
FT /note="TRAF-interacting protein with FHA domain-containing
FT protein B"
FT /id="PRO_0000320692"
FT DOMAIN 36..91
FT /note="FHA"
FT /evidence="ECO:0000255"
SQ SEQUENCE 161 AA; 17888 MW; FE37A8C33F60BB42 CRC64;
MEKPLTVLRV SLYHPTLGPS AFANVPPRLQ HDTSPLLLGR GQDAHLQLQL PRLSRRHLSL
EPYLEKGSAL LAFCLKALSR KGCVWVNGLT LRYLEQVPLS TVNRVSFSGI QMLVRVEEGT
SLEAFVCYFH VSPSPLIYRP EAEETDEWEG ISQGQPPPGS G
